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Gene: ZFPM2 |
Gene summary for ZFPM2 |
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Gene information | Species | Human | Gene symbol | ZFPM2 | Gene ID | 23414 |
Gene name | zinc finger protein, FOG family member 2 | |
Gene Alias | DIH3 | |
Cytomap | 8q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8WW38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23414 | ZFPM2 | AEH-subject1 | Human | Endometrium | AEH | 1.01e-04 | 1.83e-01 | -0.3059 |
23414 | ZFPM2 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 7.31e-03 | 6.84e-01 | -0.1271 |
23414 | ZFPM2 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 5.54e-03 | 7.27e-01 | -0.138 |
23414 | ZFPM2 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 8.87e-03 | 2.42e-01 | -0.2116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00614589 | Endometrium | AEH | reproductive system development | 88/2100 | 427/18723 | 9.50e-09 | 6.41e-07 | 88 |
GO:00486089 | Endometrium | AEH | reproductive structure development | 87/2100 | 424/18723 | 1.43e-08 | 9.12e-07 | 87 |
GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
GO:00017019 | Endometrium | AEH | in utero embryonic development | 73/2100 | 367/18723 | 7.18e-07 | 2.63e-05 | 73 |
GO:00147065 | Endometrium | AEH | striated muscle tissue development | 75/2100 | 384/18723 | 1.06e-06 | 3.62e-05 | 75 |
GO:00330022 | Endometrium | AEH | muscle cell proliferation | 51/2100 | 248/18723 | 1.26e-05 | 2.77e-04 | 51 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:00604853 | Endometrium | AEH | mesenchyme development | 54/2100 | 291/18723 | 1.34e-04 | 1.83e-03 | 54 |
GO:00465452 | Endometrium | AEH | development of primary female sexual characteristics | 24/2100 | 100/18723 | 2.27e-04 | 2.75e-03 | 24 |
GO:00085852 | Endometrium | AEH | female gonad development | 23/2100 | 95/18723 | 2.65e-04 | 3.09e-03 | 23 |
GO:00486387 | Endometrium | AEH | regulation of developmental growth | 58/2100 | 330/18723 | 3.45e-04 | 3.80e-03 | 58 |
GO:00030072 | Endometrium | AEH | heart morphogenesis | 45/2100 | 246/18723 | 6.41e-04 | 6.23e-03 | 45 |
GO:00466602 | Endometrium | AEH | female sex differentiation | 25/2100 | 114/18723 | 7.30e-04 | 6.99e-03 | 25 |
GO:0048738 | Endometrium | AEH | cardiac muscle tissue development | 43/2100 | 236/18723 | 9.06e-04 | 8.30e-03 | 43 |
GO:00486396 | Endometrium | AEH | positive regulation of developmental growth | 33/2100 | 174/18723 | 1.72e-03 | 1.38e-02 | 33 |
GO:00605414 | Endometrium | AEH | respiratory system development | 37/2100 | 203/18723 | 1.97e-03 | 1.54e-02 | 37 |
GO:00303246 | Endometrium | AEH | lung development | 33/2100 | 177/18723 | 2.30e-03 | 1.74e-02 | 33 |
GO:0035265 | Endometrium | AEH | organ growth | 33/2100 | 178/18723 | 2.53e-03 | 1.87e-02 | 33 |
GO:00459278 | Endometrium | AEH | positive regulation of growth | 44/2100 | 259/18723 | 3.28e-03 | 2.30e-02 | 44 |
GO:00303236 | Endometrium | AEH | respiratory tube development | 33/2100 | 181/18723 | 3.33e-03 | 2.32e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFPM2 | SNV | Missense_Mutation | c.888N>A | p.Ser296Arg | p.S296R | Q8WW38 | protein_coding | tolerated(1) | benign(0.031) | TCGA-49-4487-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZFPM2 | SNV | Missense_Mutation | c.766N>T | p.Gly256Cys | p.G256C | Q8WW38 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-4505-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZFPM2 | SNV | Missense_Mutation | c.1483G>T | p.Gly495Cys | p.G495C | Q8WW38 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-49-4510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZFPM2 | SNV | Missense_Mutation | c.1847N>T | p.Pro616Leu | p.P616L | Q8WW38 | protein_coding | deleterious(0.05) | benign(0.057) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
ZFPM2 | SNV | Missense_Mutation | c.129N>C | p.Glu43Asp | p.E43D | Q8WW38 | protein_coding | tolerated(0.25) | probably_damaging(0.956) | TCGA-50-5936-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD | |
ZFPM2 | SNV | Missense_Mutation | c.984N>G | p.Phe328Leu | p.F328L | Q8WW38 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
ZFPM2 | SNV | Missense_Mutation | c.1345C>G | p.Leu449Val | p.L449V | Q8WW38 | protein_coding | tolerated(0.47) | benign(0.115) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZFPM2 | SNV | Missense_Mutation | novel | c.2026N>A | p.Pro676Thr | p.P676T | Q8WW38 | protein_coding | tolerated(0.17) | benign(0.058) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
ZFPM2 | SNV | Missense_Mutation | c.2027N>T | p.Pro676Leu | p.P676L | Q8WW38 | protein_coding | tolerated(0.09) | benign(0.058) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD | |
ZFPM2 | SNV | Missense_Mutation | rs374581095 | c.1255N>A | p.Glu419Lys | p.E419K | Q8WW38 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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