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Gene: NUP214 |
Gene summary for NUP214 |
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Gene information | Species | Human | Gene symbol | NUP214 | Gene ID | 8021 |
Gene name | nucleoporin 214 | |
Gene Alias | CAIN | |
Cytomap | 9q34.13 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | P35658 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8021 | NUP214 | CCI_2 | Human | Cervix | CC | 3.48e-11 | 1.13e+00 | 0.5249 |
8021 | NUP214 | CCI_3 | Human | Cervix | CC | 2.57e-05 | 5.81e-01 | 0.516 |
8021 | NUP214 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.84e-05 | -2.18e-02 | -0.1869 |
8021 | NUP214 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.28e-09 | -3.63e-02 | -0.1875 |
8021 | NUP214 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.31e-06 | -1.36e-02 | -0.1883 |
8021 | NUP214 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.53e-02 | 2.32e-02 | -0.1934 |
8021 | NUP214 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.95e-08 | -4.51e-02 | -0.1917 |
8021 | NUP214 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.70e-10 | -1.21e-02 | -0.1916 |
8021 | NUP214 | LZE2T | Human | Esophagus | ESCC | 8.90e-03 | 5.21e-01 | 0.082 |
8021 | NUP214 | LZE4T | Human | Esophagus | ESCC | 5.60e-15 | 2.20e-01 | 0.0811 |
8021 | NUP214 | LZE7T | Human | Esophagus | ESCC | 3.61e-07 | 4.05e-01 | 0.0667 |
8021 | NUP214 | LZE8T | Human | Esophagus | ESCC | 1.22e-03 | 1.71e-01 | 0.067 |
8021 | NUP214 | LZE20T | Human | Esophagus | ESCC | 3.44e-11 | 3.59e-01 | 0.0662 |
8021 | NUP214 | LZE21D1 | Human | Esophagus | HGIN | 2.30e-02 | 3.54e-01 | 0.0632 |
8021 | NUP214 | LZE24T | Human | Esophagus | ESCC | 1.43e-05 | 2.44e-01 | 0.0596 |
8021 | NUP214 | LZE21T | Human | Esophagus | ESCC | 3.45e-02 | 1.41e-01 | 0.0655 |
8021 | NUP214 | LZE6T | Human | Esophagus | ESCC | 1.57e-03 | 1.95e-01 | 0.0845 |
8021 | NUP214 | P2T-E | Human | Esophagus | ESCC | 6.86e-41 | 6.63e-01 | 0.1177 |
8021 | NUP214 | P4T-E | Human | Esophagus | ESCC | 6.27e-09 | 2.51e-01 | 0.1323 |
8021 | NUP214 | P5T-E | Human | Esophagus | ESCC | 2.48e-12 | 2.35e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00468229 | Cervix | CC | regulation of nucleocytoplasmic transport | 31/2311 | 106/18723 | 2.68e-06 | 7.87e-05 | 31 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00170388 | Cervix | CC | protein import | 48/2311 | 206/18723 | 8.62e-06 | 1.98e-04 | 48 |
GO:00511689 | Cervix | CC | nuclear export | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00511707 | Cervix | CC | import into nucleus | 38/2311 | 159/18723 | 3.98e-05 | 6.18e-04 | 38 |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00066067 | Cervix | CC | protein import into nucleus | 37/2311 | 155/18723 | 5.13e-05 | 7.71e-04 | 37 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00066116 | Cervix | CC | protein export from nucleus | 17/2311 | 57/18723 | 3.61e-04 | 3.75e-03 | 17 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:00714262 | Cervix | CC | ribonucleoprotein complex export from nucleus | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:00711662 | Cervix | CC | ribonucleoprotein complex localization | 18/2311 | 77/18723 | 5.15e-03 | 3.03e-02 | 18 |
GO:00064054 | Cervix | CC | RNA export from nucleus | 19/2311 | 84/18723 | 6.02e-03 | 3.43e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501419 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501425 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0501435 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa030137 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa0301312 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP214 | SNV | Missense_Mutation | rs767288782 | c.3019N>A | p.Glu1007Lys | p.E1007K | P35658 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-CG-4474-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NUP214 | SNV | Missense_Mutation | c.4864T>C | p.Ser1622Pro | p.S1622P | P35658 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NUP214 | SNV | Missense_Mutation | c.3797N>G | p.Glu1266Gly | p.E1266G | P35658 | protein_coding | tolerated(0.25) | benign(0.009) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NUP214 | SNV | Missense_Mutation | novel | c.1393N>T | p.Ala465Ser | p.A465S | P35658 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-D7-A6EX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NUP214 | SNV | Missense_Mutation | rs754369510 | c.922A>G | p.Ser308Gly | p.S308G | P35658 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUP214 | SNV | Missense_Mutation | c.2129N>G | p.Ile710Ser | p.I710S | P35658 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NUP214 | SNV | Missense_Mutation | novel | c.5855N>A | p.Gly1952Glu | p.G1952E | P35658 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NUP214 | SNV | Missense_Mutation | novel | c.3928N>A | p.Leu1310Met | p.L1310M | P35658 | protein_coding | tolerated(0.12) | possibly_damaging(0.668) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NUP214 | SNV | Missense_Mutation | rs773466988 | c.5012N>T | p.Thr1671Met | p.T1671M | P35658 | protein_coding | deleterious(0.01) | possibly_damaging(0.653) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NUP214 | SNV | Missense_Mutation | novel | c.1299N>G | p.Ser433Arg | p.S433R | P35658 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VQ-A8P8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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