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Gene: ZNF347 |
Gene summary for ZNF347 |
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Gene information | Species | Human | Gene symbol | ZNF347 | Gene ID | 84671 |
Gene name | zinc finger protein 347 | |
Gene Alias | ZNF1111 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R4L7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84671 | ZNF347 | HCC1_Meng | Human | Liver | HCC | 1.28e-10 | -1.56e-02 | 0.0246 |
84671 | ZNF347 | HCC1 | Human | Liver | HCC | 1.30e-02 | 1.53e+00 | 0.5336 |
84671 | ZNF347 | HCC2 | Human | Liver | HCC | 3.82e-05 | 2.17e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF347 | SNV | Missense_Mutation | novel | c.470T>C | p.Leu157Pro | p.L157P | Q96SE7 | protein_coding | tolerated(1) | probably_damaging(0.971) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF347 | SNV | Missense_Mutation | novel | c.107T>C | p.Val36Ala | p.V36A | Q96SE7 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ZNF347 | SNV | Missense_Mutation | novel | c.2357G>A | p.Arg786Lys | p.R786K | Q96SE7 | protein_coding | tolerated(0.11) | benign(0.129) | TCGA-VQ-A8PK-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ZNF347 | deletion | Frame_Shift_Del | rs747329533 | c.2208delN | p.Lys736AsnfsTer71 | p.K736Nfs*71 | Q96SE7 | protein_coding | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF347 | insertion | Nonsense_Mutation | novel | c.218_219insCTGGAAGGTGAAAGGATAAACT | p.Gln73HisfsTer7 | p.Q73Hfs*7 | Q96SE7 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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