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Gene: KDM5C |
Gene summary for KDM5C |
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Gene information | Species | Human | Gene symbol | KDM5C | Gene ID | 8242 |
Gene name | lysine demethylase 5C | |
Gene Alias | DXS1272E | |
Cytomap | Xp11.22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P41229 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8242 | KDM5C | LZE4T | Human | Esophagus | ESCC | 2.39e-05 | 8.70e-02 | 0.0811 |
8242 | KDM5C | LZE7T | Human | Esophagus | ESCC | 7.96e-06 | 4.00e-01 | 0.0667 |
8242 | KDM5C | LZE8T | Human | Esophagus | ESCC | 2.01e-07 | 2.90e-01 | 0.067 |
8242 | KDM5C | LZE20T | Human | Esophagus | ESCC | 9.10e-08 | 1.34e-01 | 0.0662 |
8242 | KDM5C | LZE24T | Human | Esophagus | ESCC | 5.52e-13 | 4.39e-01 | 0.0596 |
8242 | KDM5C | LZE21T | Human | Esophagus | ESCC | 4.50e-05 | 2.16e-01 | 0.0655 |
8242 | KDM5C | P1T-E | Human | Esophagus | ESCC | 2.52e-05 | 3.09e-01 | 0.0875 |
8242 | KDM5C | P2T-E | Human | Esophagus | ESCC | 1.34e-39 | 7.13e-01 | 0.1177 |
8242 | KDM5C | P4T-E | Human | Esophagus | ESCC | 1.53e-17 | 3.43e-01 | 0.1323 |
8242 | KDM5C | P5T-E | Human | Esophagus | ESCC | 3.61e-11 | 1.04e-01 | 0.1327 |
8242 | KDM5C | P8T-E | Human | Esophagus | ESCC | 1.04e-32 | 5.95e-01 | 0.0889 |
8242 | KDM5C | P9T-E | Human | Esophagus | ESCC | 2.83e-04 | 1.66e-01 | 0.1131 |
8242 | KDM5C | P10T-E | Human | Esophagus | ESCC | 4.17e-11 | 1.76e-01 | 0.116 |
8242 | KDM5C | P11T-E | Human | Esophagus | ESCC | 7.99e-14 | 5.35e-01 | 0.1426 |
8242 | KDM5C | P12T-E | Human | Esophagus | ESCC | 2.05e-05 | 1.44e-01 | 0.1122 |
8242 | KDM5C | P15T-E | Human | Esophagus | ESCC | 6.65e-14 | 2.45e-01 | 0.1149 |
8242 | KDM5C | P16T-E | Human | Esophagus | ESCC | 1.06e-18 | 3.43e-01 | 0.1153 |
8242 | KDM5C | P17T-E | Human | Esophagus | ESCC | 1.20e-07 | 3.77e-01 | 0.1278 |
8242 | KDM5C | P20T-E | Human | Esophagus | ESCC | 5.57e-08 | 1.91e-01 | 0.1124 |
8242 | KDM5C | P21T-E | Human | Esophagus | ESCC | 1.16e-11 | 1.25e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:004851118 | Esophagus | ESCC | rhythmic process | 164/8552 | 298/18723 | 6.80e-04 | 3.57e-03 | 164 |
GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00165773 | Esophagus | ESCC | histone demethylation | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00700763 | Esophagus | ESCC | histone lysine demethylation | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
GO:004851116 | Oral cavity | OSCC | rhythmic process | 157/7305 | 298/18723 | 1.00e-06 | 1.36e-05 | 157 |
GO:000963618 | Oral cavity | OSCC | response to toxic substance | 137/7305 | 262/18723 | 7.94e-06 | 8.52e-05 | 137 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:001657023 | Oral cavity | EOLP | histone modification | 98/2218 | 463/18723 | 5.58e-09 | 2.96e-07 | 98 |
GO:004851117 | Oral cavity | EOLP | rhythmic process | 69/2218 | 298/18723 | 2.68e-08 | 1.11e-06 | 69 |
GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
GO:000963625 | Oral cavity | EOLP | response to toxic substance | 48/2218 | 262/18723 | 1.37e-03 | 9.49e-03 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM5C | SNV | Missense_Mutation | c.142N>A | p.Pro48Thr | p.P48T | P41229 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KDM5C | insertion | Frame_Shift_Ins | novel | c.1801_1802insT | p.Tyr601LeufsTer21 | p.Y601Lfs*21 | P41229 | protein_coding | TCGA-55-8207-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
KDM5C | SNV | Missense_Mutation | c.632G>C | p.Arg211Pro | p.R211P | P41229 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-BA-A6DI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
KDM5C | SNV | Missense_Mutation | novel | c.2010N>T | p.Met670Ile | p.M670I | P41229 | protein_coding | deleterious(0.01) | benign(0.089) | TCGA-CN-A498-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
KDM5C | SNV | Missense_Mutation | novel | c.1009N>A | p.Asp337Asn | p.D337N | P41229 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CV-5442-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM5C | SNV | Missense_Mutation | novel | c.2318G>T | p.Trp773Leu | p.W773L | P41229 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D6-6823-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KDM5C | SNV | Missense_Mutation | novel | c.4061N>A | p.Gly1354Glu | p.G1354E | P41229 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-RS-A6TP-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KDM5C | insertion | Frame_Shift_Ins | novel | c.1403_1404insT | p.Glu468AspfsTer49 | p.E468Dfs*49 | P41229 | protein_coding | TCGA-CR-7367-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
KDM5C | insertion | Frame_Shift_Ins | novel | c.1128dupT | p.Lys377Ter | p.K377* | P41229 | protein_coding | TCGA-CV-A6JD-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KDM5C | SNV | Missense_Mutation | novel | c.1754G>A | p.Arg585His | p.R585H | P41229 | protein_coding | deleterious(0.02) | probably_damaging(0.929) | TCGA-VN-A88I-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 310264759 | ||
8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 178103605 | ||
8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | EVEROLIMUS | EVEROLIMUS | 27751729 | |
8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 249565909 | ||
8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 178103606 | ||
8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | SUNITINIB | SUNITINIB | 27751729 |
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