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Gene: COPA |
Gene summary for COPA |
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Gene information | Species | Human | Gene symbol | COPA | Gene ID | 1314 |
Gene name | COPI coat complex subunit alpha | |
Gene Alias | AILJK | |
Cytomap | 1q23.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P53621 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1314 | COPA | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.14e-09 | 6.96e-01 | -0.0811 |
1314 | COPA | HTA11_78_2000001011 | Human | Colorectum | AD | 1.45e-08 | 6.14e-01 | -0.1088 |
1314 | COPA | HTA11_347_2000001011 | Human | Colorectum | AD | 7.30e-25 | 8.82e-01 | -0.1954 |
1314 | COPA | HTA11_411_2000001011 | Human | Colorectum | SER | 3.51e-04 | 7.43e-01 | -0.2602 |
1314 | COPA | HTA11_696_2000001011 | Human | Colorectum | AD | 3.05e-03 | 5.12e-01 | -0.1464 |
1314 | COPA | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.03e-09 | 7.04e-01 | -0.059 |
1314 | COPA | HTA11_866_3004761011 | Human | Colorectum | AD | 1.49e-07 | 4.47e-01 | 0.096 |
1314 | COPA | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.34e-02 | 4.62e-01 | 0.0131 |
1314 | COPA | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.28e-02 | 5.58e-01 | -0.0124 |
1314 | COPA | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.59e-03 | 4.03e-01 | 0.0588 |
1314 | COPA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.34e-07 | 6.27e-01 | 0.294 |
1314 | COPA | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.42e-18 | 9.28e-01 | 0.281 |
1314 | COPA | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.60e-10 | 8.72e-01 | 0.3859 |
1314 | COPA | A002-C-010 | Human | Colorectum | FAP | 1.23e-02 | -1.59e-01 | 0.242 |
1314 | COPA | A015-C-203 | Human | Colorectum | FAP | 1.28e-20 | -3.65e-01 | -0.1294 |
1314 | COPA | A014-C-040 | Human | Colorectum | FAP | 1.41e-03 | -5.21e-01 | -0.1184 |
1314 | COPA | A002-C-201 | Human | Colorectum | FAP | 8.57e-09 | -2.34e-01 | 0.0324 |
1314 | COPA | A002-C-203 | Human | Colorectum | FAP | 6.40e-04 | -8.64e-02 | 0.2786 |
1314 | COPA | A001-C-108 | Human | Colorectum | FAP | 2.61e-15 | -3.02e-01 | -0.0272 |
1314 | COPA | A002-C-205 | Human | Colorectum | FAP | 3.46e-17 | -4.86e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006890 | Colorectum | AD | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 27/3918 | 52/18723 | 7.67e-07 | 2.70e-05 | 27 |
GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:0007589 | Colorectum | AD | body fluid secretion | 33/3918 | 93/18723 | 8.26e-04 | 8.13e-03 | 33 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00068901 | Colorectum | SER | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 20/2897 | 52/18723 | 4.80e-05 | 1.18e-03 | 20 |
GO:0022600 | Colorectum | SER | digestive system process | 29/2897 | 104/18723 | 8.57e-04 | 1.05e-02 | 29 |
GO:00068881 | Colorectum | SER | endoplasmic reticulum to Golgi vesicle-mediated transport | 34/2897 | 130/18723 | 1.13e-03 | 1.29e-02 | 34 |
GO:00508781 | Colorectum | SER | regulation of body fluid levels | 81/2897 | 379/18723 | 1.28e-03 | 1.43e-02 | 81 |
GO:00075891 | Colorectum | SER | body fluid secretion | 26/2897 | 93/18723 | 1.49e-03 | 1.60e-02 | 26 |
GO:0032941 | Colorectum | SER | secretion by tissue | 13/2897 | 38/18723 | 3.40e-03 | 2.90e-02 | 13 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00068902 | Colorectum | MSS | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 26/3467 | 52/18723 | 2.66e-07 | 1.10e-05 | 26 |
GO:00068882 | Colorectum | MSS | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3467 | 130/18723 | 2.17e-05 | 4.60e-04 | 44 |
GO:00508782 | Colorectum | MSS | regulation of body fluid levels | 99/3467 | 379/18723 | 1.40e-04 | 2.07e-03 | 99 |
GO:00075892 | Colorectum | MSS | body fluid secretion | 29/3467 | 93/18723 | 2.21e-03 | 1.84e-02 | 29 |
GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
GO:00481934 | Colorectum | FAP | Golgi vesicle transport | 77/2622 | 296/18723 | 2.86e-08 | 2.62e-06 | 77 |
GO:00068904 | Colorectum | FAP | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 18/2622 | 52/18723 | 1.48e-04 | 2.29e-03 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COPA | SNV | Missense_Mutation | novel | c.209G>C | p.Gly70Ala | p.G70A | P53621 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
COPA | SNV | Missense_Mutation | c.2177G>A | p.Arg726His | p.R726H | P53621 | protein_coding | tolerated(0.08) | possibly_damaging(0.895) | TCGA-DQ-7588-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | erbitux | PD | |
COPA | SNV | Missense_Mutation | novel | c.439N>A | p.Glu147Lys | p.E147K | P53621 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-MT-A67D-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COPA | SNV | Missense_Mutation | novel | c.1627G>A | p.Ala543Thr | p.A543T | P53621 | protein_coding | tolerated(0.24) | benign(0.377) | TCGA-QK-A6IJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
COPA | SNV | Missense_Mutation | novel | c.190C>T | p.Pro64Ser | p.P64S | P53621 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
COPA | SNV | Missense_Mutation | rs750545966 | c.2719N>A | p.Ala907Thr | p.A907T | P53621 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-BR-6457-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | CR |
COPA | SNV | Missense_Mutation | c.1847N>C | p.Lys616Thr | p.K616T | P53621 | protein_coding | tolerated(0.08) | benign(0.237) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
COPA | SNV | Missense_Mutation | rs767740500 | c.1612C>T | p.Arg538Cys | p.R538C | P53621 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
COPA | SNV | Missense_Mutation | c.2084N>G | p.Asn695Ser | p.N695S | P53621 | protein_coding | deleterious(0.01) | possibly_damaging(0.492) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
COPA | SNV | Missense_Mutation | c.1937N>C | p.Val646Ala | p.V646A | P53621 | protein_coding | deleterious(0) | possibly_damaging(0.45) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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