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Gene: THSD7B |
Gene summary for THSD7B |
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Gene information | Species | Human | Gene symbol | THSD7B | Gene ID | 80731 |
Gene name | thrombospondin type 1 domain containing 7B | |
Gene Alias | THSD7B | |
Cytomap | 2q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | E7EM75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80731 | THSD7B | P2T-E | Human | Esophagus | ESCC | 1.17e-07 | 2.58e-01 | 0.1177 |
80731 | THSD7B | P12T-E | Human | Esophagus | ESCC | 1.29e-35 | 8.15e-01 | 0.1122 |
80731 | THSD7B | P16T-E | Human | Esophagus | ESCC | 3.10e-02 | 9.65e-02 | 0.1153 |
80731 | THSD7B | P56T-E | Human | Esophagus | ESCC | 3.89e-06 | 5.55e-01 | 0.1613 |
80731 | THSD7B | 048752_1579-all-cells | Human | Prostate | BPH | 5.27e-07 | 1.84e-01 | 0.1008 |
80731 | THSD7B | 052095_1628-all-cells | Human | Prostate | BPH | 1.63e-32 | 6.07e-01 | 0.1032 |
80731 | THSD7B | 052097_1595-all-cells | Human | Prostate | BPH | 1.08e-16 | 3.82e-01 | 0.0972 |
80731 | THSD7B | 052099_1652-all-cells | Human | Prostate | BPH | 7.83e-27 | 5.72e-01 | 0.1038 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003153218 | Esophagus | ESCC | actin cytoskeleton reorganization | 72/8552 | 107/18723 | 5.03e-06 | 5.31e-05 | 72 |
GO:003153210 | Prostate | BPH | actin cytoskeleton reorganization | 40/3107 | 107/18723 | 1.82e-07 | 4.04e-06 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THSD7B | SNV | Missense_Mutation | c.781C>A | p.Pro261Thr | p.P261T | protein_coding | tolerated(0.67) | benign(0.017) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
THSD7B | SNV | Missense_Mutation | c.2420N>A | p.Pro807His | p.P807H | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
THSD7B | SNV | Missense_Mutation | novel | c.1384G>A | p.Glu462Lys | p.E462K | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THSD7B | SNV | Missense_Mutation | rs367680913 | c.4693G>A | p.Ala1565Thr | p.A1565T | protein_coding | deleterious(0.01) | benign(0.102) | TCGA-D1-A1NS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THSD7B | SNV | Missense_Mutation | novel | c.3100N>A | p.Gly1034Arg | p.G1034R | protein_coding | tolerated(0.07) | probably_damaging(0.982) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
THSD7B | SNV | Missense_Mutation | rs370266523 | c.2183G>A | p.Arg728His | p.R728H | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-DI-A1NO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
THSD7B | SNV | Missense_Mutation | novel | c.76C>A | p.Leu26Ile | p.L26I | protein_coding | tolerated(0.18) | benign(0.02) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THSD7B | SNV | Missense_Mutation | c.610C>T | p.Arg204Cys | p.R204C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
THSD7B | SNV | Missense_Mutation | novel | c.731A>C | p.Lys244Thr | p.K244T | protein_coding | tolerated(0.08) | benign(0.168) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THSD7B | SNV | Missense_Mutation | novel | c.4091C>T | p.Ser1364Phe | p.S1364F | protein_coding | tolerated(0.43) | benign(0.009) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80731 | THSD7B | NA | ethanol | ALCOHOL | 32451486 |
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