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Gene: NHS |
Gene summary for NHS |
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Gene information | Species | Human | Gene symbol | NHS | Gene ID | 4810 |
Gene name | NHS actin remodeling regulator | |
Gene Alias | CTRCT40 | |
Cytomap | Xp22.2-p22.13 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q6T4R5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4810 | NHS | CCI_1 | Human | Cervix | CC | 6.42e-04 | 5.73e-01 | 0.528 |
4810 | NHS | CCI_2 | Human | Cervix | CC | 1.68e-08 | 7.46e-01 | 0.5249 |
4810 | NHS | CCI_3 | Human | Cervix | CC | 3.40e-16 | 8.11e-01 | 0.516 |
4810 | NHS | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.17e-02 | -3.99e-01 | -0.1207 |
4810 | NHS | HTA11_696_2000001011 | Human | Colorectum | AD | 6.59e-05 | -2.93e-01 | -0.1464 |
4810 | NHS | HTA11_866_2000001011 | Human | Colorectum | AD | 3.39e-02 | -2.46e-01 | -0.1001 |
4810 | NHS | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.98e-06 | -2.88e-01 | 0.3859 |
4810 | NHS | A015-C-203 | Human | Colorectum | FAP | 1.55e-08 | -2.26e-01 | -0.1294 |
4810 | NHS | A002-C-203 | Human | Colorectum | FAP | 2.38e-05 | 5.32e-01 | 0.2786 |
4810 | NHS | A001-C-108 | Human | Colorectum | FAP | 2.26e-03 | 7.67e-02 | -0.0272 |
4810 | NHS | A002-C-205 | Human | Colorectum | FAP | 1.17e-04 | -2.10e-01 | -0.1236 |
4810 | NHS | A015-C-006 | Human | Colorectum | FAP | 3.32e-02 | -3.20e-02 | -0.0994 |
4810 | NHS | A002-C-114 | Human | Colorectum | FAP | 1.15e-03 | -2.86e-01 | -0.1561 |
4810 | NHS | A015-C-104 | Human | Colorectum | FAP | 4.16e-12 | -3.13e-01 | -0.1899 |
4810 | NHS | A001-C-014 | Human | Colorectum | FAP | 3.64e-02 | 7.85e-03 | 0.0135 |
4810 | NHS | A002-C-016 | Human | Colorectum | FAP | 1.25e-07 | -4.38e-02 | 0.0521 |
4810 | NHS | A001-C-203 | Human | Colorectum | FAP | 7.89e-03 | -8.55e-03 | -0.0481 |
4810 | NHS | A002-C-116 | Human | Colorectum | FAP | 1.19e-12 | -1.35e-01 | -0.0452 |
4810 | NHS | A018-E-020 | Human | Colorectum | FAP | 8.43e-04 | -2.62e-01 | -0.2034 |
4810 | NHS | F034 | Human | Colorectum | FAP | 4.39e-04 | -5.44e-02 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
GO:0048880 | Cervix | CC | sensory system development | 63/2311 | 381/18723 | 9.29e-03 | 4.66e-02 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NHS | SNV | Missense_Mutation | c.1898N>A | p.Ser633Tyr | p.S633Y | Q6T4R5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NHS | SNV | Missense_Mutation | novel | c.2726N>T | p.Ser909Leu | p.S909L | Q6T4R5 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NHS | SNV | Missense_Mutation | novel | c.3304N>A | p.Leu1102Met | p.L1102M | Q6T4R5 | protein_coding | tolerated(0.06) | benign(0.444) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NHS | SNV | Missense_Mutation | rs745989162 | c.632N>A | p.Arg211His | p.R211H | Q6T4R5 | protein_coding | tolerated(0.21) | benign(0.011) | TCGA-EY-A1GQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
NHS | SNV | Missense_Mutation | c.2497C>T | p.Arg833Cys | p.R833C | Q6T4R5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NHS | SNV | Missense_Mutation | novel | c.3940G>A | p.Asp1314Asn | p.D1314N | Q6T4R5 | protein_coding | tolerated_low_confidence(0.14) | possibly_damaging(0.461) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NHS | SNV | Missense_Mutation | novel | c.4871G>A | p.Arg1624His | p.R1624H | Q6T4R5 | protein_coding | deleterious(0.05) | probably_damaging(0.91) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NHS | SNV | Missense_Mutation | novel | c.4352C>T | p.Ala1451Val | p.A1451V | Q6T4R5 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NHS | deletion | Frame_Shift_Del | c.761delN | p.Leu256PhefsTer28 | p.L256Ffs*28 | Q6T4R5 | protein_coding | TCGA-D1-A16F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
NHS | deletion | Frame_Shift_Del | c.761delN | p.Leu256PhefsTer28 | p.L256Ffs*28 | Q6T4R5 | protein_coding | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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