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Gene: TTC17 |
Gene summary for TTC17 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TTC17 | Gene ID | 55761 |
Gene name | tetratricopeptide repeat domain 17 | |
Gene Alias | TTC17 | |
Cytomap | 11p12-p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q6MZP1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55761 | TTC17 | CCI_2 | Human | Cervix | CC | 2.09e-03 | 7.80e-01 | 0.5249 |
55761 | TTC17 | CCI_3 | Human | Cervix | CC | 3.39e-09 | 7.30e-01 | 0.516 |
55761 | TTC17 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.48e-32 | -7.73e-01 | 0.0155 |
55761 | TTC17 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-10 | -6.91e-01 | -0.1808 |
55761 | TTC17 | HTA11_2951_2000001011 | Human | Colorectum | AD | 7.49e-08 | -9.50e-01 | 0.0216 |
55761 | TTC17 | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.04e-04 | -6.76e-01 | -0.2196 |
55761 | TTC17 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.37e-16 | -8.97e-01 | -0.1207 |
55761 | TTC17 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.15e-03 | -5.43e-01 | -0.1526 |
55761 | TTC17 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.94e-16 | -5.54e-01 | -0.1464 |
55761 | TTC17 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.97e-03 | -3.42e-01 | -0.1001 |
55761 | TTC17 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.98e-09 | -8.08e-01 | -0.2061 |
55761 | TTC17 | HTA11_5216_2000001011 | Human | Colorectum | SER | 5.95e-05 | -7.95e-01 | -0.1462 |
55761 | TTC17 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.74e-04 | -7.16e-01 | -0.00410000000000005 |
55761 | TTC17 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.64e-04 | -4.91e-01 | -0.0179 |
55761 | TTC17 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.11e-19 | -7.49e-01 | 0.096 |
55761 | TTC17 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.33e-03 | -8.81e-01 | 0.0451 |
55761 | TTC17 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.91e-12 | -8.83e-01 | 0.0528 |
55761 | TTC17 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.39e-02 | -5.94e-01 | 0.0171 |
55761 | TTC17 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.43e-10 | -5.93e-01 | 0.0338 |
55761 | TTC17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.73e-10 | -4.78e-01 | 0.0674 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:00070151 | Colorectum | SER | actin filament organization | 134/2897 | 442/18723 | 1.39e-15 | 5.70e-13 | 134 |
GO:00081541 | Colorectum | SER | actin polymerization or depolymerization | 77/2897 | 218/18723 | 3.50e-13 | 1.19e-10 | 77 |
GO:00300411 | Colorectum | SER | actin filament polymerization | 70/2897 | 191/18723 | 5.39e-13 | 1.65e-10 | 70 |
GO:00512581 | Colorectum | SER | protein polymerization | 91/2897 | 297/18723 | 2.72e-11 | 5.06e-09 | 91 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00081542 | Colorectum | MSS | actin polymerization or depolymerization | 79/3467 | 218/18723 | 4.14e-10 | 3.49e-08 | 79 |
GO:00300412 | Colorectum | MSS | actin filament polymerization | 71/3467 | 191/18723 | 8.77e-10 | 6.92e-08 | 71 |
GO:00512582 | Colorectum | MSS | protein polymerization | 97/3467 | 297/18723 | 2.98e-09 | 2.07e-07 | 97 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
GO:00081544 | Colorectum | FAP | actin polymerization or depolymerization | 60/2622 | 218/18723 | 1.15e-07 | 7.43e-06 | 60 |
GO:00300414 | Colorectum | FAP | actin filament polymerization | 53/2622 | 191/18723 | 4.65e-07 | 2.46e-05 | 53 |
GO:00512584 | Colorectum | FAP | protein polymerization | 73/2622 | 297/18723 | 7.11e-07 | 3.32e-05 | 73 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC17 | SNV | Missense_Mutation | rs748330010 | c.3191C>T | p.Ala1064Val | p.A1064V | Q96AE7 | protein_coding | tolerated(0.13) | probably_damaging(0.985) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TTC17 | SNV | Missense_Mutation | rs770938541 | c.562N>T | p.Pro188Ser | p.P188S | Q96AE7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.554) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC17 | SNV | Missense_Mutation | c.1471N>A | p.Ala491Thr | p.A491T | Q96AE7 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-BR-6458-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
TTC17 | SNV | Missense_Mutation | rs749725093 | c.1603G>A | p.Glu535Lys | p.E535K | Q96AE7 | protein_coding | tolerated(0.72) | benign(0) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
TTC17 | SNV | Missense_Mutation | rs757564706 | c.3359N>T | p.Pro1120Leu | p.P1120L | Q96AE7 | protein_coding | deleterious(0) | possibly_damaging(0.617) | TCGA-CD-5804-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR |
TTC17 | SNV | Missense_Mutation | c.1519N>G | p.Thr507Ala | p.T507A | Q96AE7 | protein_coding | tolerated(0.82) | benign(0) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TTC17 | SNV | Missense_Mutation | rs533471959 | c.2402G>A | p.Arg801His | p.R801H | Q96AE7 | protein_coding | tolerated(0.05) | possibly_damaging(0.869) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TTC17 | SNV | Missense_Mutation | novel | c.2272N>G | p.Asn758Asp | p.N758D | Q96AE7 | protein_coding | tolerated(0.5) | possibly_damaging(0.489) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTC17 | insertion | In_Frame_Ins | novel | c.1176_1177insTTTTTT | p.Arg392_Asn393insPhePhe | p.R392_N393insFF | Q96AE7 | protein_coding | TCGA-BR-8486-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TTC17 | deletion | Frame_Shift_Del | c.2667delN | p.Lys891AsnfsTer21 | p.K891Nfs*21 | Q96AE7 | protein_coding | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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