![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ADGRL3 |
Gene summary for ADGRL3 |
![]() |
Gene information | Species | Human | Gene symbol | ADGRL3 | Gene ID | 23284 |
Gene name | adhesion G protein-coupled receptor L3 | |
Gene Alias | CIRL3 | |
Cytomap | 4q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001764 | UniProtAcc | Q9HAR2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23284 | ADGRL3 | EEC-subject3 | Human | Endometrium | EEC | 1.29e-03 | 3.08e-01 | -0.2525 |
23284 | ADGRL3 | P1_S1_AK | Human | Skin | AK | 3.09e-68 | 1.29e+00 | -0.3399 |
23284 | ADGRL3 | P2_S3_AK | Human | Skin | AK | 1.25e-59 | 1.11e+00 | -0.3287 |
23284 | ADGRL3 | P2_S4_SCCIS | Human | Skin | SCCIS | 2.99e-23 | 5.89e-01 | -0.3043 |
23284 | ADGRL3 | P3_S6_AK | Human | Skin | AK | 2.69e-62 | 1.19e+00 | -0.3256 |
23284 | ADGRL3 | P4_S8_cSCC | Human | Skin | cSCC | 5.69e-17 | 5.12e-01 | -0.3095 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432914 | Endometrium | EEC | cell junction assembly | 79/2168 | 420/18723 | 8.37e-06 | 1.85e-04 | 79 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:005080812 | Endometrium | EEC | synapse organization | 68/2168 | 426/18723 | 3.73e-03 | 2.49e-02 | 68 |
GO:003432919 | Skin | AK | cell junction assembly | 86/1910 | 420/18723 | 1.95e-10 | 2.68e-08 | 86 |
GO:00508088 | Skin | AK | synapse organization | 71/1910 | 426/18723 | 2.21e-05 | 4.07e-04 | 71 |
GO:00017644 | Skin | AK | neuron migration | 26/1910 | 156/18723 | 8.26e-03 | 4.13e-02 | 26 |
GO:0034329110 | Skin | SCCIS | cell junction assembly | 52/919 | 420/18723 | 7.89e-10 | 5.23e-07 | 52 |
GO:005080814 | Skin | SCCIS | synapse organization | 42/919 | 426/18723 | 1.43e-05 | 4.70e-04 | 42 |
GO:00987421 | Skin | SCCIS | cell-cell adhesion via plasma-membrane adhesion molecules | 26/919 | 273/18723 | 9.83e-04 | 1.23e-02 | 26 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRL3 | SNV | Missense_Mutation | rs370040630 | c.2798N>A | p.Arg933Gln | p.R933Q | Q9HAR2 | protein_coding | tolerated(0.47) | possibly_damaging(0.878) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ADGRL3 | SNV | Missense_Mutation | c.3338N>A | p.Ser1113Tyr | p.S1113Y | Q9HAR2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ADGRL3 | SNV | Missense_Mutation | rs758271339 | c.4019A>C | p.His1340Pro | p.H1340P | Q9HAR2 | protein_coding | tolerated(0.23) | benign(0) | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD |
ADGRL3 | SNV | Missense_Mutation | c.953G>A | p.Gly318Glu | p.G318E | Q9HAR2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADGRL3 | SNV | Missense_Mutation | c.2893C>A | p.Leu965Ile | p.L965I | Q9HAR2 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADGRL3 | SNV | Missense_Mutation | novel | c.1799N>T | p.Gly600Val | p.G600V | Q9HAR2 | protein_coding | deleterious(0.04) | benign(0.044) | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ADGRL3 | SNV | Missense_Mutation | novel | c.2265A>T | p.Leu755Phe | p.L755F | Q9HAR2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ADGRL3 | SNV | Missense_Mutation | c.2742G>T | p.Lys914Asn | p.K914N | Q9HAR2 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ADGRL3 | SNV | Missense_Mutation | novel | c.1480N>A | p.Leu494Ile | p.L494I | Q9HAR2 | protein_coding | tolerated(0.41) | benign(0.01) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ADGRL3 | SNV | Missense_Mutation | novel | c.1567N>A | p.Ala523Thr | p.A523T | Q9HAR2 | protein_coding | tolerated(0.17) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23284 | ADGRL3 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | nicotine | NICOTINE | ||
23284 | ADGRL3 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | methylphenidate | METHYLPHENIDATE | 25229170,29230023,22851411,25989180,20157310,22486528 |
Page: 1 |