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Gene: CUL9 |
Gene summary for CUL9 |
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Gene information | Species | Human | Gene symbol | CUL9 | Gene ID | 23113 |
Gene name | cullin 9 | |
Gene Alias | H7AP1 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8IWT3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23113 | CUL9 | male-WTA | Human | Thyroid | PTC | 4.25e-03 | 7.50e-02 | 0.1037 |
23113 | CUL9 | PTC04 | Human | Thyroid | PTC | 6.69e-05 | 9.05e-02 | 0.1927 |
23113 | CUL9 | PTC05 | Human | Thyroid | PTC | 5.59e-04 | 2.11e-01 | 0.2065 |
23113 | CUL9 | PTC06 | Human | Thyroid | PTC | 7.40e-06 | 1.99e-01 | 0.2057 |
23113 | CUL9 | PTC07 | Human | Thyroid | PTC | 3.79e-10 | 1.17e-01 | 0.2044 |
23113 | CUL9 | ATC13 | Human | Thyroid | ATC | 3.00e-34 | 5.34e-01 | 0.34 |
23113 | CUL9 | ATC2 | Human | Thyroid | ATC | 6.46e-06 | 4.80e-01 | 0.34 |
23113 | CUL9 | ATC5 | Human | Thyroid | ATC | 2.52e-37 | 5.72e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000734619 | Thyroid | PTC | regulation of mitotic cell cycle | 212/5968 | 457/18723 | 4.03e-11 | 1.44e-09 | 212 |
GO:01400148 | Thyroid | PTC | mitotic nuclear division | 135/5968 | 287/18723 | 4.90e-08 | 1.04e-06 | 135 |
GO:00482855 | Thyroid | PTC | organelle fission | 188/5968 | 488/18723 | 9.64e-04 | 5.77e-03 | 188 |
GO:00070885 | Thyroid | PTC | regulation of mitotic nuclear division | 51/5968 | 110/18723 | 1.02e-03 | 6.07e-03 | 51 |
GO:00002804 | Thyroid | PTC | nuclear division | 167/5968 | 439/18723 | 3.27e-03 | 1.60e-02 | 167 |
GO:00517833 | Thyroid | PTC | regulation of nuclear division | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
GO:000734622 | Thyroid | ATC | regulation of mitotic cell cycle | 236/6293 | 457/18723 | 7.58e-16 | 5.92e-14 | 236 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:000708811 | Thyroid | ATC | regulation of mitotic nuclear division | 67/6293 | 110/18723 | 3.98e-09 | 9.08e-08 | 67 |
GO:005178311 | Thyroid | ATC | regulation of nuclear division | 77/6293 | 139/18723 | 1.01e-07 | 1.70e-06 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CUL9 | SNV | Missense_Mutation | rs142672693 | c.2687N>T | p.Thr896Met | p.T896M | Q8IWT3 | protein_coding | deleterious(0.01) | possibly_damaging(0.469) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | c.3548N>T | p.Ser1183Ile | p.S1183I | Q8IWT3 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CUL9 | SNV | Missense_Mutation | c.5786N>A | p.Cys1929Tyr | p.C1929Y | Q8IWT3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CUL9 | SNV | Missense_Mutation | rs146080256 | c.4597G>A | p.Ala1533Thr | p.A1533T | Q8IWT3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | rs532403631 | c.247N>T | p.Arg83Trp | p.R83W | Q8IWT3 | protein_coding | tolerated(0.09) | benign(0) | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | novel | c.1069N>G | p.Arg357Gly | p.R357G | Q8IWT3 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CUL9 | SNV | Missense_Mutation | c.947N>A | p.Ser316Asn | p.S316N | Q8IWT3 | protein_coding | tolerated(0.06) | benign(0) | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CUL9 | SNV | Missense_Mutation | rs753868287 | c.80N>A | p.Arg27Gln | p.R27Q | Q8IWT3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CUL9 | SNV | Missense_Mutation | c.589N>A | p.Asp197Asn | p.D197N | Q8IWT3 | protein_coding | deleterious(0.01) | benign(0.041) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CUL9 | SNV | Missense_Mutation | novel | c.3970N>A | p.Ala1324Thr | p.A1324T | Q8IWT3 | protein_coding | tolerated(0.56) | possibly_damaging(0.842) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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