Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: LRRCC1

Gene summary for LRRCC1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

LRRCC1

Gene ID

85444

Gene nameleucine rich repeat and coiled-coil centrosomal protein 1
Gene AliasCLERC
Cytomap8q21.2
Gene Typeprotein-coding
GO ID

GO:0007049

UniProtAcc

B4DTJ0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
85444LRRCC1LZE2THumanEsophagusESCC2.69e-056.31e-010.082
85444LRRCC1LZE24THumanEsophagusESCC4.45e-093.08e-010.0596
85444LRRCC1P2T-EHumanEsophagusESCC2.68e-387.71e-010.1177
85444LRRCC1P4T-EHumanEsophagusESCC1.05e-296.74e-010.1323
85444LRRCC1P5T-EHumanEsophagusESCC9.80e-072.04e-010.1327
85444LRRCC1P8T-EHumanEsophagusESCC2.26e-092.31e-010.0889
85444LRRCC1P9T-EHumanEsophagusESCC2.15e-081.61e-010.1131
85444LRRCC1P10T-EHumanEsophagusESCC2.16e-143.06e-010.116
85444LRRCC1P11T-EHumanEsophagusESCC6.23e-155.97e-010.1426
85444LRRCC1P12T-EHumanEsophagusESCC9.54e-183.75e-010.1122
85444LRRCC1P15T-EHumanEsophagusESCC1.56e-051.87e-010.1149
85444LRRCC1P16T-EHumanEsophagusESCC1.06e-255.68e-010.1153
85444LRRCC1P17T-EHumanEsophagusESCC1.03e-073.08e-010.1278
85444LRRCC1P19T-EHumanEsophagusESCC1.68e-085.24e-010.1662
85444LRRCC1P20T-EHumanEsophagusESCC1.52e-061.50e-010.1124
85444LRRCC1P21T-EHumanEsophagusESCC1.18e-163.73e-010.1617
85444LRRCC1P22T-EHumanEsophagusESCC5.77e-092.16e-010.1236
85444LRRCC1P23T-EHumanEsophagusESCC9.65e-112.69e-010.108
85444LRRCC1P24T-EHumanEsophagusESCC3.02e-163.22e-010.1287
85444LRRCC1P26T-EHumanEsophagusESCC2.72e-101.99e-010.1276
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
LRRCC1insertionFrame_Shift_Insnovelc.646_647insCCGGAATp.Gln216ProfsTer13p.Q216Pfs*13Q9C099protein_codingTCGA-FY-A4B0-01Thyroidthyroid carcinomaMale>=65I/IIHormone TherapysynthroidSD
LRRCC1insertionFrame_Shift_Insnovelc.1528_1529insTACTp.Ala510ValfsTer11p.A510Vfs*11Q9C099protein_codingTCGA-FY-A4B0-01Thyroidthyroid carcinomaMale>=65I/IIHormone TherapysynthroidSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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