![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CSPP1 |
Gene summary for CSPP1 |
![]() |
Gene information | Species | Human | Gene symbol | CSPP1 | Gene ID | 79848 |
Gene name | centrosome and spindle pole associated protein 1 | |
Gene Alias | CSPP | |
Cytomap | 8q13.1-q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q1MSJ5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79848 | CSPP1 | CCI_2 | Human | Cervix | CC | 5.75e-20 | 1.46e+00 | 0.5249 |
79848 | CSPP1 | CCI_3 | Human | Cervix | CC | 7.53e-04 | 6.51e-01 | 0.516 |
79848 | CSPP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.39e-14 | -4.97e-01 | 0.0155 |
79848 | CSPP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.47e-04 | -4.30e-01 | -0.1808 |
79848 | CSPP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.14e-02 | -3.26e-01 | -0.0811 |
79848 | CSPP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.30e-02 | -4.55e-01 | -0.1526 |
79848 | CSPP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.64e-09 | -3.91e-01 | -0.1464 |
79848 | CSPP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.65e-05 | -3.26e-01 | -0.1001 |
79848 | CSPP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.85e-02 | -4.46e-01 | -0.0842 |
79848 | CSPP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.73e-07 | -3.90e-01 | 0.096 |
79848 | CSPP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.20e-11 | -4.39e-01 | 0.0674 |
79848 | CSPP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.32e-08 | -4.09e-01 | 0.294 |
79848 | CSPP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.05e-06 | -4.09e-01 | 0.3005 |
79848 | CSPP1 | A001-C-207 | Human | Colorectum | FAP | 1.32e-02 | -2.62e-01 | 0.1278 |
79848 | CSPP1 | A015-C-203 | Human | Colorectum | FAP | 1.74e-14 | -2.66e-01 | -0.1294 |
79848 | CSPP1 | A015-C-204 | Human | Colorectum | FAP | 3.33e-03 | -1.60e-01 | -0.0228 |
79848 | CSPP1 | A014-C-040 | Human | Colorectum | FAP | 1.44e-03 | -4.07e-01 | -0.1184 |
79848 | CSPP1 | A002-C-201 | Human | Colorectum | FAP | 5.22e-08 | -1.99e-01 | 0.0324 |
79848 | CSPP1 | A001-C-119 | Human | Colorectum | FAP | 5.57e-03 | -1.41e-01 | -0.1557 |
79848 | CSPP1 | A001-C-108 | Human | Colorectum | FAP | 6.09e-08 | -5.18e-02 | -0.0272 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00900685 | Cervix | CC | positive regulation of cell cycle process | 50/2311 | 236/18723 | 8.25e-05 | 1.11e-03 | 50 |
GO:00513021 | Cervix | CC | regulation of cell division | 39/2311 | 177/18723 | 2.05e-04 | 2.33e-03 | 39 |
GO:00009107 | Cervix | CC | cytokinesis | 37/2311 | 173/18723 | 5.40e-04 | 5.23e-03 | 37 |
GO:0032465 | Cervix | CC | regulation of cytokinesis | 22/2311 | 92/18723 | 1.55e-03 | 1.20e-02 | 22 |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:00009101 | Colorectum | SER | cytokinesis | 45/2897 | 173/18723 | 2.28e-04 | 3.93e-03 | 45 |
GO:00009102 | Colorectum | MSS | cytokinesis | 49/3467 | 173/18723 | 1.02e-03 | 1.02e-02 | 49 |
GO:00457871 | Colorectum | MSS | positive regulation of cell cycle | 80/3467 | 313/18723 | 1.15e-03 | 1.12e-02 | 80 |
GO:0090068 | Colorectum | MSS | positive regulation of cell cycle process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00457872 | Colorectum | FAP | positive regulation of cell cycle | 66/2622 | 313/18723 | 3.66e-04 | 4.63e-03 | 66 |
GO:00900681 | Colorectum | FAP | positive regulation of cell cycle process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
GO:00009103 | Colorectum | FAP | cytokinesis | 37/2622 | 173/18723 | 5.10e-03 | 3.37e-02 | 37 |
GO:00457873 | Colorectum | CRC | positive regulation of cell cycle | 55/2078 | 313/18723 | 3.76e-04 | 5.57e-03 | 55 |
GO:00009104 | Colorectum | CRC | cytokinesis | 34/2078 | 173/18723 | 6.47e-04 | 8.55e-03 | 34 |
GO:00900682 | Colorectum | CRC | positive regulation of cell cycle process | 39/2078 | 236/18723 | 7.23e-03 | 4.98e-02 | 39 |
GO:00009108 | Endometrium | AEH | cytokinesis | 40/2100 | 173/18723 | 6.01e-06 | 1.49e-04 | 40 |
GO:00457877 | Endometrium | AEH | positive regulation of cell cycle | 56/2100 | 313/18723 | 2.73e-04 | 3.14e-03 | 56 |
GO:00900686 | Endometrium | AEH | positive regulation of cell cycle process | 41/2100 | 236/18723 | 2.94e-03 | 2.09e-02 | 41 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSPP1 | SNV | Missense_Mutation | rs773480768 | c.1585N>A | p.Asp529Asn | p.D529N | Q1MSJ5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
CSPP1 | SNV | Missense_Mutation | rs771943937 | c.784G>A | p.Ala262Thr | p.A262T | Q1MSJ5 | protein_coding | tolerated(0.65) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CSPP1 | SNV | Missense_Mutation | rs778723931 | c.3244N>A | p.Val1082Ile | p.V1082I | Q1MSJ5 | protein_coding | tolerated(0.31) | benign(0) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CSPP1 | SNV | Missense_Mutation | novel | c.429N>T | p.Glu143Asp | p.E143D | Q1MSJ5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
CSPP1 | SNV | Missense_Mutation | rs374214705 | c.1456N>A | p.Ala486Thr | p.A486T | Q1MSJ5 | protein_coding | tolerated(1) | benign(0) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CSPP1 | SNV | Missense_Mutation | c.3195T>G | p.Ser1065Arg | p.S1065R | Q1MSJ5 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
CSPP1 | SNV | Missense_Mutation | novel | c.259N>A | p.Ala87Thr | p.A87T | Q1MSJ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.852) | TCGA-R5-A7ZR-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CSPP1 | SNV | Missense_Mutation | novel | c.2482N>T | p.His828Tyr | p.H828Y | Q1MSJ5 | protein_coding | tolerated(0.22) | possibly_damaging(0.851) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
CSPP1 | SNV | Missense_Mutation | novel | c.3094N>T | p.Val1032Phe | p.V1032F | Q1MSJ5 | protein_coding | tolerated(0.33) | possibly_damaging(0.904) | TCGA-BJ-A191-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CSPP1 | SNV | Missense_Mutation | rs201417325 | c.1660C>A | p.His554Asn | p.H554N | Q1MSJ5 | protein_coding | tolerated(0.35) | benign(0.108) | TCGA-EL-A3CZ-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |