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Gene: BAZ2A |
Gene summary for BAZ2A |
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Gene information | Species | Human | Gene symbol | BAZ2A | Gene ID | 11176 |
Gene name | bromodomain adjacent to zinc finger domain 2A | |
Gene Alias | TIP5 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000183 | UniProtAcc | F8VU39 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11176 | BAZ2A | LZE4T | Human | Esophagus | ESCC | 3.25e-07 | 3.07e-01 | 0.0811 |
11176 | BAZ2A | LZE7T | Human | Esophagus | ESCC | 1.63e-06 | 5.95e-01 | 0.0667 |
11176 | BAZ2A | LZE8T | Human | Esophagus | ESCC | 6.72e-09 | 1.85e-01 | 0.067 |
11176 | BAZ2A | LZE22T | Human | Esophagus | ESCC | 9.28e-03 | 1.98e-01 | 0.068 |
11176 | BAZ2A | LZE24T | Human | Esophagus | ESCC | 1.87e-20 | 5.41e-01 | 0.0596 |
11176 | BAZ2A | LZE21T | Human | Esophagus | ESCC | 2.03e-05 | 3.75e-01 | 0.0655 |
11176 | BAZ2A | LZE6T | Human | Esophagus | ESCC | 3.52e-02 | 1.20e-01 | 0.0845 |
11176 | BAZ2A | P1T-E | Human | Esophagus | ESCC | 7.89e-16 | 8.31e-01 | 0.0875 |
11176 | BAZ2A | P2T-E | Human | Esophagus | ESCC | 8.55e-43 | 8.06e-01 | 0.1177 |
11176 | BAZ2A | P4T-E | Human | Esophagus | ESCC | 4.38e-16 | 3.27e-01 | 0.1323 |
11176 | BAZ2A | P5T-E | Human | Esophagus | ESCC | 1.39e-09 | 2.28e-01 | 0.1327 |
11176 | BAZ2A | P8T-E | Human | Esophagus | ESCC | 1.91e-35 | 7.01e-01 | 0.0889 |
11176 | BAZ2A | P9T-E | Human | Esophagus | ESCC | 1.16e-05 | 1.23e-01 | 0.1131 |
11176 | BAZ2A | P10T-E | Human | Esophagus | ESCC | 1.24e-25 | 4.04e-01 | 0.116 |
11176 | BAZ2A | P11T-E | Human | Esophagus | ESCC | 9.87e-07 | 3.35e-01 | 0.1426 |
11176 | BAZ2A | P12T-E | Human | Esophagus | ESCC | 6.33e-24 | 5.25e-01 | 0.1122 |
11176 | BAZ2A | P15T-E | Human | Esophagus | ESCC | 1.49e-16 | 5.15e-01 | 0.1149 |
11176 | BAZ2A | P16T-E | Human | Esophagus | ESCC | 1.01e-23 | 3.45e-01 | 0.1153 |
11176 | BAZ2A | P17T-E | Human | Esophagus | ESCC | 1.37e-14 | 5.79e-01 | 0.1278 |
11176 | BAZ2A | P19T-E | Human | Esophagus | ESCC | 3.05e-06 | 4.07e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00708973 | Esophagus | ESCC | transcription preinitiation complex assembly | 30/8552 | 36/18723 | 3.60e-06 | 3.95e-05 | 30 |
GO:00708281 | Esophagus | ESCC | heterochromatin organization | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:00063611 | Esophagus | ESCC | transcription initiation from RNA polymerase I promoter | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
GO:0045814 | Esophagus | ESCC | negative regulation of gene expression, epigenetic | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:00165703 | Liver | NAFLD | histone modification | 90/1882 | 463/18723 | 5.74e-10 | 1.28e-07 | 90 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:0043414 | Liver | NAFLD | macromolecule methylation | 47/1882 | 316/18723 | 4.08e-03 | 3.41e-02 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAZ2A | SNV | Missense_Mutation | c.4544N>C | p.Leu1515Pro | p.L1515P | Q9UIF9 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
BAZ2A | SNV | Missense_Mutation | c.1436C>A | p.Ala479Glu | p.A479E | Q9UIF9 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-CG-5722-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BAZ2A | SNV | Missense_Mutation | novel | c.4817T>C | p.Leu1606Pro | p.L1606P | Q9UIF9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
BAZ2A | SNV | Missense_Mutation | novel | c.5362N>T | p.Arg1788Trp | p.R1788W | Q9UIF9 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
BAZ2A | deletion | Frame_Shift_Del | novel | c.560delN | p.Phe187SerfsTer23 | p.F187Sfs*23 | Q9UIF9 | protein_coding | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BAZ2A | insertion | In_Frame_Ins | novel | c.2186_2188dupCTA | p.Thr729dup | p.T729dup | Q9UIF9 | protein_coding | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
BAZ2A | insertion | Frame_Shift_Ins | novel | c.216_217insTG | p.Ala73TrpfsTer107 | p.A73Wfs*107 | Q9UIF9 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11176 | BAZ2A | ENZYME | inhibitor | 252166772 | ||
11176 | BAZ2A | ENZYME | inhibitor | 249565913 |
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