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Gene: UBR3 |
Gene summary for UBR3 |
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Gene information | Species | Human | Gene symbol | UBR3 | Gene ID | 130507 |
Gene name | ubiquitin protein ligase E3 component n-recognin 3 | |
Gene Alias | ZNF650 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001967 | UniProtAcc | Q6ZT12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
130507 | UBR3 | CCI_1 | Human | Cervix | CC | 5.73e-04 | 6.21e-01 | 0.528 |
130507 | UBR3 | CCI_2 | Human | Cervix | CC | 5.26e-13 | 1.46e+00 | 0.5249 |
130507 | UBR3 | CCI_3 | Human | Cervix | CC | 5.06e-11 | 7.10e-01 | 0.516 |
130507 | UBR3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.42e-13 | -5.41e-01 | 0.0155 |
130507 | UBR3 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.11e-03 | -3.36e-01 | -0.1526 |
130507 | UBR3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.02e-03 | -3.07e-01 | -0.1464 |
130507 | UBR3 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.95e-05 | -2.93e-01 | -0.1001 |
130507 | UBR3 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.21e-06 | -4.89e-01 | 0.096 |
130507 | UBR3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.87e-08 | -4.29e-01 | 0.0674 |
130507 | UBR3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.62e-06 | -3.22e-01 | 0.294 |
130507 | UBR3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.66e-07 | -3.48e-01 | 0.3005 |
130507 | UBR3 | A015-C-203 | Human | Colorectum | FAP | 1.25e-37 | -5.60e-01 | -0.1294 |
130507 | UBR3 | A015-C-204 | Human | Colorectum | FAP | 2.58e-06 | -3.50e-01 | -0.0228 |
130507 | UBR3 | A014-C-040 | Human | Colorectum | FAP | 1.40e-05 | -5.85e-01 | -0.1184 |
130507 | UBR3 | A002-C-201 | Human | Colorectum | FAP | 1.22e-14 | -5.07e-01 | 0.0324 |
130507 | UBR3 | A002-C-203 | Human | Colorectum | FAP | 3.08e-05 | -2.48e-01 | 0.2786 |
130507 | UBR3 | A001-C-119 | Human | Colorectum | FAP | 1.66e-05 | -3.38e-01 | -0.1557 |
130507 | UBR3 | A001-C-108 | Human | Colorectum | FAP | 6.95e-18 | -3.28e-01 | -0.0272 |
130507 | UBR3 | A002-C-205 | Human | Colorectum | FAP | 1.03e-21 | -4.55e-01 | -0.1236 |
130507 | UBR3 | A001-C-104 | Human | Colorectum | FAP | 4.68e-08 | -2.35e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:00431614 | Colorectum | FAP | proteasome-mediated ubiquitin-dependent protein catabolic process | 98/2622 | 412/18723 | 5.41e-08 | 4.20e-06 | 98 |
GO:00104984 | Colorectum | FAP | proteasomal protein catabolic process | 110/2622 | 490/18723 | 2.12e-07 | 1.26e-05 | 110 |
GO:00431615 | Colorectum | CRC | proteasome-mediated ubiquitin-dependent protein catabolic process | 69/2078 | 412/18723 | 3.16e-04 | 4.90e-03 | 69 |
GO:00104985 | Colorectum | CRC | proteasomal protein catabolic process | 77/2078 | 490/18723 | 1.03e-03 | 1.21e-02 | 77 |
GO:00431617 | Liver | NAFLD | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/1882 | 412/18723 | 3.00e-13 | 1.75e-10 | 91 |
GO:00104987 | Liver | NAFLD | proteasomal protein catabolic process | 101/1882 | 490/18723 | 1.35e-12 | 6.09e-10 | 101 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:00104988 | Lung | IAC | proteasomal protein catabolic process | 90/2061 | 490/18723 | 6.69e-07 | 3.89e-05 | 90 |
GO:00431618 | Lung | IAC | proteasome-mediated ubiquitin-dependent protein catabolic process | 78/2061 | 412/18723 | 1.10e-06 | 6.02e-05 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBR3 | SNV | Missense_Mutation | novel | c.5614N>G | p.His1872Asp | p.H1872D | Q6ZT12 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-BB-A5HU-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
UBR3 | SNV | Missense_Mutation | novel | c.5215N>A | p.Glu1739Lys | p.E1739K | Q6ZT12 | protein_coding | tolerated(0.25) | benign(0.055) | TCGA-CN-A499-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBR3 | SNV | Missense_Mutation | novel | c.4600N>T | p.His1534Tyr | p.H1534Y | Q6ZT12 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-CQ-5326-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
UBR3 | SNV | Missense_Mutation | novel | c.4922N>T | p.Ser1641Phe | p.S1641F | Q6ZT12 | protein_coding | deleterious(0.02) | benign(0.229) | TCGA-CV-7252-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
UBR3 | SNV | Missense_Mutation | novel | c.5639N>C | p.Arg1880Thr | p.R1880T | Q6ZT12 | protein_coding | tolerated(0.68) | probably_damaging(0.966) | TCGA-P3-A5Q5-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR3 | SNV | Missense_Mutation | c.5140A>G | p.Ile1714Val | p.I1714V | Q6ZT12 | protein_coding | tolerated(0.88) | benign(0) | TCGA-EJ-5494-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
UBR3 | SNV | Missense_Mutation | c.4547T>A | p.Met1516Lys | p.M1516K | Q6ZT12 | protein_coding | tolerated(0.92) | benign(0) | TCGA-HC-7213-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD | |
UBR3 | insertion | Frame_Shift_Ins | novel | c.5304_5305insAG | p.Cys1769SerfsTer21 | p.C1769Sfs*21 | Q6ZT12 | protein_coding | TCGA-G9-6332-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD | ||
UBR3 | insertion | Frame_Shift_Ins | novel | c.5305_5306insGTCA | p.Thr1770GlnfsTer6 | p.T1770Qfs*6 | Q6ZT12 | protein_coding | TCGA-G9-6332-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD | ||
UBR3 | SNV | Missense_Mutation | rs748028932 | c.3452G>A | p.Arg1151His | p.R1151H | Q6ZT12 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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