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Gene: MYH7B |
Gene summary for MYH7B |
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Gene information | Species | Human | Gene symbol | MYH7B | Gene ID | 57644 |
Gene name | myosin heavy chain 7B | |
Gene Alias | MHC14 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A7E2Y1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57644 | MYH7B | HCC1 | Human | Liver | HCC | 9.55e-11 | 6.11e+00 | 0.5336 |
57644 | MYH7B | S014 | Human | Liver | HCC | 1.60e-31 | 3.32e+00 | 0.2254 |
57644 | MYH7B | S015 | Human | Liver | HCC | 1.19e-15 | 2.49e+00 | 0.2375 |
57644 | MYH7B | S016 | Human | Liver | HCC | 3.55e-37 | 3.15e+00 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYH7B | SNV | Missense_Mutation | novel | c.5127G>T | p.Glu1709Asp | p.E1709D | A7E2Y1 | protein_coding | tolerated(0.24) | benign(0.047) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | novel | c.5691G>T | p.Lys1897Asn | p.K1897N | A7E2Y1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | novel | c.2376G>T | p.Glu792Asp | p.E792D | A7E2Y1 | protein_coding | deleterious(0.02) | benign(0.202) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | rs572532230 | c.1084N>A | p.Val362Ile | p.V362I | A7E2Y1 | protein_coding | deleterious(0.03) | benign(0.313) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | rs374907349 | c.5558C>T | p.Ala1853Val | p.A1853V | A7E2Y1 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | rs561558848 | c.389A>G | p.Asp130Gly | p.D130G | A7E2Y1 | protein_coding | deleterious(0) | possibly_damaging(0.565) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MYH7B | SNV | Missense_Mutation | rs374369942 | c.560G>A | p.Arg187His | p.R187H | A7E2Y1 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MYH7B | SNV | Missense_Mutation | rs764714509 | c.3787C>T | p.Arg1263Trp | p.R1263W | A7E2Y1 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MYH7B | deletion | Frame_Shift_Del | novel | c.3447delN | p.Ala1151ProfsTer45 | p.A1151Pfs*45 | A7E2Y1 | protein_coding | TCGA-D1-A17K-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MYH7B | SNV | Missense_Mutation | rs747498123 | c.5519N>A | p.Arg1840His | p.R1840H | A7E2Y1 | protein_coding | deleterious(0.01) | possibly_damaging(0.482) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57644 | MYH7B | NA | activator | CHEMBL1800955 | OMECAMTIV MECARBIL |
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