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Gene: ENAM |
Gene summary for ENAM |
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Gene information | Species | Human | Gene symbol | ENAM | Gene ID | 10117 |
Gene name | enamelin | |
Gene Alias | ADAI | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0002065 | UniProtAcc | Q9NRM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10117 | ENAM | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 3.71e-02 | 5.24e-01 | 0.159 |
10117 | ENAM | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 2.46e-15 | 1.45e+00 | 0.1479 |
10117 | ENAM | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 3.78e-07 | 9.10e-01 | 0.1531 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENAM | SNV | Missense_Mutation | rs868759180 | c.2902N>A | p.Glu968Lys | p.E968K | Q9NRM1 | protein_coding | tolerated(0.17) | benign(0.096) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ENAM | SNV | Missense_Mutation | novel | c.2675A>G | p.Tyr892Cys | p.Y892C | Q9NRM1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-90-A59Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ENAM | SNV | Missense_Mutation | novel | c.1029N>A | p.His343Gln | p.H343Q | Q9NRM1 | protein_coding | tolerated(0.4) | benign(0.125) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ENAM | SNV | Missense_Mutation | novel | c.1474N>A | p.Glu492Lys | p.E492K | Q9NRM1 | protein_coding | deleterious(0.02) | possibly_damaging(0.584) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ENAM | SNV | Missense_Mutation | rs769115693 | c.2254N>A | p.Ala752Thr | p.A752T | Q9NRM1 | protein_coding | tolerated(0.06) | benign(0.102) | TCGA-CV-7414-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ENAM | SNV | Missense_Mutation | novel | c.2299G>A | p.Asp767Asn | p.D767N | Q9NRM1 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-CV-7446-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ENAM | SNV | Missense_Mutation | rs774216441 | c.838N>T | p.Gly280Trp | p.G280W | Q9NRM1 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ENAM | SNV | Missense_Mutation | novel | c.3037N>A | p.Asp1013Asn | p.D1013N | Q9NRM1 | protein_coding | tolerated(0.55) | benign(0.347) | TCGA-HD-8634-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENAM | SNV | Missense_Mutation | novel | c.1930N>A | p.Asp644Asn | p.D644N | Q9NRM1 | protein_coding | tolerated(0.06) | benign(0.149) | TCGA-HD-A633-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ENAM | deletion | In_Frame_Del | novel | c.1243_1266delNNNNNNNNNNNNNNNNNNNNNNNN | p.Thr415_Pro422del | p.T415_P422del | Q9NRM1 | protein_coding | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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