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Gene: ADAMTS14 |
Gene summary for ADAMTS14 |
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Gene information | Species | Human | Gene symbol | ADAMTS14 | Gene ID | 140766 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |
Gene Alias | ADAMTS14 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8WXS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140766 | ADAMTS14 | ATC11 | Human | Thyroid | ATC | 2.49e-06 | 4.38e-01 | 0.3386 |
140766 | ADAMTS14 | ATC12 | Human | Thyroid | ATC | 1.28e-08 | 2.78e-01 | 0.34 |
140766 | ADAMTS14 | ATC13 | Human | Thyroid | ATC | 5.13e-22 | 4.36e-01 | 0.34 |
140766 | ADAMTS14 | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 6.90e-01 | 0.34 |
140766 | ADAMTS14 | ATC3 | Human | Thyroid | ATC | 1.86e-15 | 7.30e-01 | 0.338 |
140766 | ADAMTS14 | ATC4 | Human | Thyroid | ATC | 2.71e-11 | 3.34e-01 | 0.34 |
140766 | ADAMTS14 | ATC5 | Human | Thyroid | ATC | 1.14e-29 | 4.70e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:003019911 | Thyroid | ATC | collagen fibril organization | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS14 | SNV | Missense_Mutation | novel | c.976N>T | p.Gly326Trp | p.G326W | Q8WXS8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7391-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTS14 | SNV | Missense_Mutation | c.701C>G | p.Pro234Arg | p.P234R | Q8WXS8 | protein_coding | deleterious(0.04) | possibly_damaging(0.568) | TCGA-CV-5432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ADAMTS14 | SNV | Missense_Mutation | rs370358418 | c.1877N>T | p.Ser626Phe | p.S626F | Q8WXS8 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ADAMTS14 | SNV | Missense_Mutation | novel | c.1138N>T | p.His380Tyr | p.H380Y | Q8WXS8 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ADAMTS14 | SNV | Missense_Mutation | novel | c.3197N>T | p.Cys1066Phe | p.C1066F | Q8WXS8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QK-A8Z8-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | PD |
ADAMTS14 | SNV | Missense_Mutation | novel | c.1000N>A | p.Gln334Lys | p.Q334K | Q8WXS8 | protein_coding | deleterious(0.03) | possibly_damaging(0.602) | TCGA-UF-A7JJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
ADAMTS14 | SNV | Missense_Mutation | rs757459157 | c.1871N>A | p.Arg624His | p.R624H | Q8WXS8 | protein_coding | tolerated(0.13) | benign(0.259) | TCGA-EJ-5501-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
ADAMTS14 | SNV | Missense_Mutation | novel | c.2551A>T | p.Thr851Ser | p.T851S | Q8WXS8 | protein_coding | tolerated(0.53) | benign(0.009) | TCGA-KK-A8IF-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD |
ADAMTS14 | SNV | Missense_Mutation | c.1025N>G | p.Gln342Arg | p.Q342R | Q8WXS8 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ADAMTS14 | SNV | Missense_Mutation | c.1531N>G | p.Ser511Gly | p.S511G | Q8WXS8 | protein_coding | deleterious(0) | benign(0.222) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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