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Gene: KIAA0586 |
Gene summary for KIAA0586 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIAA0586 | Gene ID | 9786 |
Gene name | KIAA0586 | |
Gene Alias | JBTS23 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9BVV6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9786 | KIAA0586 | LZE4T | Human | Esophagus | ESCC | 4.91e-11 | 2.57e-01 | 0.0811 |
9786 | KIAA0586 | LZE5T | Human | Esophagus | ESCC | 8.31e-04 | 2.48e-01 | 0.0514 |
9786 | KIAA0586 | LZE21D1 | Human | Esophagus | HGIN | 2.96e-02 | 2.24e-01 | 0.0632 |
9786 | KIAA0586 | LZE24T | Human | Esophagus | ESCC | 1.33e-04 | 1.46e-01 | 0.0596 |
9786 | KIAA0586 | P1T-E | Human | Esophagus | ESCC | 3.86e-02 | 1.81e-01 | 0.0875 |
9786 | KIAA0586 | P2T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.80e-01 | 0.1177 |
9786 | KIAA0586 | P4T-E | Human | Esophagus | ESCC | 1.41e-04 | 2.12e-01 | 0.1323 |
9786 | KIAA0586 | P5T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.30e-02 | 0.1327 |
9786 | KIAA0586 | P8T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.49e-01 | 0.0889 |
9786 | KIAA0586 | P9T-E | Human | Esophagus | ESCC | 3.50e-03 | 8.31e-02 | 0.1131 |
9786 | KIAA0586 | P10T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.92e-01 | 0.116 |
9786 | KIAA0586 | P12T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.52e-01 | 0.1122 |
9786 | KIAA0586 | P15T-E | Human | Esophagus | ESCC | 1.33e-12 | 3.37e-01 | 0.1149 |
9786 | KIAA0586 | P16T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.22e-01 | 0.1153 |
9786 | KIAA0586 | P17T-E | Human | Esophagus | ESCC | 1.83e-02 | 1.70e-01 | 0.1278 |
9786 | KIAA0586 | P19T-E | Human | Esophagus | ESCC | 2.12e-03 | 2.46e-01 | 0.1662 |
9786 | KIAA0586 | P20T-E | Human | Esophagus | ESCC | 1.97e-02 | 1.17e-01 | 0.1124 |
9786 | KIAA0586 | P21T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.27e-01 | 0.1617 |
9786 | KIAA0586 | P23T-E | Human | Esophagus | ESCC | 4.80e-10 | 1.60e-01 | 0.108 |
9786 | KIAA0586 | P24T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.72e-01 | 0.1287 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0586 | SNV | Missense_Mutation | rs748083468 | c.4894G>T | p.Gly1632Trp | p.G1632W | Q9BVV6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.957) | TCGA-BA-A6DG-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
KIAA0586 | SNV | Missense_Mutation | novel | c.1148N>A | p.Ser383Asn | p.S383N | Q9BVV6 | protein_coding | tolerated(0.3) | benign(0.014) | TCGA-CN-4727-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
KIAA0586 | SNV | Missense_Mutation | novel | c.2183N>T | p.Arg728Ile | p.R728I | Q9BVV6 | protein_coding | deleterious(0.01) | benign(0.366) | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
KIAA0586 | SNV | Missense_Mutation | novel | c.4374N>T | p.Leu1458Phe | p.L1458F | Q9BVV6 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
KIAA0586 | SNV | Missense_Mutation | rs563531719 | c.1127N>C | p.Leu376Ser | p.L376S | Q9BVV6 | protein_coding | tolerated(0.58) | benign(0.011) | TCGA-CV-7243-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
KIAA0586 | SNV | Missense_Mutation | c.1169N>T | p.Pro390Leu | p.P390L | Q9BVV6 | protein_coding | deleterious(0) | benign(0.187) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA0586 | SNV | Missense_Mutation | novel | c.3002T>C | p.Met1001Thr | p.M1001T | Q9BVV6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIAA0586 | insertion | In_Frame_Ins | novel | c.1266_1267insTTTTTAAAA | p.Asn422_Met423insPheLeuLys | p.N422_M423insFLK | Q9BVV6 | protein_coding | TCGA-F7-8298-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0586 | SNV | Missense_Mutation | c.1226A>G | p.Glu409Gly | p.E409G | Q9BVV6 | protein_coding | tolerated(0.15) | benign(0.006) | TCGA-HC-A6AO-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
KIAA0586 | SNV | Missense_Mutation | novel | c.20N>A | p.Cys7Tyr | p.C7Y | Q9BVV6 | protein_coding | tolerated_low_confidence(0.37) | benign(0.021) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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