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Gene: LRP4 |
Gene summary for LRP4 |
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Gene information | Species | Human | Gene symbol | LRP4 | Gene ID | 4038 |
Gene name | LDL receptor related protein 4 | |
Gene Alias | CLSS | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75096 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4038 | LRP4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.55e-07 | 5.45e-01 | 0.0155 |
4038 | LRP4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.32e-03 | 4.14e-01 | 0.096 |
4038 | LRP4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.12e-26 | 1.35e+00 | 0.0674 |
4038 | LRP4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.33e-02 | 5.97e-01 | 0.0588 |
4038 | LRP4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.12e-28 | 1.07e+00 | 0.294 |
4038 | LRP4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.30e-11 | 1.26e+00 | 0.3859 |
4038 | LRP4 | A015-C-203 | Human | Colorectum | FAP | 1.56e-09 | -3.07e-03 | -0.1294 |
4038 | LRP4 | A001-C-119 | Human | Colorectum | FAP | 8.94e-43 | 1.21e+00 | -0.1557 |
4038 | LRP4 | A001-C-108 | Human | Colorectum | FAP | 8.30e-10 | 3.79e-01 | -0.0272 |
4038 | LRP4 | A002-C-021 | Human | Colorectum | FAP | 3.50e-04 | 4.88e-01 | 0.1171 |
4038 | LRP4 | A002-C-205 | Human | Colorectum | FAP | 5.06e-09 | 2.48e-01 | -0.1236 |
4038 | LRP4 | A001-C-104 | Human | Colorectum | FAP | 6.65e-09 | 4.93e-01 | 0.0184 |
4038 | LRP4 | A015-C-006 | Human | Colorectum | FAP | 4.96e-17 | 6.73e-01 | -0.0994 |
4038 | LRP4 | A015-C-106 | Human | Colorectum | FAP | 3.92e-06 | 2.41e-01 | -0.0511 |
4038 | LRP4 | A002-C-114 | Human | Colorectum | FAP | 2.65e-04 | 1.36e-01 | -0.1561 |
4038 | LRP4 | A015-C-104 | Human | Colorectum | FAP | 3.16e-13 | 5.19e-02 | -0.1899 |
4038 | LRP4 | A001-C-014 | Human | Colorectum | FAP | 4.45e-09 | 4.29e-01 | 0.0135 |
4038 | LRP4 | A002-C-016 | Human | Colorectum | FAP | 4.89e-08 | 1.58e-01 | 0.0521 |
4038 | LRP4 | A015-C-002 | Human | Colorectum | FAP | 4.37e-03 | 1.63e-01 | -0.0763 |
4038 | LRP4 | A001-C-203 | Human | Colorectum | FAP | 1.78e-05 | 3.18e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:1905477 | Colorectum | AD | positive regulation of protein localization to membrane | 46/3918 | 106/18723 | 1.47e-07 | 6.64e-06 | 46 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0071709 | Colorectum | AD | membrane assembly | 22/3918 | 50/18723 | 2.00e-04 | 2.66e-03 | 22 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0031345 | Colorectum | AD | negative regulation of cell projection organization | 58/3918 | 186/18723 | 6.37e-04 | 6.58e-03 | 58 |
GO:0044091 | Colorectum | AD | membrane biogenesis | 22/3918 | 55/18723 | 9.88e-04 | 9.28e-03 | 22 |
GO:0050770 | Colorectum | AD | regulation of axonogenesis | 49/3918 | 154/18723 | 9.88e-04 | 9.28e-03 | 49 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0010977 | Colorectum | AD | negative regulation of neuron projection development | 43/3918 | 137/18723 | 2.60e-03 | 1.97e-02 | 43 |
GO:0016358 | Colorectum | AD | dendrite development | 69/3918 | 243/18723 | 3.32e-03 | 2.42e-02 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP4 | SNV | Missense_Mutation | c.4838N>T | p.Gly1613Val | p.G1613V | O75096 | protein_coding | deleterious(0) | benign(0.131) | TCGA-93-7347-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRP4 | SNV | Missense_Mutation | novel | c.3713N>T | p.Ala1238Val | p.A1238V | O75096 | protein_coding | tolerated(0.11) | benign(0.141) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LRP4 | SNV | Missense_Mutation | novel | c.2053N>G | p.Met685Val | p.M685V | O75096 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
LRP4 | SNV | Missense_Mutation | novel | c.371N>T | p.Arg124Leu | p.R124L | O75096 | protein_coding | tolerated(0.19) | possibly_damaging(0.719) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
LRP4 | SNV | Missense_Mutation | rs185325829 | c.4831N>A | p.Gln1611Lys | p.Q1611K | O75096 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRP4 | SNV | Missense_Mutation | c.5327N>A | p.Val1776Glu | p.V1776E | O75096 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRP4 | SNV | Missense_Mutation | rs765240067 | c.4144N>T | p.Pro1382Ser | p.P1382S | O75096 | protein_coding | tolerated(0.29) | benign(0.011) | TCGA-18-3407-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LRP4 | SNV | Missense_Mutation | rs781681900 | c.418N>A | p.Asp140Asn | p.D140N | O75096 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-21-1071-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LRP4 | SNV | Missense_Mutation | rs143207358 | c.1435N>T | p.Arg479Cys | p.R479C | O75096 | protein_coding | deleterious(0.01) | possibly_damaging(0.462) | TCGA-22-4594-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LRP4 | SNV | Missense_Mutation | novel | c.1606G>C | p.Glu536Gln | p.E536Q | O75096 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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