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Gene: DENND2A |
Gene summary for DENND2A |
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Gene information | Species | Human | Gene symbol | DENND2A | Gene ID | 27147 |
Gene name | DENN domain containing 2A | |
Gene Alias | FAM31D | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9ULE3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27147 | DENND2A | HCC1 | Human | Liver | HCC | 1.06e-25 | 2.78e+00 | 0.5336 |
27147 | DENND2A | HCC2 | Human | Liver | HCC | 1.52e-34 | 2.23e+00 | 0.5341 |
27147 | DENND2A | HCC5 | Human | Liver | HCC | 7.27e-29 | 1.96e+00 | 0.4932 |
27147 | DENND2A | ATC11 | Human | Thyroid | ATC | 1.60e-07 | 5.38e-01 | 0.3386 |
27147 | DENND2A | ATC12 | Human | Thyroid | ATC | 2.76e-08 | 2.02e-01 | 0.34 |
27147 | DENND2A | ATC13 | Human | Thyroid | ATC | 9.88e-36 | 5.67e-01 | 0.34 |
27147 | DENND2A | ATC3 | Human | Thyroid | ATC | 3.03e-13 | 6.07e-01 | 0.338 |
27147 | DENND2A | ATC4 | Human | Thyroid | ATC | 1.14e-11 | 2.58e-01 | 0.34 |
27147 | DENND2A | ATC5 | Human | Thyroid | ATC | 2.95e-31 | 6.11e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:001648221 | Liver | HCC | cytosolic transport | 117/7958 | 168/18723 | 8.83e-13 | 4.48e-11 | 117 |
GO:004214721 | Liver | HCC | retrograde transport, endosome to Golgi | 61/7958 | 91/18723 | 1.94e-06 | 2.68e-05 | 61 |
GO:001619719 | Thyroid | ATC | endosomal transport | 128/6293 | 230/18723 | 4.44e-12 | 1.75e-10 | 128 |
GO:001648218 | Thyroid | ATC | cytosolic transport | 93/6293 | 168/18723 | 5.19e-09 | 1.15e-07 | 93 |
GO:004214715 | Thyroid | ATC | retrograde transport, endosome to Golgi | 49/6293 | 91/18723 | 5.48e-05 | 4.23e-04 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND2A | SNV | Missense_Mutation | rs747667851 | c.2788C>T | p.Arg930Trp | p.R930W | Q9ULE3 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DENND2A | SNV | Missense_Mutation | c.1628T>C | p.Leu543Pro | p.L543P | Q9ULE3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
DENND2A | SNV | Missense_Mutation | rs752648671 | c.1156A>G | p.Ile386Val | p.I386V | Q9ULE3 | protein_coding | tolerated(0.61) | benign(0.006) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DENND2A | SNV | Missense_Mutation | c.1514N>C | p.Gln505Pro | p.Q505P | Q9ULE3 | protein_coding | tolerated(0.24) | benign(0.067) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DENND2A | SNV | Missense_Mutation | c.1214N>T | p.Pro405Leu | p.P405L | Q9ULE3 | protein_coding | deleterious(0.04) | benign(0.014) | TCGA-HU-8604-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | doxifluridine | SD | |
DENND2A | SNV | Missense_Mutation | rs745399243 | c.2554N>A | p.Asp852Asn | p.D852N | Q9ULE3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
DENND2A | SNV | Missense_Mutation | novel | c.440N>A | p.Leu147His | p.L147H | Q9ULE3 | protein_coding | tolerated(0.54) | possibly_damaging(0.682) | TCGA-VQ-A8P3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
DENND2A | SNV | Missense_Mutation | novel | c.1419N>G | p.Asn473Lys | p.N473K | Q9ULE3 | protein_coding | deleterious(0.01) | possibly_damaging(0.669) | TCGA-VQ-A928-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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