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Gene: UBR1 |
Gene summary for UBR1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | UBR1 | Gene ID | 197131 |
Gene name | ubiquitin protein ligase E3 component n-recognin 1 | |
Gene Alias | JBS | |
Cytomap | 15q15.2 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | Q8IWV7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
197131 | UBR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.77e-08 | -3.80e-01 | 0.0155 |
197131 | UBR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.75e-02 | -2.51e-01 | 0.3005 |
197131 | UBR1 | F007 | Human | Colorectum | FAP | 1.01e-05 | -3.73e-01 | 0.1176 |
197131 | UBR1 | A015-C-203 | Human | Colorectum | FAP | 4.60e-21 | -4.28e-01 | -0.1294 |
197131 | UBR1 | A015-C-204 | Human | Colorectum | FAP | 1.09e-10 | -4.08e-01 | -0.0228 |
197131 | UBR1 | A014-C-040 | Human | Colorectum | FAP | 7.89e-04 | -3.05e-01 | -0.1184 |
197131 | UBR1 | A002-C-201 | Human | Colorectum | FAP | 3.00e-15 | -2.85e-01 | 0.0324 |
197131 | UBR1 | A002-C-203 | Human | Colorectum | FAP | 2.84e-02 | -2.03e-01 | 0.2786 |
197131 | UBR1 | A001-C-119 | Human | Colorectum | FAP | 4.55e-06 | -2.22e-01 | -0.1557 |
197131 | UBR1 | A001-C-108 | Human | Colorectum | FAP | 8.23e-10 | -2.26e-01 | -0.0272 |
197131 | UBR1 | A002-C-205 | Human | Colorectum | FAP | 1.76e-19 | -3.80e-01 | -0.1236 |
197131 | UBR1 | A015-C-005 | Human | Colorectum | FAP | 7.18e-07 | -2.90e-01 | -0.0336 |
197131 | UBR1 | A015-C-006 | Human | Colorectum | FAP | 1.24e-15 | -3.86e-01 | -0.0994 |
197131 | UBR1 | A015-C-106 | Human | Colorectum | FAP | 3.30e-08 | -2.06e-01 | -0.0511 |
197131 | UBR1 | A002-C-114 | Human | Colorectum | FAP | 4.04e-19 | -4.28e-01 | -0.1561 |
197131 | UBR1 | A015-C-104 | Human | Colorectum | FAP | 4.58e-23 | -4.07e-01 | -0.1899 |
197131 | UBR1 | A001-C-014 | Human | Colorectum | FAP | 2.62e-10 | -2.31e-01 | 0.0135 |
197131 | UBR1 | A002-C-016 | Human | Colorectum | FAP | 1.27e-15 | -3.23e-01 | 0.0521 |
197131 | UBR1 | A015-C-002 | Human | Colorectum | FAP | 2.86e-12 | -4.03e-01 | -0.0763 |
197131 | UBR1 | A001-C-203 | Human | Colorectum | FAP | 5.72e-08 | -2.75e-01 | -0.0481 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:0031929 | Colorectum | MSS | TOR signaling | 35/3467 | 126/18723 | 6.91e-03 | 4.44e-02 | 35 |
GO:00431614 | Colorectum | FAP | proteasome-mediated ubiquitin-dependent protein catabolic process | 98/2622 | 412/18723 | 5.41e-08 | 4.20e-06 | 98 |
GO:00104984 | Colorectum | FAP | proteasomal protein catabolic process | 110/2622 | 490/18723 | 2.12e-07 | 1.26e-05 | 110 |
GO:00431615 | Colorectum | CRC | proteasome-mediated ubiquitin-dependent protein catabolic process | 69/2078 | 412/18723 | 3.16e-04 | 4.90e-03 | 69 |
GO:00104985 | Colorectum | CRC | proteasomal protein catabolic process | 77/2078 | 490/18723 | 1.03e-03 | 1.21e-02 | 77 |
GO:00104988 | Lung | IAC | proteasomal protein catabolic process | 90/2061 | 490/18723 | 6.69e-07 | 3.89e-05 | 90 |
GO:00431618 | Lung | IAC | proteasome-mediated ubiquitin-dependent protein catabolic process | 78/2061 | 412/18723 | 1.10e-06 | 6.02e-05 | 78 |
GO:00011014 | Lung | IAC | response to acid chemical | 25/2061 | 135/18723 | 6.31e-03 | 4.51e-02 | 25 |
GO:004316113 | Lung | AIS | proteasome-mediated ubiquitin-dependent protein catabolic process | 77/1849 | 412/18723 | 2.74e-08 | 3.47e-06 | 77 |
GO:001049813 | Lung | AIS | proteasomal protein catabolic process | 87/1849 | 490/18723 | 4.15e-08 | 5.03e-06 | 87 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBR1 | SNV | Missense_Mutation | novel | c.1441N>C | p.Tyr481His | p.Y481H | Q8IWV7 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBR1 | insertion | Frame_Shift_Ins | novel | c.4232_4233insGA | p.Ala1412LysfsTer31 | p.A1412Kfs*31 | Q8IWV7 | protein_coding | TCGA-F7-8298-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
UBR1 | insertion | In_Frame_Ins | novel | c.4231_4232insATC | p.Val1410_Leu1411insTyr | p.V1410_L1411insY | Q8IWV7 | protein_coding | TCGA-F7-8298-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
UBR1 | SNV | Missense_Mutation | rs536630830 | c.4139G>A | p.Arg1380His | p.R1380H | Q8IWV7 | protein_coding | tolerated(0.06) | possibly_damaging(0.781) | TCGA-CH-5771-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
UBR1 | SNV | Missense_Mutation | c.5026G>C | p.Val1676Leu | p.V1676L | Q8IWV7 | protein_coding | tolerated(1) | probably_damaging(0.987) | TCGA-EJ-7784-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
UBR1 | SNV | Missense_Mutation | c.469N>C | p.Trp157Arg | p.W157R | Q8IWV7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBR1 | SNV | Missense_Mutation | rs375804838 | c.2680G>A | p.Val894Ile | p.V894I | Q8IWV7 | protein_coding | tolerated(0.97) | benign(0) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBR1 | SNV | Missense_Mutation | c.211N>C | p.Phe71Leu | p.F71L | Q8IWV7 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBR1 | SNV | Missense_Mutation | c.3095N>C | p.Lys1032Thr | p.K1032T | Q8IWV7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-8687-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
UBR1 | SNV | Missense_Mutation | rs550798440 | c.4969G>A | p.Ala1657Thr | p.A1657T | Q8IWV7 | protein_coding | tolerated(0.73) | probably_damaging(0.996) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
197131 | UBR1 | ENZYME | DEXAMETHASONE | DEXAMETHASONE | 17264220 |
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