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Gene: ADAMTS2 |
Gene summary for ADAMTS2 |
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Gene information | Species | Human | Gene symbol | ADAMTS2 | Gene ID | 9509 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 2 | |
Gene Alias | ADAM-TS2 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O95450 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9509 | ADAMTS2 | ATC12 | Human | Thyroid | ATC | 1.72e-28 | 6.12e-01 | 0.34 |
9509 | ADAMTS2 | ATC13 | Human | Thyroid | ATC | 3.04e-38 | 6.43e-01 | 0.34 |
9509 | ADAMTS2 | ATC2 | Human | Thyroid | ATC | 2.49e-06 | 6.31e-01 | 0.34 |
9509 | ADAMTS2 | ATC4 | Human | Thyroid | ATC | 1.32e-34 | 7.35e-01 | 0.34 |
9509 | ADAMTS2 | ATC5 | Human | Thyroid | ATC | 8.04e-38 | 7.08e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:003019911 | Thyroid | ATC | collagen fibril organization | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
GO:003032321 | Thyroid | ATC | respiratory tube development | 93/6293 | 181/18723 | 5.67e-07 | 8.02e-06 | 93 |
GO:003032421 | Thyroid | ATC | lung development | 90/6293 | 177/18723 | 1.53e-06 | 1.88e-05 | 90 |
GO:006054121 | Thyroid | ATC | respiratory system development | 100/6293 | 203/18723 | 2.66e-06 | 3.08e-05 | 100 |
GO:0051604110 | Thyroid | ATC | protein maturation | 136/6293 | 294/18723 | 4.00e-06 | 4.42e-05 | 136 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
GO:001648515 | Thyroid | ATC | protein processing | 100/6293 | 225/18723 | 4.39e-04 | 2.62e-03 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS2 | SNV | Missense_Mutation | c.2858N>T | p.Ser953Phe | p.S953F | O95450 | protein_coding | deleterious(0.01) | possibly_damaging(0.762) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ADAMTS2 | SNV | Missense_Mutation | novel | c.1442T>C | p.Leu481Pro | p.L481P | O95450 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ADAMTS2 | SNV | Missense_Mutation | c.1061C>A | p.Thr354Lys | p.T354K | O95450 | protein_coding | deleterious(0.04) | possibly_damaging(0.822) | TCGA-97-A4M3-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ADAMTS2 | SNV | Missense_Mutation | c.1279N>A | p.Asp427Asn | p.D427N | O95450 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-J2-8194-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
ADAMTS2 | SNV | Missense_Mutation | c.2412G>T | p.Glu804Asp | p.E804D | O95450 | protein_coding | tolerated(0.06) | possibly_damaging(0.772) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ADAMTS2 | SNV | Missense_Mutation | c.2290G>T | p.Ala764Ser | p.A764S | O95450 | protein_coding | tolerated(0.06) | benign(0.104) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ADAMTS2 | SNV | Missense_Mutation | novel | c.2240N>C | p.Gly747Ala | p.G747A | O95450 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | c.2834C>A | p.Pro945Gln | p.P945Q | O95450 | protein_coding | tolerated(0.07) | possibly_damaging(0.76) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ADAMTS2 | SNV | Missense_Mutation | c.2675N>T | p.Arg892Leu | p.R892L | O95450 | protein_coding | deleterious(0.01) | benign(0.22) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADAMTS2 | SNV | Missense_Mutation | rs200022037 | c.3343G>A | p.Asp1115Asn | p.D1115N | O95450 | protein_coding | tolerated(0.42) | benign(0.054) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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