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Gene: LAMB4 |
Gene summary for LAMB4 |
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Gene information | Species | Human | Gene symbol | LAMB4 | Gene ID | 22798 |
Gene name | laminin subunit beta 4 | |
Gene Alias | LAMB4 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A4D0S4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22798 | LAMB4 | P4_S8_cSCC | Human | Skin | cSCC | 2.20e-38 | 7.42e-01 | -0.3095 |
22798 | LAMB4 | P1_cSCC | Human | Skin | cSCC | 1.06e-15 | 5.97e-01 | 0.0292 |
22798 | LAMB4 | P2_cSCC | Human | Skin | cSCC | 2.43e-06 | 2.45e-01 | -0.024 |
22798 | LAMB4 | P4_cSCC | Human | Skin | cSCC | 1.75e-05 | 2.13e-01 | -0.00290000000000005 |
22798 | LAMB4 | cSCC_p1 | Human | Skin | cSCC | 1.87e-06 | 3.05e-01 | -0.1916 |
22798 | LAMB4 | cSCC_p11 | Human | Skin | cSCC | 9.03e-08 | 3.29e-01 | -0.2102 |
22798 | LAMB4 | cSCC_p4 | Human | Skin | cSCC | 6.75e-13 | 3.60e-01 | -0.2022 |
22798 | LAMB4 | cSCC_p6 | Human | Skin | cSCC | 2.27e-05 | 2.23e-01 | -0.1989 |
22798 | LAMB4 | cSCC_p7 | Human | Skin | cSCC | 1.85e-02 | 2.76e-01 | -0.2332 |
22798 | LAMB4 | cSCC_p8 | Human | Skin | cSCC | 4.01e-10 | 2.40e-01 | -0.1971 |
22798 | LAMB4 | cSCC_p9 | Human | Skin | cSCC | 1.99e-11 | 2.52e-01 | -0.1991 |
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Tissue | Expression Dynamics | Abbreviation |
Skin | ![]() | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma | ||
SCCIS:squamous cell carcinoma in situ |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158926 | Skin | cSCC | cell-substrate adhesion | 130/4864 | 363/18723 | 1.87e-05 | 2.23e-04 | 130 |
GO:0034446110 | Skin | cSCC | substrate adhesion-dependent cell spreading | 43/4864 | 108/18723 | 1.12e-03 | 7.36e-03 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAMB4 | SNV | Missense_Mutation | c.134N>T | p.Ala45Val | p.A45V | A4D0S4 | protein_coding | deleterious(0.02) | benign(0.311) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LAMB4 | SNV | Missense_Mutation | novel | c.5085N>T | p.Gln1695His | p.Q1695H | A4D0S4 | protein_coding | deleterious(0.03) | possibly_damaging(0.62) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
LAMB4 | SNV | Missense_Mutation | novel | c.4696N>A | p.Leu1566Ile | p.L1566I | A4D0S4 | protein_coding | tolerated(0.07) | possibly_damaging(0.907) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
LAMB4 | SNV | Missense_Mutation | novel | c.2029N>C | p.Cys677Arg | p.C677R | A4D0S4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
LAMB4 | SNV | Missense_Mutation | novel | c.848A>C | p.Asp283Ala | p.D283A | A4D0S4 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
LAMB4 | SNV | Missense_Mutation | novel | c.373C>T | p.Arg125Trp | p.R125W | A4D0S4 | protein_coding | deleterious(0) | possibly_damaging(0.663) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
LAMB4 | SNV | Missense_Mutation | novel | c.3662N>T | p.Arg1221Ile | p.R1221I | A4D0S4 | protein_coding | deleterious(0.01) | benign(0.011) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LAMB4 | SNV | Missense_Mutation | c.1180N>T | p.Pro394Ser | p.P394S | A4D0S4 | protein_coding | tolerated(0.13) | probably_damaging(0.946) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
LAMB4 | SNV | Missense_Mutation | novel | c.4718T>C | p.Leu1573Ser | p.L1573S | A4D0S4 | protein_coding | tolerated(0.76) | benign(0.021) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAMB4 | SNV | Missense_Mutation | c.4288N>T | p.Arg1430Cys | p.R1430C | A4D0S4 | protein_coding | tolerated(0.06) | benign(0) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22798 | LAMB4 | DRUGGABLE GENOME | CHEMBL2095222 | OCRIPLASMIN |
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