|
Gene: PCNX3 |
Gene summary for PCNX3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PCNX3 | Gene ID | 399909 |
Gene name | pecanex 3 | |
Gene Alias | PCNXL3 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6A9 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399909 | PCNX3 | HCC1 | Human | Liver | HCC | 3.31e-02 | 2.09e+00 | 0.5336 |
399909 | PCNX3 | HCC2 | Human | Liver | HCC | 4.23e-05 | 2.38e+00 | 0.5341 |
399909 | PCNX3 | S014 | Human | Liver | HCC | 1.86e-09 | 3.11e-01 | 0.2254 |
399909 | PCNX3 | S015 | Human | Liver | HCC | 3.13e-06 | 3.32e-01 | 0.2375 |
399909 | PCNX3 | S016 | Human | Liver | HCC | 2.64e-10 | 2.88e-01 | 0.2243 |
399909 | PCNX3 | S027 | Human | Liver | HCC | 1.02e-04 | 3.53e-01 | 0.2446 |
399909 | PCNX3 | S028 | Human | Liver | HCC | 1.98e-25 | 6.35e-01 | 0.2503 |
399909 | PCNX3 | S029 | Human | Liver | HCC | 2.31e-16 | 5.42e-01 | 0.2581 |
Page: 1 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCNX3 | SNV | Missense_Mutation | novel | c.4592C>T | p.Ser1531Leu | p.S1531L | Q9H6A9 | protein_coding | deleterious(0) | benign(0.238) | TCGA-D6-A6EM-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PCNX3 | SNV | Missense_Mutation | novel | c.2392N>T | p.Gly798Cys | p.G798C | Q9H6A9 | protein_coding | tolerated(0.14) | possibly_damaging(0.57) | TCGA-D6-A74Q-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.1207N>T | p.Pro403Ser | p.P403S | Q9H6A9 | protein_coding | tolerated(0.64) | possibly_damaging(0.829) | TCGA-F7-A50G-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | rs767095476 | c.4564G>A | p.Gly1522Ser | p.G1522S | Q9H6A9 | protein_coding | tolerated(0.21) | benign(0.071) | TCGA-MT-A67D-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.3113N>T | p.Pro1038Leu | p.P1038L | Q9H6A9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-UF-A71D-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | c.5296C>T | p.Arg1766Cys | p.R1766C | Q9H6A9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-UF-A7JD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCNX3 | SNV | Missense_Mutation | rs755865706 | c.1229G>A | p.Arg410Gln | p.R410Q | Q9H6A9 | protein_coding | tolerated(0.1) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PCNX3 | SNV | Missense_Mutation | rs763612581 | c.3070C>T | p.Arg1024Cys | p.R1024C | Q9H6A9 | protein_coding | deleterious(0.04) | possibly_damaging(0.898) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PCNX3 | SNV | Missense_Mutation | rs548248348 | c.3137G>A | p.Arg1046His | p.R1046H | Q9H6A9 | protein_coding | deleterious(0.01) | possibly_damaging(0.511) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PCNX3 | SNV | Missense_Mutation | novel | c.4540G>A | p.Ala1514Thr | p.A1514T | Q9H6A9 | protein_coding | tolerated(0.1) | possibly_damaging(0.746) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |