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Gene: TNKS1BP1 |
Gene summary for TNKS1BP1 |
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Gene information | Species | Human | Gene symbol | TNKS1BP1 | Gene ID | 85456 |
Gene name | tankyrase 1 binding protein 1 | |
Gene Alias | TAB182 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | A0A024R542 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85456 | TNKS1BP1 | LZE4T | Human | Esophagus | ESCC | 1.39e-07 | 2.66e-01 | 0.0811 |
85456 | TNKS1BP1 | LZE7T | Human | Esophagus | ESCC | 4.40e-03 | 8.63e-03 | 0.0667 |
85456 | TNKS1BP1 | LZE8T | Human | Esophagus | ESCC | 2.48e-06 | 2.75e-01 | 0.067 |
85456 | TNKS1BP1 | LZE20T | Human | Esophagus | ESCC | 1.81e-03 | 5.14e-02 | 0.0662 |
85456 | TNKS1BP1 | LZE24T | Human | Esophagus | ESCC | 2.51e-11 | 3.05e-01 | 0.0596 |
85456 | TNKS1BP1 | P1T-E | Human | Esophagus | ESCC | 6.12e-10 | 3.30e-01 | 0.0875 |
85456 | TNKS1BP1 | P2T-E | Human | Esophagus | ESCC | 1.14e-11 | 3.39e-01 | 0.1177 |
85456 | TNKS1BP1 | P4T-E | Human | Esophagus | ESCC | 1.70e-18 | 5.23e-01 | 0.1323 |
85456 | TNKS1BP1 | P5T-E | Human | Esophagus | ESCC | 1.57e-16 | 2.62e-01 | 0.1327 |
85456 | TNKS1BP1 | P8T-E | Human | Esophagus | ESCC | 6.94e-24 | 5.99e-01 | 0.0889 |
85456 | TNKS1BP1 | P9T-E | Human | Esophagus | ESCC | 5.33e-10 | 3.27e-01 | 0.1131 |
85456 | TNKS1BP1 | P10T-E | Human | Esophagus | ESCC | 1.71e-05 | 1.95e-02 | 0.116 |
85456 | TNKS1BP1 | P11T-E | Human | Esophagus | ESCC | 2.89e-03 | 6.15e-01 | 0.1426 |
85456 | TNKS1BP1 | P12T-E | Human | Esophagus | ESCC | 1.38e-16 | 4.87e-01 | 0.1122 |
85456 | TNKS1BP1 | P15T-E | Human | Esophagus | ESCC | 2.60e-08 | 2.54e-01 | 0.1149 |
85456 | TNKS1BP1 | P16T-E | Human | Esophagus | ESCC | 3.04e-05 | -7.29e-02 | 0.1153 |
85456 | TNKS1BP1 | P17T-E | Human | Esophagus | ESCC | 1.37e-10 | 3.93e-01 | 0.1278 |
85456 | TNKS1BP1 | P19T-E | Human | Esophagus | ESCC | 1.11e-03 | 2.78e-01 | 0.1662 |
85456 | TNKS1BP1 | P20T-E | Human | Esophagus | ESCC | 1.59e-10 | 1.17e-01 | 0.1124 |
85456 | TNKS1BP1 | P21T-E | Human | Esophagus | ESCC | 7.78e-21 | 4.60e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001021217 | Esophagus | ESCC | response to ionizing radiation | 110/8552 | 148/18723 | 1.11e-12 | 4.78e-11 | 110 |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:000700418 | Esophagus | ESCC | telomere maintenance via telomerase | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:007147816 | Esophagus | ESCC | cellular response to radiation | 122/8552 | 186/18723 | 3.07e-08 | 5.73e-07 | 122 |
GO:001083319 | Esophagus | ESCC | telomere maintenance via telomere lengthening | 61/8552 | 81/18723 | 5.24e-08 | 9.37e-07 | 61 |
GO:000627816 | Esophagus | ESCC | RNA-dependent DNA biosynthetic process | 56/8552 | 75/18723 | 3.03e-07 | 4.30e-06 | 56 |
GO:0071479110 | Esophagus | ESCC | cellular response to ionizing radiation | 54/8552 | 72/18723 | 3.85e-07 | 5.32e-06 | 54 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
GO:00319521 | Esophagus | ESCC | regulation of protein autophosphorylation | 29/8552 | 43/18723 | 3.25e-03 | 1.35e-02 | 29 |
GO:00331355 | Esophagus | ESCC | regulation of peptidyl-serine phosphorylation | 81/8552 | 144/18723 | 6.79e-03 | 2.48e-02 | 81 |
GO:00319541 | Esophagus | ESCC | positive regulation of protein autophosphorylation | 19/8552 | 27/18723 | 8.35e-03 | 2.95e-02 | 19 |
GO:001810710 | Esophagus | ESCC | peptidyl-threonine phosphorylation | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.5151N>G | p.Asn1717Lys | p.N1717K | Q9C0C2 | protein_coding | deleterious(0.01) | benign(0.346) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.4597N>G | p.Ser1533Gly | p.S1533G | Q9C0C2 | protein_coding | tolerated(1) | benign(0) | TCGA-CX-A4AQ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TNKS1BP1 | SNV | Missense_Mutation | rs371891458 | c.4292N>C | p.Gly1431Ala | p.G1431A | Q9C0C2 | protein_coding | tolerated(0.13) | benign(0.094) | TCGA-D6-A6EN-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.158N>G | p.Leu53Arg | p.L53R | Q9C0C2 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-IQ-7630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.703N>C | p.Glu235Gln | p.E235Q | Q9C0C2 | protein_coding | deleterious(0.04) | possibly_damaging(0.882) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.4370N>C | p.Glu1457Ala | p.E1457A | Q9C0C2 | protein_coding | deleterious(0.01) | benign(0.186) | TCGA-UF-A71D-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.4945N>T | p.Pro1649Ser | p.P1649S | Q9C0C2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-J9-A8CP-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
TNKS1BP1 | SNV | Missense_Mutation | rs148640580 | c.2914G>A | p.Ala972Thr | p.A972T | Q9C0C2 | protein_coding | tolerated(0.45) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TNKS1BP1 | SNV | Missense_Mutation | novel | c.448C>T | p.Arg150Cys | p.R150C | Q9C0C2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TNKS1BP1 | SNV | Missense_Mutation | rs756294920 | c.5099N>T | p.Thr1700Met | p.T1700M | Q9C0C2 | protein_coding | deleterious(0) | benign(0.407) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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