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Gene: MCF2L2 |
Gene summary for MCF2L2 |
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Gene information | Species | Human | Gene symbol | MCF2L2 | Gene ID | 23101 |
Gene name | MCF.2 cell line derived transforming sequence-like 2 | |
Gene Alias | ARHGEF22 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q86YR7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23101 | MCF2L2 | CCI_1 | Human | Cervix | CC | 9.95e-07 | 4.69e-01 | 0.528 |
23101 | MCF2L2 | CCI_2 | Human | Cervix | CC | 2.15e-06 | 5.00e-01 | 0.5249 |
23101 | MCF2L2 | CCI_3 | Human | Cervix | CC | 3.98e-05 | 3.21e-01 | 0.516 |
23101 | MCF2L2 | LZE4T | Human | Esophagus | ESCC | 1.04e-04 | 2.03e-01 | 0.0811 |
23101 | MCF2L2 | LZE24T | Human | Esophagus | ESCC | 4.14e-03 | 1.61e-01 | 0.0596 |
23101 | MCF2L2 | P9T-E | Human | Esophagus | ESCC | 1.31e-05 | 1.12e-01 | 0.1131 |
23101 | MCF2L2 | P12T-E | Human | Esophagus | ESCC | 5.68e-24 | 5.20e-01 | 0.1122 |
23101 | MCF2L2 | P15T-E | Human | Esophagus | ESCC | 7.93e-03 | 1.01e-01 | 0.1149 |
23101 | MCF2L2 | P20T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.20e-02 | 0.1124 |
23101 | MCF2L2 | P21T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.86e-02 | 0.1617 |
23101 | MCF2L2 | P22T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.05e-01 | 0.1236 |
23101 | MCF2L2 | P23T-E | Human | Esophagus | ESCC | 1.06e-09 | 2.94e-01 | 0.108 |
23101 | MCF2L2 | P26T-E | Human | Esophagus | ESCC | 5.87e-84 | 1.51e+00 | 0.1276 |
23101 | MCF2L2 | P28T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.30e-01 | 0.1149 |
23101 | MCF2L2 | P30T-E | Human | Esophagus | ESCC | 2.98e-03 | 2.19e-01 | 0.137 |
23101 | MCF2L2 | P39T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.48e-01 | 0.0894 |
23101 | MCF2L2 | P40T-E | Human | Esophagus | ESCC | 1.33e-02 | 8.98e-02 | 0.109 |
23101 | MCF2L2 | P42T-E | Human | Esophagus | ESCC | 6.89e-06 | 1.08e-01 | 0.1175 |
23101 | MCF2L2 | P47T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.38e-01 | 0.1067 |
23101 | MCF2L2 | P48T-E | Human | Esophagus | ESCC | 4.17e-05 | 8.36e-02 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCF2L2 | SNV | Missense_Mutation | novel | c.3145N>C | p.Cys1049Arg | p.C1049R | Q86YR7 | protein_coding | tolerated(0.73) | benign(0) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MCF2L2 | SNV | Missense_Mutation | novel | c.2341G>C | p.Asp781His | p.D781H | Q86YR7 | protein_coding | deleterious(0.04) | benign(0.03) | TCGA-56-A4BX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | chemo | CR |
MCF2L2 | SNV | Missense_Mutation | novel | c.1595N>C | p.Arg532Pro | p.R532P | Q86YR7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD |
MCF2L2 | SNV | Missense_Mutation | c.1874N>T | p.Arg625Leu | p.R625L | Q86YR7 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
MCF2L2 | SNV | Missense_Mutation | c.1906N>G | p.Lys636Glu | p.K636E | Q86YR7 | protein_coding | tolerated(1) | benign(0.306) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MCF2L2 | SNV | Missense_Mutation | novel | c.1063N>G | p.His355Asp | p.H355D | Q86YR7 | protein_coding | deleterious(0.04) | benign(0.107) | TCGA-77-A5G6-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MCF2L2 | SNV | Missense_Mutation | novel | c.2617T>C | p.Tyr873His | p.Y873H | Q86YR7 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-85-8277-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
MCF2L2 | SNV | Missense_Mutation | novel | c.167N>A | p.Arg56Gln | p.R56Q | Q86YR7 | protein_coding | deleterious(0.04) | benign(0.241) | TCGA-90-A4EE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
MCF2L2 | SNV | Missense_Mutation | novel | c.1280N>C | p.Leu427Ser | p.L427S | Q86YR7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MCF2L2 | SNV | Missense_Mutation | novel | c.2563G>A | p.Asp855Asn | p.D855N | Q86YR7 | protein_coding | tolerated(0.06) | benign(0.202) | TCGA-CN-4740-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | erbitux | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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