Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ABI3BP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ABI3BP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ABI3BP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ABI3BP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABI3BP | insertion | Nonsense_Mutation | novel | c.514_515insTTAAAAATTAGGTAACT | p.Lys172IlefsTer4 | p.K172Ifs*4 | Q7Z7G0 | protein_coding | | | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABI3BP | insertion | Frame_Shift_Ins | novel | c.1625_1626insCT | p.Lys543LeufsTer64 | p.K543Lfs*64 | Q7Z7G0 | protein_coding | | | TCGA-22-4591-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemzar | PD |
ABI3BP | deletion | Frame_Shift_Del | novel | c.569delA | p.Asn190ThrfsTer2 | p.N190Tfs*2 | Q7Z7G0 | protein_coding | | | TCGA-66-2786-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABI3BP | SNV | Missense_Mutation | | c.1897N>T | p.Asp633Tyr | p.D633Y | Q7Z7G0 | protein_coding | tolerated(0.24) | benign(0.157) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABI3BP | SNV | Missense_Mutation | novel | c.316N>T | p.Ala106Ser | p.A106S | Q7Z7G0 | protein_coding | deleterious(0.01) | possibly_damaging(0.516) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABI3BP | SNV | Missense_Mutation | novel | c.2357N>A | p.Pro786Gln | p.P786Q | Q7Z7G0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7091-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ABI3BP | SNV | Missense_Mutation | | c.1198G>A | p.Glu400Lys | p.E400K | Q7Z7G0 | protein_coding | tolerated(0.16) | benign(0.073) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ABI3BP | SNV | Missense_Mutation | novel | c.1271N>A | p.Arg424Lys | p.R424K | Q7Z7G0 | protein_coding | tolerated(0.16) | possibly_damaging(0.452) | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
ABI3BP | SNV | Missense_Mutation | rs372669157 | c.1520N>T | p.Pro507Leu | p.P507L | Q7Z7G0 | protein_coding | tolerated(0.59) | benign(0) | TCGA-P3-A6T7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
ABI3BP | SNV | Missense_Mutation | rs377450718 | c.1237N>T | p.Arg413Cys | p.R413C | Q7Z7G0 | protein_coding | deleterious(0.04) | benign(0.183) | TCGA-UF-A71E-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |