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Gene: MYO3B |
Gene summary for MYO3B |
Gene summary. |
Gene information | Species | Human | Gene symbol | MYO3B | Gene ID | 140469 |
Gene name | myosin IIIB | |
Gene Alias | MYO3B | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B7ZM71 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140469 | MYO3B | HCC1 | Human | Liver | HCC | 5.93e-05 | 4.79e-01 | 0.5336 |
140469 | MYO3B | HCC2 | Human | Liver | HCC | 2.79e-23 | 1.46e+00 | 0.5341 |
140469 | MYO3B | HCC5 | Human | Liver | HCC | 3.79e-24 | 1.17e+00 | 0.4932 |
140469 | MYO3B | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.28e-05 | 6.88e-01 | 0.343 |
140469 | MYO3B | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.02e-16 | 9.33e-01 | 0.1829 |
140469 | MYO3B | RNA-P3T-P3T-2 | Human | Lung | IAC | 4.73e-12 | 7.95e-01 | 0.1835 |
140469 | MYO3B | RNA-P3T-P3T-4 | Human | Lung | IAC | 7.47e-20 | 9.82e-01 | 0.1859 |
140469 | MYO3B | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.64e-16 | 5.44e-01 | -0.0166 |
140469 | MYO3B | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.18e-16 | 4.97e-01 | -0.0132 |
140469 | MYO3B | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 8.04e-21 | 5.82e-01 | -0.013 |
140469 | MYO3B | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 9.48e-21 | 6.37e-01 | -0.0121 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485684 | Lung | IAC | embryonic organ development | 64/2061 | 427/18723 | 6.46e-03 | 4.59e-02 | 64 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYO3B | SNV | Missense_Mutation | novel | c.47N>A | p.Gly16Glu | p.G16E | Q8WXR4 | protein_coding | tolerated(0.46) | benign(0.221) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
MYO3B | SNV | Missense_Mutation | novel | c.1770G>T | p.Arg590Ser | p.R590S | Q8WXR4 | protein_coding | deleterious(0.05) | benign(0.015) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
MYO3B | SNV | Missense_Mutation | novel | c.1040N>C | p.Asp347Ala | p.D347A | Q8WXR4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-NC-A5HL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYO3B | SNV | Missense_Mutation | novel | c.2389G>A | p.Glu797Lys | p.E797K | Q8WXR4 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MYO3B | insertion | Frame_Shift_Ins | novel | c.584dupC | p.Phe196ValfsTer6 | p.F196Vfs*6 | Q8WXR4 | protein_coding | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | ||
MYO3B | SNV | Missense_Mutation | novel | c.2719G>T | p.Gly907Trp | p.G907W | Q8WXR4 | protein_coding | deleterious(0.03) | probably_damaging(0.977) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MYO3B | SNV | Missense_Mutation | novel | c.77C>T | p.Thr26Ile | p.T26I | Q8WXR4 | protein_coding | tolerated(0.16) | possibly_damaging(0.836) | TCGA-CR-6487-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MYO3B | SNV | Missense_Mutation | novel | c.2407N>A | p.Gln803Lys | p.Q803K | Q8WXR4 | protein_coding | tolerated(0.37) | benign(0.023) | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYO3B | SNV | Missense_Mutation | novel | c.2266N>A | p.Ala756Thr | p.A756T | Q8WXR4 | protein_coding | tolerated(0.17) | benign(0.393) | TCGA-CV-6960-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
MYO3B | SNV | Missense_Mutation | novel | c.184N>T | p.Ser62Cys | p.S62C | Q8WXR4 | protein_coding | tolerated(0.18) | possibly_damaging(0.84) | TCGA-CV-7255-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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