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Gene: LMO7 |
Gene summary for LMO7 |
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Gene information | Species | Human | Gene symbol | LMO7 | Gene ID | 4008 |
Gene name | LIM domain 7 | |
Gene Alias | FBX20 | |
Cytomap | 13q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | F8J2B5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4008 | LMO7 | H2 | Human | Cervix | HSIL_HPV | 9.75e-27 | 7.46e-01 | 0.0632 |
4008 | LMO7 | T1 | Human | Cervix | CC | 2.29e-03 | 3.19e-01 | 0.0918 |
4008 | LMO7 | T2 | Human | Cervix | CC | 2.71e-04 | 5.18e-01 | 0.0709 |
4008 | LMO7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.66e-12 | -5.58e-01 | 0.0155 |
4008 | LMO7 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.40e-03 | 1.50e+00 | -0.2602 |
4008 | LMO7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.80e-02 | -5.00e-01 | -0.1207 |
4008 | LMO7 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.49e-05 | -3.54e-01 | -0.1001 |
4008 | LMO7 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.94e-04 | -4.47e-01 | 0.096 |
4008 | LMO7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.68e-14 | -4.50e-01 | 0.0674 |
4008 | LMO7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.02e-07 | 7.18e-01 | 0.294 |
4008 | LMO7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.03e-06 | 6.48e-01 | 0.281 |
4008 | LMO7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.80e-12 | -3.55e-01 | 0.3005 |
4008 | LMO7 | A015-C-203 | Human | Colorectum | FAP | 8.28e-22 | -1.87e-01 | -0.1294 |
4008 | LMO7 | A002-C-201 | Human | Colorectum | FAP | 4.44e-06 | -1.90e-01 | 0.0324 |
4008 | LMO7 | A001-C-119 | Human | Colorectum | FAP | 2.65e-02 | 8.13e-02 | -0.1557 |
4008 | LMO7 | A001-C-108 | Human | Colorectum | FAP | 1.82e-10 | 1.20e-01 | -0.0272 |
4008 | LMO7 | A002-C-205 | Human | Colorectum | FAP | 2.70e-14 | 2.74e-02 | -0.1236 |
4008 | LMO7 | A001-C-104 | Human | Colorectum | FAP | 8.45e-03 | 2.10e-01 | 0.0184 |
4008 | LMO7 | A015-C-006 | Human | Colorectum | FAP | 1.65e-09 | -5.33e-02 | -0.0994 |
4008 | LMO7 | A015-C-106 | Human | Colorectum | FAP | 1.02e-06 | 2.49e-02 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0452014 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452015 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452022 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452032 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452042 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LMO7 | SNV | Missense_Mutation | novel | c.3146N>T | p.Ser1049Leu | p.S1049L | protein_coding | tolerated(0.24) | benign(0.046) | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | |
LMO7 | SNV | Missense_Mutation | c.2579N>G | p.Val860Gly | p.V860G | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-95-8039-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
LMO7 | SNV | Missense_Mutation | rs774848818 | c.4369N>A | p.Glu1457Lys | p.E1457K | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-J2-8192-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
LMO7 | SNV | Missense_Mutation | c.137N>T | p.Cys46Phe | p.C46F | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
LMO7 | SNV | Missense_Mutation | novel | c.4268N>T | p.Arg1423Met | p.R1423M | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | rs751118448 | c.182N>G | p.Asn61Ser | p.N61S | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.4805N>A | p.Ser1602Tyr | p.S1602Y | protein_coding | deleterious(0.04) | probably_damaging(0.968) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | c.3019N>G | p.Ile1007Val | p.I1007V | protein_coding | tolerated(1) | benign(0.01) | TCGA-22-4599-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LMO7 | SNV | Missense_Mutation | novel | c.853N>A | p.Glu285Lys | p.E285K | protein_coding | deleterious(0.01) | benign(0.097) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | c.4416N>T | p.Gln1472His | p.Q1472H | protein_coding | tolerated(0.39) | benign(0.023) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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