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Gene: POLA1 |
Gene summary for POLA1 |
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Gene information | Species | Human | Gene symbol | POLA1 | Gene ID | 5422 |
Gene name | DNA polymerase alpha 1, catalytic subunit | |
Gene Alias | NSX | |
Cytomap | Xp22.11-p21.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A6NMQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5422 | POLA1 | CCI_1 | Human | Cervix | CC | 6.23e-09 | 7.91e-01 | 0.528 |
5422 | POLA1 | CCI_2 | Human | Cervix | CC | 8.48e-09 | 9.55e-01 | 0.5249 |
5422 | POLA1 | CCI_3 | Human | Cervix | CC | 2.72e-13 | 7.89e-01 | 0.516 |
5422 | POLA1 | AEH-subject5 | Human | Endometrium | AEH | 7.32e-03 | 2.10e-01 | -0.2953 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00324791 | Cervix | CC | regulation of type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:00326061 | Cervix | CC | type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:00718977 | Endometrium | AEH | DNA biosynthetic process | 37/2100 | 180/18723 | 1.87e-04 | 2.39e-03 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLA1 | SNV | Missense_Mutation | novel | c.3590N>A | p.Arg1197Lys | p.R1197K | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
POLA1 | SNV | Missense_Mutation | c.1787N>G | p.Lys596Arg | p.K596R | protein_coding | tolerated(0.52) | benign(0.015) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
POLA1 | SNV | Missense_Mutation | c.439T>A | p.Cys147Ser | p.C147S | protein_coding | tolerated(0.78) | benign(0) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
POLA1 | SNV | Missense_Mutation | novel | c.2140N>G | p.Leu714Val | p.L714V | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
POLA1 | SNV | Missense_Mutation | c.1252N>T | p.Asp418Tyr | p.D418Y | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | ||
POLA1 | SNV | Missense_Mutation | novel | c.1608N>T | p.Lys536Asn | p.K536N | protein_coding | tolerated(0.06) | benign(0.105) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
POLA1 | SNV | Missense_Mutation | c.2468N>A | p.Gly823Glu | p.G823E | protein_coding | tolerated(1) | possibly_damaging(0.568) | TCGA-55-8097-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
POLA1 | SNV | Missense_Mutation | novel | c.2286G>T | p.Met762Ile | p.M762I | protein_coding | deleterious(0.02) | benign(0.027) | TCGA-55-A48X-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
POLA1 | SNV | Missense_Mutation | c.2516N>C | p.Gly839Ala | p.G839A | protein_coding | tolerated(0.22) | benign(0.14) | TCGA-55-A492-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
POLA1 | SNV | Missense_Mutation | novel | c.1837G>T | p.Val613Leu | p.V613L | protein_coding | tolerated(0.62) | benign(0.001) | TCGA-73-7498-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | pemetrexed | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | BROMOVINYL DEOXYURIDINE | |||
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | FLUDARABINE | FLUDARABINE | ||
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | CLOFARABINE | CLOFARABINE | ||
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | CLOFARABINE | CLOFARABINE | ||
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | DIGALLIC ACID | DIGALLIC ACID | 1705574 | |
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | NELARABINE | NELARABINE | ||
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | FLUDARABINE | FLUDARABINE | ||
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL803 | CYTARABINE | |
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL1750 | CLOFARABINE | |
5422 | POLA1 | DNA DIRECTED RNA POLYMERASE, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL1096882 | FLUDARABINE PHOSPHATE |
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