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Gene: LMTK2 |
Gene summary for LMTK2 |
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Gene information | Species | Human | Gene symbol | LMTK2 | Gene ID | 22853 |
Gene name | lemur tyrosine kinase 2 | |
Gene Alias | AATYK2 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q8IWU2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22853 | LMTK2 | CCI_1 | Human | Cervix | CC | 2.04e-07 | 9.88e-01 | 0.528 |
22853 | LMTK2 | CCI_2 | Human | Cervix | CC | 5.57e-10 | 8.50e-01 | 0.5249 |
22853 | LMTK2 | CCI_3 | Human | Cervix | CC | 1.78e-05 | 6.20e-01 | 0.516 |
22853 | LMTK2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.11e-04 | -3.05e-01 | 0.0155 |
22853 | LMTK2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.71e-17 | 7.33e-01 | -0.1954 |
22853 | LMTK2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.10e-05 | 5.58e-01 | 0.281 |
22853 | LMTK2 | A015-C-203 | Human | Colorectum | FAP | 4.93e-22 | -3.57e-01 | -0.1294 |
22853 | LMTK2 | A015-C-204 | Human | Colorectum | FAP | 2.57e-03 | -2.42e-01 | -0.0228 |
22853 | LMTK2 | A002-C-201 | Human | Colorectum | FAP | 7.57e-13 | -4.13e-01 | 0.0324 |
22853 | LMTK2 | A001-C-108 | Human | Colorectum | FAP | 4.32e-10 | -2.25e-01 | -0.0272 |
22853 | LMTK2 | A002-C-205 | Human | Colorectum | FAP | 9.92e-16 | -3.80e-01 | -0.1236 |
22853 | LMTK2 | A015-C-005 | Human | Colorectum | FAP | 2.77e-04 | -2.96e-01 | -0.0336 |
22853 | LMTK2 | A015-C-006 | Human | Colorectum | FAP | 1.37e-09 | -2.71e-01 | -0.0994 |
22853 | LMTK2 | A015-C-106 | Human | Colorectum | FAP | 1.96e-10 | -2.76e-01 | -0.0511 |
22853 | LMTK2 | A002-C-114 | Human | Colorectum | FAP | 3.89e-12 | -3.40e-01 | -0.1561 |
22853 | LMTK2 | A015-C-104 | Human | Colorectum | FAP | 4.20e-21 | -3.89e-01 | -0.1899 |
22853 | LMTK2 | A001-C-014 | Human | Colorectum | FAP | 4.70e-09 | -1.85e-01 | 0.0135 |
22853 | LMTK2 | A002-C-016 | Human | Colorectum | FAP | 3.31e-14 | -2.85e-01 | 0.0521 |
22853 | LMTK2 | A015-C-002 | Human | Colorectum | FAP | 3.92e-07 | -3.33e-01 | -0.0763 |
22853 | LMTK2 | A001-C-203 | Human | Colorectum | FAP | 5.68e-07 | -1.47e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00181057 | Cervix | CC | peptidyl-serine phosphorylation | 63/2311 | 315/18723 | 6.65e-05 | 9.47e-04 | 63 |
GO:00182096 | Cervix | CC | peptidyl-serine modification | 66/2311 | 338/18723 | 9.58e-05 | 1.25e-03 | 66 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00431127 | Cervix | CC | receptor metabolic process | 37/2311 | 166/18723 | 2.31e-04 | 2.58e-03 | 37 |
GO:00181076 | Cervix | CC | peptidyl-threonine phosphorylation | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:00182106 | Cervix | CC | peptidyl-threonine modification | 26/2311 | 125/18723 | 4.98e-03 | 2.97e-02 | 26 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0001881 | Colorectum | AD | receptor recycling | 18/3918 | 33/18723 | 2.23e-05 | 4.40e-04 | 18 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LMTK2 | SNV | Missense_Mutation | c.559N>A | p.Glu187Lys | p.E187K | Q8IWU2 | protein_coding | deleterious(0.01) | benign(0.403) | TCGA-HC-A6AL-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
LMTK2 | SNV | Missense_Mutation | rs757563317 | c.1769N>T | p.Thr590Met | p.T590M | Q8IWU2 | protein_coding | tolerated(0.34) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
LMTK2 | deletion | Frame_Shift_Del | novel | c.1584_1585delNN | p.Val529ProfsTer12 | p.V529Pfs*12 | Q8IWU2 | protein_coding | TCGA-ZG-A9L1-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | ||
LMTK2 | SNV | Missense_Mutation | rs61734172 | c.2528C>T | p.Thr843Met | p.T843M | Q8IWU2 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LMTK2 | SNV | Missense_Mutation | c.1664N>C | p.Leu555Ser | p.L555S | Q8IWU2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LMTK2 | SNV | Missense_Mutation | c.1538N>T | p.Ser513Leu | p.S513L | Q8IWU2 | protein_coding | tolerated(0.08) | possibly_damaging(0.575) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LMTK2 | SNV | Missense_Mutation | c.4411T>C | p.Phe1471Leu | p.F1471L | Q8IWU2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LMTK2 | SNV | Missense_Mutation | c.2461G>A | p.Glu821Lys | p.E821K | Q8IWU2 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
LMTK2 | SNV | Missense_Mutation | c.2024N>G | p.Asn675Ser | p.N675S | Q8IWU2 | protein_coding | tolerated(0.69) | benign(0) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
LMTK2 | SNV | Missense_Mutation | c.3473N>A | p.Ser1158Asn | p.S1158N | Q8IWU2 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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