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Gene: CLASP1 |
Gene summary for CLASP1 |
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Gene information | Species | Human | Gene symbol | CLASP1 | Gene ID | 23332 |
Gene name | cytoplasmic linker associated protein 1 | |
Gene Alias | MAST1 | |
Cytomap | 2q14.2-q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q7Z460 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23332 | CLASP1 | CCI_1 | Human | Cervix | CC | 3.12e-22 | 1.32e+00 | 0.528 |
23332 | CLASP1 | CCI_2 | Human | Cervix | CC | 9.62e-13 | 1.06e+00 | 0.5249 |
23332 | CLASP1 | CCI_3 | Human | Cervix | CC | 7.16e-33 | 1.55e+00 | 0.516 |
23332 | CLASP1 | AEH-subject1 | Human | Endometrium | AEH | 8.72e-16 | 4.48e-01 | -0.3059 |
23332 | CLASP1 | AEH-subject2 | Human | Endometrium | AEH | 2.66e-05 | 3.26e-01 | -0.2525 |
23332 | CLASP1 | AEH-subject3 | Human | Endometrium | AEH | 2.85e-05 | 2.89e-01 | -0.2576 |
23332 | CLASP1 | AEH-subject4 | Human | Endometrium | AEH | 7.79e-12 | 5.26e-01 | -0.2657 |
23332 | CLASP1 | AEH-subject5 | Human | Endometrium | AEH | 2.78e-09 | 4.21e-01 | -0.2953 |
23332 | CLASP1 | EEC-subject1 | Human | Endometrium | EEC | 2.06e-08 | 4.22e-01 | -0.2682 |
23332 | CLASP1 | EEC-subject2 | Human | Endometrium | EEC | 3.84e-09 | 3.98e-01 | -0.2607 |
23332 | CLASP1 | EEC-subject4 | Human | Endometrium | EEC | 5.47e-04 | 3.20e-01 | -0.2571 |
23332 | CLASP1 | EEC-subject5 | Human | Endometrium | EEC | 9.71e-11 | 4.36e-01 | -0.249 |
23332 | CLASP1 | GSM5276934 | Human | Endometrium | EEC | 1.88e-05 | -1.19e-01 | -0.0913 |
23332 | CLASP1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.56e-03 | 6.02e-04 | -0.1869 |
23332 | CLASP1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 6.19e-04 | -8.13e-02 | -0.1875 |
23332 | CLASP1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.28e-06 | -1.70e-02 | -0.1883 |
23332 | CLASP1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.04e-05 | -7.49e-03 | -0.1934 |
23332 | CLASP1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.33e-12 | -4.99e-03 | -0.1917 |
23332 | CLASP1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.83e-11 | -3.04e-02 | -0.1916 |
23332 | CLASP1 | LZE4T | Human | Esophagus | ESCC | 6.58e-19 | 5.32e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:01501159 | Cervix | CC | cell-substrate junction organization | 37/2311 | 101/18723 | 3.20e-10 | 4.46e-08 | 37 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:00070448 | Cervix | CC | cell-substrate junction assembly | 34/2311 | 95/18723 | 3.35e-09 | 3.45e-07 | 34 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLASP1 | SNV | Missense_Mutation | c.291N>G | p.Ile97Met | p.I97M | Q7Z460 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CLASP1 | SNV | Missense_Mutation | c.1375N>A | p.Ala459Thr | p.A459T | Q7Z460 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLASP1 | SNV | Missense_Mutation | rs374760188 | c.1345N>G | p.Ile449Val | p.I449V | Q7Z460 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLASP1 | SNV | Missense_Mutation | c.3107G>A | p.Ser1036Asn | p.S1036N | Q7Z460 | protein_coding | deleterious(0) | possibly_damaging(0.543) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLASP1 | SNV | Missense_Mutation | c.359A>G | p.Asp120Gly | p.D120G | Q7Z460 | protein_coding | deleterious(0.01) | benign(0.125) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLASP1 | SNV | Missense_Mutation | c.3794N>G | p.Asn1265Ser | p.N1265S | Q7Z460 | protein_coding | tolerated(0.09) | benign(0) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
CLASP1 | SNV | Missense_Mutation | c.2477N>G | p.Asp826Gly | p.D826G | Q7Z460 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | |
CLASP1 | SNV | Missense_Mutation | c.2854N>T | p.Leu952Phe | p.L952F | Q7Z460 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
CLASP1 | SNV | Missense_Mutation | novel | c.610N>A | p.Ala204Thr | p.A204T | Q7Z460 | protein_coding | tolerated(0.3) | benign(0.021) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
CLASP1 | SNV | Missense_Mutation | novel | c.2452N>T | p.Pro818Ser | p.P818S | Q7Z460 | protein_coding | tolerated(1) | benign(0.006) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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