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Gene: CLSTN2 |
Gene summary for CLSTN2 |
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Gene information | Species | Human | Gene symbol | CLSTN2 | Gene ID | 64084 |
Gene name | calsyntenin 2 | |
Gene Alias | ALC-GAMMA | |
Cytomap | 3q23 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9H4D0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64084 | CLSTN2 | S014 | Human | Liver | HCC | 6.80e-12 | 5.15e-01 | 0.2254 |
64084 | CLSTN2 | S015 | Human | Liver | HCC | 9.93e-07 | 4.33e-01 | 0.2375 |
64084 | CLSTN2 | S016 | Human | Liver | HCC | 1.36e-20 | 5.89e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLSTN2 | SNV | Missense_Mutation | c.2204N>A | p.Ser735Tyr | p.S735Y | Q9H4D0 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-CN-A49A-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
CLSTN2 | SNV | Missense_Mutation | rs192974178 | c.1951N>C | p.Glu651Gln | p.E651Q | Q9H4D0 | protein_coding | tolerated(0.07) | benign(0.302) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
CLSTN2 | SNV | Missense_Mutation | rs762157350 | c.1318N>A | p.Ala440Thr | p.A440T | Q9H4D0 | protein_coding | deleterious(0.03) | possibly_damaging(0.751) | TCGA-CV-7411-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLSTN2 | SNV | Missense_Mutation | rs773695781 | c.1720G>A | p.Asp574Asn | p.D574N | Q9H4D0 | protein_coding | tolerated(0.2) | probably_damaging(0.996) | TCGA-CV-7446-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CLSTN2 | SNV | Missense_Mutation | novel | c.2377N>C | p.Asp793His | p.D793H | Q9H4D0 | protein_coding | tolerated(0.05) | benign(0.188) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CLSTN2 | deletion | Frame_Shift_Del | novel | c.388delN | p.Gly130ValfsTer21 | p.G130Vfs*21 | Q9H4D0 | protein_coding | TCGA-CV-5441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CLSTN2 | deletion | Frame_Shift_Del | novel | c.843delC | p.Ser282AlafsTer73 | p.S282Afs*73 | Q9H4D0 | protein_coding | TCGA-CV-7247-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
CLSTN2 | SNV | Missense_Mutation | c.431C>T | p.Ala144Val | p.A144V | Q9H4D0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EJ-5514-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
CLSTN2 | SNV | Missense_Mutation | rs137889465 | c.2005N>A | p.Ala669Thr | p.A669T | Q9H4D0 | protein_coding | tolerated(1) | benign(0) | TCGA-EJ-7315-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
CLSTN2 | SNV | Missense_Mutation | novel | c.1661N>A | p.Gly554Asp | p.G554D | Q9H4D0 | protein_coding | tolerated(0.16) | benign(0.018) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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