|
Gene: FER1L6 |
Gene summary for FER1L6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FER1L6 | Gene ID | 654463 |
Gene name | fer-1 like family member 6 | |
Gene Alias | C8ORFK23 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0007009 | UniProtAcc | Q2WGJ9 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
654463 | FER1L6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.01e-02 | 2.67e-01 | -0.1808 |
654463 | FER1L6 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.28e-05 | 3.49e-01 | -0.1088 |
654463 | FER1L6 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.63e-05 | 9.28e-01 | -0.2602 |
654463 | FER1L6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-04 | 9.70e-01 | -0.2196 |
654463 | FER1L6 | Pat02-B | Human | Stomach | GC | 1.08e-13 | 3.34e-01 | 0.0368 |
654463 | FER1L6 | Pat03-B | Human | Stomach | GC | 1.84e-03 | 2.43e-01 | 0.3693 |
654463 | FER1L6 | Pat04-B | Human | Stomach | GC | 1.80e-12 | 3.94e-01 | -0.1483 |
654463 | FER1L6 | Pat05-B | Human | Stomach | GC | 2.01e-02 | 2.30e-01 | -0.0353 |
654463 | FER1L6 | Pat06-B | Human | Stomach | GC | 9.30e-09 | 2.45e-01 | -0.1961 |
654463 | FER1L6 | Pat10-B | Human | Stomach | GC | 2.06e-06 | 4.79e-01 | 0.084 |
654463 | FER1L6 | Pat11-B | Human | Stomach | GC | 3.43e-07 | 2.68e-01 | -0.182 |
654463 | FER1L6 | Pat13-B | Human | Stomach | GC | 1.66e-05 | 3.41e-01 | 0.0555 |
654463 | FER1L6 | Pat15-B | Human | Stomach | GC | 4.46e-06 | 3.13e-01 | -0.0778 |
654463 | FER1L6 | Pat18-B | Human | Stomach | GC | 4.35e-23 | 6.07e-01 | -0.0432 |
654463 | FER1L6 | Pat19-B | Human | Stomach | GC | 2.04e-08 | 3.47e-01 | 0.0826 |
654463 | FER1L6 | Pat22-B | Human | Stomach | GC | 1.24e-16 | 3.94e-01 | -0.1042 |
654463 | FER1L6 | Pat24-B | Human | Stomach | GC | 3.34e-05 | 2.87e-01 | -0.1184 |
654463 | FER1L6 | Pat25-A | Human | Stomach | CAG with IM | 2.85e-11 | 2.25e-01 | -0.1648 |
654463 | FER1L6 | Pat26-A | Human | Stomach | CSG | 4.59e-13 | 2.69e-01 | -0.2402 |
654463 | FER1L6 | Pat28-A | Human | Stomach | CSG | 5.25e-08 | 2.70e-01 | -0.2594 |
Page: 1 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007009 | Colorectum | SER | plasma membrane organization | 36/2897 | 142/18723 | 1.50e-03 | 1.62e-02 | 36 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FER1L6 | SNV | Missense_Mutation | novel | c.2060A>C | p.Lys687Thr | p.K687T | Q2WGJ9 | protein_coding | tolerated(0.3) | benign(0.089) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FER1L6 | SNV | Missense_Mutation | novel | c.968N>C | p.Ile323Thr | p.I323T | Q2WGJ9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
FER1L6 | SNV | Missense_Mutation | novel | c.5029A>G | p.Asn1677Asp | p.N1677D | Q2WGJ9 | protein_coding | deleterious(0.04) | possibly_damaging(0.545) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
FER1L6 | SNV | Missense_Mutation | novel | c.628G>T | p.Gly210Cys | p.G210C | Q2WGJ9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FER1L6 | SNV | Missense_Mutation | novel | c.3329A>C | p.Asp1110Ala | p.D1110A | Q2WGJ9 | protein_coding | tolerated(0.73) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FER1L6 | SNV | Missense_Mutation | novel | c.3767A>T | p.Lys1256Met | p.K1256M | Q2WGJ9 | protein_coding | deleterious(0.01) | benign(0.024) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FER1L6 | SNV | Missense_Mutation | rs768839478 | c.4091C>T | p.Ala1364Val | p.A1364V | Q2WGJ9 | protein_coding | deleterious(0.04) | probably_damaging(0.933) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FER1L6 | SNV | Missense_Mutation | c.29N>A | p.Arg10Lys | p.R10K | Q2WGJ9 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FER1L6 | SNV | Missense_Mutation | rs200333104 | c.3142N>A | p.Glu1048Lys | p.E1048K | Q2WGJ9 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FER1L6 | SNV | Missense_Mutation | rs370827754 | c.278N>A | p.Arg93His | p.R93H | Q2WGJ9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |