![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SCAPER |
Gene summary for SCAPER |
![]() |
Gene information | Species | Human | Gene symbol | SCAPER | Gene ID | 49855 |
Gene name | S-phase cyclin A associated protein in the ER | |
Gene Alias | IDDRP | |
Cytomap | 15q24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BY12 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
49855 | SCAPER | CCI_1 | Human | Cervix | CC | 1.87e-09 | 1.48e+00 | 0.528 |
49855 | SCAPER | CCI_3 | Human | Cervix | CC | 5.49e-13 | 1.01e+00 | 0.516 |
49855 | SCAPER | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.66e-12 | -6.18e-01 | 0.0155 |
49855 | SCAPER | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.15e-02 | -4.56e-01 | -0.1808 |
49855 | SCAPER | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.77e-07 | -6.54e-01 | -0.1207 |
49855 | SCAPER | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.65e-02 | -6.09e-01 | -0.2061 |
49855 | SCAPER | HTA11_866_3004761011 | Human | Colorectum | AD | 7.36e-10 | -5.65e-01 | 0.096 |
49855 | SCAPER | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.74e-03 | -4.50e-01 | 0.0338 |
49855 | SCAPER | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.59e-09 | -4.63e-01 | 0.0674 |
49855 | SCAPER | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.61e-03 | -3.59e-01 | 0.294 |
49855 | SCAPER | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.90e-23 | -6.86e-01 | 0.3859 |
49855 | SCAPER | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.37e-07 | -4.74e-01 | 0.3005 |
49855 | SCAPER | A015-C-203 | Human | Colorectum | FAP | 9.99e-24 | -2.62e-01 | -0.1294 |
49855 | SCAPER | A015-C-204 | Human | Colorectum | FAP | 9.84e-05 | -2.05e-01 | -0.0228 |
49855 | SCAPER | A014-C-040 | Human | Colorectum | FAP | 2.19e-03 | -3.99e-02 | -0.1184 |
49855 | SCAPER | A002-C-201 | Human | Colorectum | FAP | 1.95e-10 | -2.22e-01 | 0.0324 |
49855 | SCAPER | A001-C-119 | Human | Colorectum | FAP | 2.68e-03 | -1.32e-01 | -0.1557 |
49855 | SCAPER | A001-C-108 | Human | Colorectum | FAP | 8.33e-12 | -3.07e-02 | -0.0272 |
49855 | SCAPER | A002-C-205 | Human | Colorectum | FAP | 9.44e-20 | -2.19e-01 | -0.1236 |
49855 | SCAPER | A015-C-006 | Human | Colorectum | FAP | 5.27e-15 | -4.68e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAPER | SNV | Missense_Mutation | c.611N>T | p.Gly204Val | p.G204V | Q9BY12 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-66-2727-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCAPER | SNV | Missense_Mutation | novel | c.1508N>T | p.Trp503Leu | p.W503L | Q9BY12 | protein_coding | deleterious(0.03) | probably_damaging(0.993) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
SCAPER | SNV | Missense_Mutation | novel | c.824N>C | p.Arg275Pro | p.R275P | Q9BY12 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-98-A539-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SCAPER | SNV | Missense_Mutation | novel | c.2640N>G | p.Asn880Lys | p.N880K | Q9BY12 | protein_coding | tolerated(0.1) | benign(0.211) | TCGA-CV-7416-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SCAPER | SNV | Missense_Mutation | novel | c.508G>A | p.Ala170Thr | p.A170T | Q9BY12 | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-F7-A50J-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
SCAPER | SNV | Missense_Mutation | novel | c.2367N>T | p.Glu789Asp | p.E789D | Q9BY12 | protein_coding | tolerated(0.2) | benign(0.009) | TCGA-XK-AAJA-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
SCAPER | SNV | Missense_Mutation | c.305N>G | p.Tyr102Cys | p.Y102C | Q9BY12 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SCAPER | SNV | Missense_Mutation | rs775879520 | c.761N>T | p.Ser254Leu | p.S254L | Q9BY12 | protein_coding | tolerated(0.37) | benign(0.011) | TCGA-VQ-A8PE-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SCAPER | SNV | Missense_Mutation | novel | c.683N>A | p.Ala228Asp | p.A228D | Q9BY12 | protein_coding | deleterious(0.02) | probably_damaging(0.923) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
SCAPER | SNV | Missense_Mutation | novel | c.2282N>A | p.Ile761Asn | p.I761N | Q9BY12 | protein_coding | deleterious(0) | benign(0.336) | TCGA-VQ-AA6K-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |