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Gene: SCRIB |
Gene summary for SCRIB |
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Gene information | Species | Human | Gene symbol | SCRIB | Gene ID | 23513 |
Gene name | scribble planar cell polarity protein | |
Gene Alias | CRIB1 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A0G2JNZ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23513 | SCRIB | HTA11_347_2000001011 | Human | Colorectum | AD | 6.66e-06 | 2.04e-01 | -0.1954 |
23513 | SCRIB | HTA11_696_2000001011 | Human | Colorectum | AD | 1.16e-03 | 2.10e-01 | -0.1464 |
23513 | SCRIB | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.43e-05 | 3.45e-01 | -0.059 |
23513 | SCRIB | HTA11_866_3004761011 | Human | Colorectum | AD | 1.65e-02 | 1.64e-01 | 0.096 |
23513 | SCRIB | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.94e-09 | 3.23e-01 | 0.0674 |
23513 | SCRIB | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.84e-16 | 5.62e-01 | 0.3859 |
23513 | SCRIB | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.59e-18 | 5.61e-01 | 0.3005 |
23513 | SCRIB | LZE20T | Human | Esophagus | ESCC | 1.82e-07 | 2.63e-01 | 0.0662 |
23513 | SCRIB | LZE24T | Human | Esophagus | ESCC | 1.78e-07 | 1.84e-01 | 0.0596 |
23513 | SCRIB | P1T-E | Human | Esophagus | ESCC | 2.56e-10 | 3.47e-01 | 0.0875 |
23513 | SCRIB | P2T-E | Human | Esophagus | ESCC | 1.68e-07 | 1.17e-01 | 0.1177 |
23513 | SCRIB | P4T-E | Human | Esophagus | ESCC | 6.05e-09 | 6.09e-02 | 0.1323 |
23513 | SCRIB | P5T-E | Human | Esophagus | ESCC | 8.21e-12 | 1.29e-01 | 0.1327 |
23513 | SCRIB | P8T-E | Human | Esophagus | ESCC | 4.57e-14 | 2.27e-01 | 0.0889 |
23513 | SCRIB | P9T-E | Human | Esophagus | ESCC | 1.43e-13 | 1.97e-01 | 0.1131 |
23513 | SCRIB | P10T-E | Human | Esophagus | ESCC | 7.44e-08 | 1.04e-01 | 0.116 |
23513 | SCRIB | P12T-E | Human | Esophagus | ESCC | 1.26e-11 | 2.23e-01 | 0.1122 |
23513 | SCRIB | P15T-E | Human | Esophagus | ESCC | 2.11e-15 | 2.88e-01 | 0.1149 |
23513 | SCRIB | P16T-E | Human | Esophagus | ESCC | 6.31e-09 | 2.38e-01 | 0.1153 |
23513 | SCRIB | P17T-E | Human | Esophagus | ESCC | 2.21e-08 | 2.16e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0061951 | Colorectum | AD | establishment of protein localization to plasma membrane | 31/3918 | 60/18723 | 1.37e-07 | 6.42e-06 | 31 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0001881 | Colorectum | AD | receptor recycling | 18/3918 | 33/18723 | 2.23e-05 | 4.40e-04 | 18 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0061180 | Colorectum | AD | mammary gland epithelium development | 28/3918 | 67/18723 | 8.74e-05 | 1.35e-03 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa04530310 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0453042 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa051652 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0453052 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa051653 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCRIB | SNV | Missense_Mutation | c.3635N>A | p.Ala1212Glu | p.A1212E | Q14160 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
SCRIB | SNV | Missense_Mutation | rs538757774 | c.3145N>T | p.Arg1049Cys | p.R1049C | Q14160 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
SCRIB | SNV | Missense_Mutation | c.1591G>A | p.Val531Ile | p.V531I | Q14160 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
SCRIB | SNV | Missense_Mutation | rs782812033 | c.2573G>A | p.Arg858His | p.R858H | Q14160 | protein_coding | deleterious(0.02) | benign(0.059) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
SCRIB | SNV | Missense_Mutation | novel | c.4724N>A | p.Arg1575Lys | p.R1575K | Q14160 | protein_coding | deleterious_low_confidence(0.01) | benign(0.081) | TCGA-KB-A93G-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCRIB | SNV | Missense_Mutation | novel | c.1130T>C | p.Leu377Pro | p.L377P | Q14160 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SCRIB | SNV | Missense_Mutation | rs375530176 | c.383N>A | p.Arg128His | p.R128H | Q14160 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SCRIB | SNV | Missense_Mutation | c.1591G>A | p.Val531Ile | p.V531I | Q14160 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
SCRIB | deletion | Frame_Shift_Del | novel | c.2089delG | p.Ala697ProfsTer20 | p.A697Pfs*20 | Q14160 | protein_coding | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | ||
SCRIB | deletion | Frame_Shift_Del | c.2895delN | p.Thr966ProfsTer9 | p.T966Pfs*9 | Q14160 | protein_coding | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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