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Gene: ITPR2 |
Gene summary for ITPR2 |
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Gene information | Species | Human | Gene symbol | ITPR2 | Gene ID | 3709 |
Gene name | inositol 1,4,5-trisphosphate receptor type 2 | |
Gene Alias | ANHD | |
Cytomap | 12p11.23 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | Q14571 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3709 | ITPR2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.82e-06 | 3.98e-01 | -0.2602 |
3709 | ITPR2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.65e-05 | -3.31e-01 | 0.294 |
3709 | ITPR2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.92e-18 | 1.71e+00 | 0.3487 |
3709 | ITPR2 | F007 | Human | Colorectum | FAP | 1.57e-10 | 6.05e-01 | 0.1176 |
3709 | ITPR2 | A002-C-010 | Human | Colorectum | FAP | 3.41e-08 | 3.88e-01 | 0.242 |
3709 | ITPR2 | A001-C-207 | Human | Colorectum | FAP | 3.85e-26 | 8.53e-01 | 0.1278 |
3709 | ITPR2 | A015-C-203 | Human | Colorectum | FAP | 7.90e-29 | 4.30e-01 | -0.1294 |
3709 | ITPR2 | A015-C-204 | Human | Colorectum | FAP | 3.59e-06 | 8.95e-02 | -0.0228 |
3709 | ITPR2 | A014-C-040 | Human | Colorectum | FAP | 2.48e-06 | 4.87e-01 | -0.1184 |
3709 | ITPR2 | A002-C-201 | Human | Colorectum | FAP | 1.32e-12 | 2.38e-01 | 0.0324 |
3709 | ITPR2 | A001-C-119 | Human | Colorectum | FAP | 1.25e-66 | 1.26e+00 | -0.1557 |
3709 | ITPR2 | A001-C-108 | Human | Colorectum | FAP | 3.32e-46 | 8.59e-01 | -0.0272 |
3709 | ITPR2 | A002-C-021 | Human | Colorectum | FAP | 2.95e-20 | 6.60e-01 | 0.1171 |
3709 | ITPR2 | A002-C-205 | Human | Colorectum | FAP | 2.93e-39 | 6.92e-01 | -0.1236 |
3709 | ITPR2 | A014-C-108 | Human | Colorectum | FAP | 6.68e-03 | 2.97e-01 | -0.124 |
3709 | ITPR2 | A001-C-104 | Human | Colorectum | FAP | 1.24e-38 | 8.41e-01 | 0.0184 |
3709 | ITPR2 | A015-C-006 | Human | Colorectum | FAP | 2.60e-34 | 7.79e-01 | -0.0994 |
3709 | ITPR2 | A015-C-106 | Human | Colorectum | FAP | 2.32e-15 | 3.58e-01 | -0.0511 |
3709 | ITPR2 | A002-C-114 | Human | Colorectum | FAP | 2.31e-15 | 1.20e-01 | -0.1561 |
3709 | ITPR2 | A015-C-104 | Human | Colorectum | FAP | 5.67e-46 | 7.08e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00704821 | Colorectum | SER | response to oxygen levels | 79/2897 | 347/18723 | 1.99e-04 | 3.64e-03 | 79 |
GO:00016661 | Colorectum | SER | response to hypoxia | 69/2897 | 307/18723 | 7.07e-04 | 9.39e-03 | 69 |
GO:00362931 | Colorectum | SER | response to decreased oxygen levels | 71/2897 | 322/18723 | 1.04e-03 | 1.22e-02 | 71 |
GO:00713201 | Colorectum | SER | cellular response to cAMP | 16/2897 | 53/18723 | 5.09e-03 | 3.91e-02 | 16 |
GO:00516511 | Colorectum | SER | maintenance of location in cell | 47/2897 | 214/18723 | 7.20e-03 | 4.99e-02 | 47 |
GO:00973051 | Colorectum | MSS | response to alcohol | 66/3467 | 253/18723 | 1.73e-03 | 1.54e-02 | 66 |
GO:00516512 | Colorectum | MSS | maintenance of location in cell | 57/3467 | 214/18723 | 2.07e-03 | 1.76e-02 | 57 |
GO:00704822 | Colorectum | MSS | response to oxygen levels | 85/3467 | 347/18723 | 3.08e-03 | 2.34e-02 | 85 |
GO:00016662 | Colorectum | MSS | response to hypoxia | 75/3467 | 307/18723 | 5.56e-03 | 3.78e-02 | 75 |
GO:00973052 | Colorectum | MSI-H | response to alcohol | 33/1319 | 253/18723 | 4.53e-04 | 9.61e-03 | 33 |
GO:00704823 | Colorectum | FAP | response to oxygen levels | 77/2622 | 347/18723 | 2.08e-05 | 5.05e-04 | 77 |
GO:00016663 | Colorectum | FAP | response to hypoxia | 68/2622 | 307/18723 | 6.53e-05 | 1.25e-03 | 68 |
GO:00362932 | Colorectum | FAP | response to decreased oxygen levels | 70/2622 | 322/18723 | 9.49e-05 | 1.61e-03 | 70 |
GO:00515911 | Colorectum | FAP | response to cAMP | 27/2622 | 93/18723 | 1.26e-04 | 2.03e-03 | 27 |
GO:0046683 | Colorectum | FAP | response to organophosphorus | 33/2622 | 131/18723 | 4.61e-04 | 5.39e-03 | 33 |
GO:00973053 | Colorectum | FAP | response to alcohol | 55/2622 | 253/18723 | 5.05e-04 | 5.78e-03 | 55 |
GO:00713202 | Colorectum | FAP | cellular response to cAMP | 17/2622 | 53/18723 | 6.20e-04 | 6.82e-03 | 17 |
GO:0097306 | Colorectum | FAP | cellular response to alcohol | 25/2622 | 93/18723 | 7.87e-04 | 8.29e-03 | 25 |
GO:0014074 | Colorectum | FAP | response to purine-containing compound | 35/2622 | 148/18723 | 1.09e-03 | 1.05e-02 | 35 |
GO:00516513 | Colorectum | FAP | maintenance of location in cell | 46/2622 | 214/18723 | 1.76e-03 | 1.53e-02 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050202 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa050172 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
hsa047232 | Colorectum | SER | Retrograde endocannabinoid signaling | 47/1580 | 148/8465 | 8.10e-05 | 8.68e-04 | 6.30e-04 | 47 |
hsa049712 | Colorectum | SER | Gastric acid secretion | 27/1580 | 76/8465 | 3.65e-04 | 3.27e-03 | 2.38e-03 | 27 |
hsa052052 | Colorectum | SER | Proteoglycans in cancer | 58/1580 | 205/8465 | 4.37e-04 | 3.82e-03 | 2.77e-03 | 58 |
hsa051702 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa049282 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa047282 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
hsa049722 | Colorectum | SER | Pancreatic secretion | 30/1580 | 102/8465 | 5.41e-03 | 3.28e-02 | 2.38e-02 | 30 |
hsa04915 | Colorectum | SER | Estrogen signaling pathway | 38/1580 | 138/8465 | 6.51e-03 | 3.68e-02 | 2.67e-02 | 38 |
hsa051632 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
hsa047202 | Colorectum | SER | Long-term potentiation | 21/1580 | 67/8465 | 8.52e-03 | 4.26e-02 | 3.09e-02 | 21 |
hsa049122 | Colorectum | SER | GnRH signaling pathway | 27/1580 | 93/8465 | 9.68e-03 | 4.72e-02 | 3.43e-02 | 27 |
hsa050123 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050203 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITPR2 | SNV | Missense_Mutation | rs370610039 | c.6389N>T | p.Ser2130Leu | p.S2130L | Q14571 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | novel | c.5498N>A | p.Gly1833Asp | p.G1833D | Q14571 | protein_coding | deleterious(0.01) | possibly_damaging(0.616) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | rs765341825 | c.2887N>T | p.Asp963Tyr | p.D963Y | Q14571 | protein_coding | tolerated(0.12) | benign(0.238) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | novel | c.6494N>C | p.Val2165Ala | p.V2165A | Q14571 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | novel | c.2795T>C | p.Val932Ala | p.V932A | Q14571 | protein_coding | tolerated(0.29) | benign(0.265) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ITPR2 | SNV | Missense_Mutation | rs753089598 | c.4951N>A | p.Ala1651Thr | p.A1651T | Q14571 | protein_coding | deleterious(0.01) | benign(0.319) | TCGA-B5-A1N2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD |
ITPR2 | SNV | Missense_Mutation | novel | c.7805N>C | p.Lys2602Thr | p.K2602T | Q14571 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | novel | c.6535N>T | p.Arg2179Cys | p.R2179C | Q14571 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | novel | c.1612N>T | p.Leu538Phe | p.L538F | Q14571 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITPR2 | SNV | Missense_Mutation | novel | c.5844T>G | p.Asn1948Lys | p.N1948K | Q14571 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A3EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3709 | ITPR2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178101040 | ||
3709 | ITPR2 | ION CHANNEL, DRUGGABLE GENOME | antagonist | 135652750 | ||
3709 | ITPR2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178101039 | ||
3709 | ITPR2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178100946 | ||
3709 | ITPR2 | ION CHANNEL, DRUGGABLE GENOME | activator | 135652731 |
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