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Gene: ZMYM3 |
Gene summary for ZMYM3 |
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Gene information | Species | Human | Gene symbol | ZMYM3 | Gene ID | 9203 |
Gene name | zinc finger MYM-type containing 3 | |
Gene Alias | DXS6673E | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q14202 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9203 | ZMYM3 | HCC1_Meng | Human | Liver | HCC | 1.62e-33 | 6.66e-02 | 0.0246 |
9203 | ZMYM3 | HCC2_Meng | Human | Liver | HCC | 1.70e-05 | 5.19e-02 | 0.0107 |
9203 | ZMYM3 | HCC1 | Human | Liver | HCC | 2.31e-02 | 3.13e+00 | 0.5336 |
9203 | ZMYM3 | HCC2 | Human | Liver | HCC | 8.33e-06 | 2.89e+00 | 0.5341 |
9203 | ZMYM3 | S014 | Human | Liver | HCC | 2.52e-07 | 4.06e-01 | 0.2254 |
9203 | ZMYM3 | S015 | Human | Liver | HCC | 2.33e-08 | 5.28e-01 | 0.2375 |
9203 | ZMYM3 | S016 | Human | Liver | HCC | 1.47e-06 | 3.73e-01 | 0.2243 |
9203 | ZMYM3 | S028 | Human | Liver | HCC | 7.75e-11 | 4.70e-01 | 0.2503 |
9203 | ZMYM3 | S029 | Human | Liver | HCC | 2.56e-03 | 3.30e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZMYM3 | SNV | Missense_Mutation | novel | c.1757N>T | p.Gly586Val | p.G586V | Q14202 | protein_coding | tolerated(0.16) | probably_damaging(0.91) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMYM3 | SNV | Missense_Mutation | c.3223G>T | p.Val1075Leu | p.V1075L | Q14202 | protein_coding | deleterious(0.02) | benign(0.16) | TCGA-55-A48X-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
ZMYM3 | SNV | Missense_Mutation | novel | c.3808N>A | p.Gly1270Ser | p.G1270S | Q14202 | protein_coding | tolerated(0.75) | benign(0.024) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZMYM3 | SNV | Missense_Mutation | c.3006N>C | p.Lys1002Asn | p.K1002N | Q14202 | protein_coding | deleterious(0.02) | possibly_damaging(0.78) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZMYM3 | SNV | Missense_Mutation | c.410N>A | p.Pro137His | p.P137H | Q14202 | protein_coding | deleterious_low_confidence(0.02) | benign(0.322) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZMYM3 | SNV | Missense_Mutation | novel | c.2718G>C | p.Leu906Phe | p.L906F | Q14202 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMYM3 | SNV | Missense_Mutation | c.2384N>G | p.Thr795Ser | p.T795S | Q14202 | protein_coding | tolerated(0.98) | benign(0) | TCGA-22-5480-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD | |
ZMYM3 | SNV | Missense_Mutation | c.481N>A | p.Glu161Lys | p.E161K | Q14202 | protein_coding | tolerated_low_confidence(1) | benign(0.055) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZMYM3 | SNV | Missense_Mutation | c.2493N>C | p.Lys831Asn | p.K831N | Q14202 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-39-5035-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZMYM3 | SNV | Missense_Mutation | c.1286A>C | p.His429Pro | p.H429P | Q14202 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-43-6770-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Vaccine | recprame+as15 | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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