![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ATP1A2 |
Gene summary for ATP1A2 |
![]() |
Gene information | Species | Human | Gene symbol | ATP1A2 | Gene ID | 477 |
Gene name | ATPase Na+/K+ transporting subunit alpha 2 | |
Gene Alias | FHM2 | |
Cytomap | 1q23.2 | |
Gene Type | protein-coding | GO ID | GO:0001504 | UniProtAcc | A0A0S2Z3W6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
477 | ATP1A2 | HCC1 | Human | Liver | HCC | 3.57e-07 | 2.68e+00 | 0.5336 |
477 | ATP1A2 | HCC2 | Human | Liver | HCC | 4.91e-15 | 1.23e+00 | 0.5341 |
477 | ATP1A2 | HCC5 | Human | Liver | HCC | 1.24e-04 | 7.57e-01 | 0.4932 |
477 | ATP1A2 | S014 | Human | Liver | HCC | 2.73e-09 | 5.21e-01 | 0.2254 |
477 | ATP1A2 | S015 | Human | Liver | HCC | 1.80e-10 | 8.67e-01 | 0.2375 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:004854522 | Liver | HCC | response to steroid hormone | 206/7958 | 339/18723 | 6.81e-12 | 2.92e-10 | 206 |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:007138322 | Liver | HCC | cellular response to steroid hormone stimulus | 128/7958 | 204/18723 | 3.92e-09 | 1.04e-07 | 128 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:005123521 | Liver | HCC | maintenance of location | 185/7958 | 327/18723 | 1.70e-07 | 3.12e-06 | 185 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:005165112 | Liver | HCC | maintenance of location in cell | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:19026007 | Liver | HCC | proton transmembrane transport | 87/7958 | 157/18723 | 7.27e-04 | 4.42e-03 | 87 |
GO:00712601 | Liver | HCC | cellular response to mechanical stimulus | 48/7958 | 81/18723 | 1.72e-03 | 8.96e-03 | 48 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:015010411 | Liver | HCC | transport across blood-brain barrier | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:001023211 | Liver | HCC | vascular transport | 50/7958 | 88/18723 | 4.69e-03 | 2.02e-02 | 50 |
GO:00551191 | Liver | HCC | relaxation of cardiac muscle | 13/7958 | 17/18723 | 4.77e-03 | 2.02e-02 | 13 |
GO:00860642 | Liver | HCC | cell communication by electrical coupling involved in cardiac conduction | 17/7958 | 25/18723 | 8.94e-03 | 3.45e-02 | 17 |
GO:0010882 | Liver | HCC | regulation of cardiac muscle contraction by calcium ion signaling | 18/7958 | 27/18723 | 9.75e-03 | 3.66e-02 | 18 |
GO:0010881 | Liver | HCC | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 15/7958 | 22/18723 | 1.35e-02 | 4.80e-02 | 15 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP1A2 | SNV | Missense_Mutation | novel | c.1178A>T | p.Asn393Ile | p.N393I | P50993 | protein_coding | deleterious(0.01) | possibly_damaging(0.789) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP1A2 | SNV | Missense_Mutation | novel | c.953N>T | p.Ala318Val | p.A318V | P50993 | protein_coding | deleterious(0.04) | possibly_damaging(0.722) | TCGA-UF-A71D-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP1A2 | SNV | Missense_Mutation | rs751210232 | c.1051N>T | p.Arg351Trp | p.R351W | P50993 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP1A2 | SNV | Missense_Mutation | c.1519N>A | p.Ala507Thr | p.A507T | P50993 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP1A2 | SNV | Missense_Mutation | c.998N>A | p.Gly333Glu | p.G333E | P50993 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ATP1A2 | SNV | Missense_Mutation | c.1133C>T | p.Thr378Ile | p.T378I | P50993 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
ATP1A2 | SNV | Missense_Mutation | rs761597771 | c.2636N>A | p.Arg879Gln | p.R879Q | P50993 | protein_coding | tolerated(0.68) | benign(0.006) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ATP1A2 | SNV | Missense_Mutation | c.799N>T | p.Arg267Cys | p.R267C | P50993 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4441-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATP1A2 | SNV | Missense_Mutation | rs747283283 | c.151C>T | p.Arg51Cys | p.R51C | P50993 | protein_coding | deleterious(0.02) | benign(0.094) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP1A2 | SNV | Missense_Mutation | rs781474239 | c.1540N>T | p.Arg514Trp | p.R514W | P50993 | protein_coding | deleterious(0.01) | probably_damaging(0.926) | TCGA-D7-6815-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | olanzapine | OLANZAPINE | ||
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL3545057 | ACETYLDIGITOXIN | |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL254219 | DIGITOXIN | |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL1751 | DIGOXIN | |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL1614 | DESLANOSIDE |
Page: 1 |