![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KIAA0368 |
Gene summary for KIAA0368 |
![]() |
Gene information | Species | Human | Gene symbol | KIAA0368 | Gene ID | 23392 |
Gene name | Ecm29 proteasome adaptor and scaffold | |
Gene Alias | ECM29 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | NA |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23392 | KIAA0368 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.12e-43 | 7.58e-01 | 0.294 |
23392 | KIAA0368 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.11e-13 | 1.58e+00 | 0.3487 |
23392 | KIAA0368 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.99e-33 | 8.59e-01 | 0.281 |
23392 | KIAA0368 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.49e-45 | 7.91e-01 | 0.3859 |
23392 | KIAA0368 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.57e-07 | 3.35e-01 | 0.2585 |
23392 | KIAA0368 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.63e-19 | 3.75e-01 | 0.3005 |
23392 | KIAA0368 | P1T-E | Human | Esophagus | ESCC | 7.20e-08 | 4.51e-01 | 0.0875 |
23392 | KIAA0368 | P2T-E | Human | Esophagus | ESCC | 3.16e-29 | 5.26e-01 | 0.1177 |
23392 | KIAA0368 | P4T-E | Human | Esophagus | ESCC | 1.46e-07 | 1.30e-01 | 0.1323 |
23392 | KIAA0368 | P5T-E | Human | Esophagus | ESCC | 9.20e-21 | 3.54e-01 | 0.1327 |
23392 | KIAA0368 | P8T-E | Human | Esophagus | ESCC | 7.74e-14 | 1.66e-01 | 0.0889 |
23392 | KIAA0368 | P9T-E | Human | Esophagus | ESCC | 1.01e-08 | 2.07e-01 | 0.1131 |
23392 | KIAA0368 | P10T-E | Human | Esophagus | ESCC | 2.43e-15 | 2.04e-01 | 0.116 |
23392 | KIAA0368 | P11T-E | Human | Esophagus | ESCC | 6.82e-04 | 3.29e-01 | 0.1426 |
23392 | KIAA0368 | P12T-E | Human | Esophagus | ESCC | 3.11e-14 | 2.03e-01 | 0.1122 |
23392 | KIAA0368 | P15T-E | Human | Esophagus | ESCC | 4.38e-13 | 2.99e-01 | 0.1149 |
23392 | KIAA0368 | P16T-E | Human | Esophagus | ESCC | 2.52e-12 | 9.17e-02 | 0.1153 |
23392 | KIAA0368 | P17T-E | Human | Esophagus | ESCC | 2.28e-07 | 4.24e-01 | 0.1278 |
23392 | KIAA0368 | P19T-E | Human | Esophagus | ESCC | 3.64e-02 | 3.70e-01 | 0.1662 |
23392 | KIAA0368 | P20T-E | Human | Esophagus | ESCC | 1.14e-11 | 8.94e-02 | 0.1124 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0368 | SNV | Missense_Mutation | c.190C>T | p.Arg64Trp | p.R64W | protein_coding | deleterious_low_confidence(0) | benign(0.312) | TCGA-66-2800-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
KIAA0368 | SNV | Missense_Mutation | novel | c.5075G>T | p.Gly1692Val | p.G1692V | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-85-8580-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.5074G>T | p.Gly1692Cys | p.G1692C | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-85-8580-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.2253N>A | p.Met751Ile | p.M751I | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0368 | insertion | In_Frame_Ins | novel | c.1122_1123insAATTATGTTTTATAC | p.Gln374_Gly375insAsnTyrValLeuTyr | p.Q374_G375insNYVLY | protein_coding | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
KIAA0368 | insertion | Frame_Shift_Ins | novel | c.5648-1_5648insACCCAAC | p.Arg1883HisfsTer15 | p.R1883Hfs*15 | protein_coding | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
KIAA0368 | SNV | Missense_Mutation | novel | c.3664C>A | p.Gln1222Lys | p.Q1222K | protein_coding | deleterious(0.01) | benign(0.02) | TCGA-CV-6951-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.2820N>C | p.Lys940Asn | p.K940N | protein_coding | deleterious(0.01) | benign(0.042) | TCGA-CV-7430-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
KIAA0368 | SNV | Missense_Mutation | novel | c.5066N>T | p.Ser1689Phe | p.S1689F | protein_coding | deleterious(0) | benign(0.026) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIAA0368 | SNV | Missense_Mutation | rs745639002 | c.1801C>T | p.Arg601Trp | p.R601W | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-D6-6826-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |