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Gene: PPRC1 |
Gene summary for PPRC1 |
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Gene information | Species | Human | Gene symbol | PPRC1 | Gene ID | 23082 |
Gene name | PPARG related coactivator 1 | |
Gene Alias | PRC | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | E7EVG6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23082 | PPRC1 | LZE4T | Human | Esophagus | ESCC | 1.65e-07 | -6.78e-02 | 0.0811 |
23082 | PPRC1 | LZE8T | Human | Esophagus | ESCC | 3.17e-04 | 8.68e-02 | 0.067 |
23082 | PPRC1 | LZE20T | Human | Esophagus | ESCC | 5.45e-03 | -1.34e-01 | 0.0662 |
23082 | PPRC1 | LZE22T | Human | Esophagus | ESCC | 3.51e-02 | -3.74e-02 | 0.068 |
23082 | PPRC1 | LZE24T | Human | Esophagus | ESCC | 2.75e-10 | 4.04e-01 | 0.0596 |
23082 | PPRC1 | P1T-E | Human | Esophagus | ESCC | 1.23e-10 | 8.31e-02 | 0.0875 |
23082 | PPRC1 | P2T-E | Human | Esophagus | ESCC | 1.34e-07 | 1.72e-01 | 0.1177 |
23082 | PPRC1 | P4T-E | Human | Esophagus | ESCC | 7.59e-07 | 7.98e-02 | 0.1323 |
23082 | PPRC1 | P5T-E | Human | Esophagus | ESCC | 1.20e-09 | 2.00e-01 | 0.1327 |
23082 | PPRC1 | P8T-E | Human | Esophagus | ESCC | 1.16e-10 | 6.72e-02 | 0.0889 |
23082 | PPRC1 | P9T-E | Human | Esophagus | ESCC | 1.05e-08 | 4.00e-03 | 0.1131 |
23082 | PPRC1 | P10T-E | Human | Esophagus | ESCC | 1.16e-09 | -1.05e-01 | 0.116 |
23082 | PPRC1 | P11T-E | Human | Esophagus | ESCC | 5.69e-06 | 2.23e-01 | 0.1426 |
23082 | PPRC1 | P12T-E | Human | Esophagus | ESCC | 1.36e-17 | 8.03e-02 | 0.1122 |
23082 | PPRC1 | P15T-E | Human | Esophagus | ESCC | 4.30e-09 | 1.56e-01 | 0.1149 |
23082 | PPRC1 | P16T-E | Human | Esophagus | ESCC | 2.06e-18 | 7.94e-02 | 0.1153 |
23082 | PPRC1 | P17T-E | Human | Esophagus | ESCC | 1.10e-05 | 1.28e-01 | 0.1278 |
23082 | PPRC1 | P20T-E | Human | Esophagus | ESCC | 1.65e-09 | 1.49e-01 | 0.1124 |
23082 | PPRC1 | P21T-E | Human | Esophagus | ESCC | 1.35e-16 | 1.11e-01 | 0.1617 |
23082 | PPRC1 | P22T-E | Human | Esophagus | ESCC | 4.72e-11 | -1.02e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
GO:00510913 | Liver | HCC | positive regulation of DNA-binding transcription factor activity | 131/7958 | 260/18723 | 5.98e-03 | 2.45e-02 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPRC1 | SNV | Missense_Mutation | novel | c.4027N>G | p.Pro1343Ala | p.P1343A | Q5VV67 | protein_coding | tolerated(0.81) | benign(0.01) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PPRC1 | SNV | Missense_Mutation | rs776378929 | c.4549N>T | p.Arg1517Trp | p.R1517W | Q5VV67 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PPRC1 | SNV | Missense_Mutation | rs756058587 | c.3026N>A | p.Arg1009Lys | p.R1009K | Q5VV67 | protein_coding | deleterious_low_confidence(0.05) | benign(0.104) | TCGA-DQ-5625-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PPRC1 | SNV | Missense_Mutation | novel | c.244N>A | p.Glu82Lys | p.E82K | Q5VV67 | protein_coding | deleterious_low_confidence(0) | benign(0.009) | TCGA-T2-A6WZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cetuximab | PD |
PPRC1 | SNV | Missense_Mutation | novel | c.4939G>C | p.Asp1647His | p.D1647H | Q5VV67 | protein_coding | deleterious(0.03) | benign(0.134) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
PPRC1 | SNV | Missense_Mutation | novel | c.4684A>G | p.Arg1562Gly | p.R1562G | Q5VV67 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-G9-7509-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD |
PPRC1 | SNV | Missense_Mutation | rs746405708 | c.3902G>A | p.Arg1301Gln | p.R1301Q | Q5VV67 | protein_coding | deleterious(0.02) | possibly_damaging(0.743) | TCGA-HC-7080-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | PD |
PPRC1 | SNV | Missense_Mutation | c.3893N>G | p.Tyr1298Cys | p.Y1298C | Q5VV67 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-J4-A67T-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
PPRC1 | SNV | Missense_Mutation | novel | c.2557N>T | p.Pro853Ser | p.P853S | Q5VV67 | protein_coding | tolerated_low_confidence(0.06) | benign(0.021) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PPRC1 | SNV | Missense_Mutation | rs201734122 | c.4469N>T | p.Ser1490Leu | p.S1490L | Q5VV67 | protein_coding | deleterious_low_confidence(0) | benign(0.416) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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