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Gene: PLEKHG1 |
Gene summary for PLEKHG1 |
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Gene information | Species | Human | Gene symbol | PLEKHG1 | Gene ID | 57480 |
Gene name | pleckstrin homology and RhoGEF domain containing G1 | |
Gene Alias | ARHGEF41 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q5JYA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57480 | PLEKHG1 | CCI_1 | Human | Cervix | CC | 5.17e-17 | 1.32e+00 | 0.528 |
57480 | PLEKHG1 | CCI_2 | Human | Cervix | CC | 1.07e-02 | 4.15e-01 | 0.5249 |
57480 | PLEKHG1 | CCI_3 | Human | Cervix | CC | 1.19e-19 | 1.08e+00 | 0.516 |
57480 | PLEKHG1 | sample3 | Human | Cervix | CC | 1.07e-02 | 1.57e-01 | 0.1387 |
57480 | PLEKHG1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.05e-05 | -3.85e-01 | 0.0155 |
57480 | PLEKHG1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.48e-05 | 4.33e-01 | -0.1954 |
57480 | PLEKHG1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.55e-03 | -3.40e-01 | 0.0674 |
57480 | PLEKHG1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.21e-22 | -6.21e-01 | 0.294 |
57480 | PLEKHG1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.60e-09 | -4.96e-01 | 0.3859 |
57480 | PLEKHG1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.64e-11 | -5.02e-01 | 0.3005 |
57480 | PLEKHG1 | A001-C-207 | Human | Colorectum | FAP | 5.55e-07 | -4.36e-01 | 0.1278 |
57480 | PLEKHG1 | A015-C-203 | Human | Colorectum | FAP | 3.54e-32 | -6.10e-01 | -0.1294 |
57480 | PLEKHG1 | A015-C-204 | Human | Colorectum | FAP | 9.07e-06 | -2.70e-01 | -0.0228 |
57480 | PLEKHG1 | A014-C-040 | Human | Colorectum | FAP | 3.12e-03 | -3.38e-01 | -0.1184 |
57480 | PLEKHG1 | A002-C-201 | Human | Colorectum | FAP | 1.51e-13 | -3.73e-01 | 0.0324 |
57480 | PLEKHG1 | A001-C-119 | Human | Colorectum | FAP | 1.42e-08 | -5.55e-01 | -0.1557 |
57480 | PLEKHG1 | A001-C-108 | Human | Colorectum | FAP | 6.39e-21 | -5.41e-01 | -0.0272 |
57480 | PLEKHG1 | A002-C-205 | Human | Colorectum | FAP | 1.05e-21 | -4.46e-01 | -0.1236 |
57480 | PLEKHG1 | A001-C-104 | Human | Colorectum | FAP | 4.12e-13 | -4.73e-01 | 0.0184 |
57480 | PLEKHG1 | A015-C-005 | Human | Colorectum | FAP | 8.15e-05 | -3.57e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
GO:00510567 | Endometrium | AEH | regulation of small GTPase mediated signal transduction | 59/2100 | 302/18723 | 1.43e-05 | 3.03e-04 | 59 |
GO:005105612 | Endometrium | EEC | regulation of small GTPase mediated signal transduction | 61/2168 | 302/18723 | 9.42e-06 | 2.08e-04 | 61 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:00510565 | Lung | IAC | regulation of small GTPase mediated signal transduction | 70/2061 | 302/18723 | 9.44e-10 | 1.87e-07 | 70 |
GO:005105611 | Lung | AIS | regulation of small GTPase mediated signal transduction | 66/1849 | 302/18723 | 4.26e-10 | 9.53e-08 | 66 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHG1 | insertion | Frame_Shift_Ins | novel | c.2969_2970insTCATAAAG | p.Asn991HisfsTer7 | p.N991Hfs*7 | Q9ULL1 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
PLEKHG1 | insertion | Frame_Shift_Ins | novel | c.3757_3758insCGGAG | p.Arg1253ThrfsTer7 | p.R1253Tfs*7 | Q9ULL1 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
PLEKHG1 | SNV | Missense_Mutation | c.4125N>C | p.Lys1375Asn | p.K1375N | Q9ULL1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EJ-5508-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
PLEKHG1 | SNV | Missense_Mutation | c.1915N>A | p.Gly639Arg | p.G639R | Q9ULL1 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-HC-7750-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
PLEKHG1 | SNV | Missense_Mutation | rs750832410 | c.1033N>A | p.Asp345Asn | p.D345N | Q9ULL1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PLEKHG1 | SNV | Missense_Mutation | rs371565523 | c.2026C>T | p.Arg676Trp | p.R676W | Q9ULL1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEKHG1 | SNV | Missense_Mutation | c.32N>A | p.Ser11Asn | p.S11N | Q9ULL1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLEKHG1 | SNV | Missense_Mutation | c.584N>A | p.Ser195Asn | p.S195N | Q9ULL1 | protein_coding | tolerated(0.05) | probably_damaging(0.98) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLEKHG1 | SNV | Missense_Mutation | c.1214N>T | p.Arg405Leu | p.R405L | Q9ULL1 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLEKHG1 | SNV | Missense_Mutation | c.2458N>G | p.Leu820Val | p.L820V | Q9ULL1 | protein_coding | tolerated(0.39) | benign(0.058) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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