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Gene: ZNF638 |
Gene summary for ZNF638 |
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Gene information | Species | Human | Gene symbol | ZNF638 | Gene ID | 27332 |
Gene name | zinc finger protein 638 | |
Gene Alias | NP220 | |
Cytomap | 2p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14966 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27332 | ZNF638 | CA_HPV_1 | Human | Cervix | CC | 8.14e-04 | -1.07e-01 | 0.0264 |
27332 | ZNF638 | CA_HPV_3 | Human | Cervix | CC | 5.52e-04 | -2.42e-02 | 0.0414 |
27332 | ZNF638 | CCI_1 | Human | Cervix | CC | 4.75e-04 | 1.10e+00 | 0.528 |
27332 | ZNF638 | CCI_2 | Human | Cervix | CC | 2.78e-04 | 7.13e-01 | 0.5249 |
27332 | ZNF638 | CCI_3 | Human | Cervix | CC | 5.11e-18 | 1.24e+00 | 0.516 |
27332 | ZNF638 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.37e-32 | -7.60e-01 | 0.0155 |
27332 | ZNF638 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.31e-12 | -5.86e-01 | -0.1808 |
27332 | ZNF638 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.75e-03 | -7.65e-01 | 0.0216 |
27332 | ZNF638 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.34e-03 | -5.94e-01 | -0.2196 |
27332 | ZNF638 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.03e-12 | -6.70e-01 | -0.1207 |
27332 | ZNF638 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.43e-03 | -4.20e-01 | -0.1526 |
27332 | ZNF638 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.85e-17 | -5.16e-01 | -0.1464 |
27332 | ZNF638 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.05e-13 | -4.59e-01 | -0.1001 |
27332 | ZNF638 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.45e-04 | -7.32e-01 | -0.2061 |
27332 | ZNF638 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.28e-02 | -6.39e-01 | -0.1462 |
27332 | ZNF638 | HTA11_9341_2000001011 | Human | Colorectum | SER | 6.69e-03 | -8.99e-01 | -0.00410000000000005 |
27332 | ZNF638 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.65e-04 | -5.41e-01 | -0.0179 |
27332 | ZNF638 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.11e-17 | -6.86e-01 | 0.096 |
27332 | ZNF638 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.17e-03 | -7.50e-01 | 0.0451 |
27332 | ZNF638 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.39e-06 | -6.79e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00083805 | Colorectum | CRC | RNA splicing | 90/2078 | 434/18723 | 2.80e-09 | 7.97e-07 | 90 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:00083807 | Liver | NAFLD | RNA splicing | 70/1882 | 434/18723 | 4.62e-05 | 1.10e-03 | 70 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:00083808 | Lung | IAC | RNA splicing | 75/2061 | 434/18723 | 4.89e-05 | 1.12e-03 | 75 |
GO:000838013 | Lung | AIS | RNA splicing | 68/1849 | 434/18723 | 8.50e-05 | 2.11e-03 | 68 |
GO:000838023 | Lung | MIAC | RNA splicing | 44/967 | 434/18723 | 1.56e-05 | 1.07e-03 | 44 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000838025 | Oral cavity | EOLP | RNA splicing | 115/2218 | 434/18723 | 2.24e-17 | 3.04e-14 | 115 |
GO:000838033 | Oral cavity | NEOLP | RNA splicing | 110/2005 | 434/18723 | 2.29e-18 | 2.72e-15 | 110 |
GO:000838018 | Prostate | BPH | RNA splicing | 147/3107 | 434/18723 | 5.17e-19 | 2.29e-16 | 147 |
GO:000838019 | Prostate | Tumor | RNA splicing | 153/3246 | 434/18723 | 9.15e-20 | 5.79e-17 | 153 |
GO:000838027 | Skin | AK | RNA splicing | 111/1910 | 434/18723 | 1.85e-20 | 5.49e-17 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF638 | SNV | Missense_Mutation | c.3506N>G | p.Thr1169Ser | p.T1169S | Q14966 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-G3-A7M5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF638 | SNV | Missense_Mutation | c.5500G>A | p.Val1834Ile | p.V1834I | Q14966 | protein_coding | tolerated(0.44) | benign(0.007) | TCGA-QA-A7B7-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF638 | insertion | Frame_Shift_Ins | novel | c.1721_1722insA | p.Ala577SerfsTer16 | p.A577Sfs*16 | Q14966 | protein_coding | TCGA-BD-A2L6-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF638 | SNV | Missense_Mutation | novel | c.1505N>T | p.Ser502Ile | p.S502I | Q14966 | protein_coding | deleterious(0.01) | possibly_damaging(0.467) | TCGA-05-4390-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF638 | SNV | Missense_Mutation | novel | c.5476N>A | p.Gln1826Lys | p.Q1826K | Q14966 | protein_coding | tolerated(0.28) | benign(0.039) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF638 | SNV | Missense_Mutation | c.5430G>C | p.Lys1810Asn | p.K1810N | Q14966 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-05-4415-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
ZNF638 | SNV | Missense_Mutation | novel | c.4306N>A | p.Glu1436Lys | p.E1436K | Q14966 | protein_coding | deleterious(0) | possibly_damaging(0.536) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF638 | SNV | Missense_Mutation | c.1916N>T | p.Cys639Phe | p.C639F | Q14966 | protein_coding | tolerated(0.65) | benign(0) | TCGA-44-2657-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF638 | SNV | Missense_Mutation | novel | c.3130A>T | p.Asn1044Tyr | p.N1044Y | Q14966 | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-44-7669-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | PD |
ZNF638 | SNV | Missense_Mutation | novel | c.1907N>G | p.Ser636Cys | p.S636C | Q14966 | protein_coding | tolerated(0.09) | benign(0) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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