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Gene: ABCA3 |
Gene summary for ABCA3 |
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Gene information | Species | Human | Gene symbol | ABCA3 | Gene ID | 21 |
Gene name | ATP binding cassette subfamily A member 3 | |
Gene Alias | ABC-C | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q4LE27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
21 | ABCA3 | HCC2 | Human | Liver | HCC | 6.01e-05 | 2.88e+00 | 0.5341 |
21 | ABCA3 | S014 | Human | Liver | HCC | 5.03e-13 | 4.34e-01 | 0.2254 |
21 | ABCA3 | S015 | Human | Liver | HCC | 4.36e-06 | 2.86e-01 | 0.2375 |
21 | ABCA3 | S016 | Human | Liver | HCC | 5.69e-13 | 3.98e-01 | 0.2243 |
21 | ABCA3 | S027 | Human | Liver | HCC | 3.48e-08 | 5.20e-01 | 0.2446 |
21 | ABCA3 | S028 | Human | Liver | HCC | 2.19e-15 | 5.11e-01 | 0.2503 |
21 | ABCA3 | S029 | Human | Liver | HCC | 9.53e-10 | 2.85e-01 | 0.2581 |
21 | ABCA3 | TD9 | Human | Lung | IAC | 3.53e-05 | -1.37e-01 | 0.088 |
21 | ABCA3 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 1.33e-03 | 2.85e-02 | -0.1271 |
21 | ABCA3 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.18e-08 | 3.08e-02 | -0.1406 |
21 | ABCA3 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.09e-03 | -1.37e-01 | -0.1408 |
21 | ABCA3 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 9.91e-08 | 2.80e-01 | -0.138 |
21 | ABCA3 | RNA-P17T-P17T-6 | Human | Lung | IAC | 8.59e-04 | -6.42e-01 | 0.3385 |
21 | ABCA3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.01e-11 | 1.33e-01 | -0.2116 |
21 | ABCA3 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.91e-06 | 1.40e-02 | -0.1941 |
21 | ABCA3 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.34e-03 | -2.12e-02 | -0.2107 |
21 | ABCA3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.93e-11 | 1.28e-01 | -0.2119 |
21 | ABCA3 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.49e-02 | -8.37e-01 | 0.1829 |
21 | ABCA3 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.32e-03 | -7.56e-01 | 0.1859 |
21 | ABCA3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.08e-11 | -1.77e-01 | -0.0166 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:004854522 | Liver | HCC | response to steroid hormone | 206/7958 | 339/18723 | 6.81e-12 | 2.92e-10 | 206 |
GO:003133412 | Liver | HCC | positive regulation of protein-containing complex assembly | 150/7958 | 237/18723 | 7.35e-11 | 2.63e-09 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:00550882 | Liver | HCC | lipid homeostasis | 103/7958 | 167/18723 | 4.27e-07 | 7.18e-06 | 103 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
GO:00192162 | Liver | HCC | regulation of lipid metabolic process | 181/7958 | 331/18723 | 4.58e-06 | 5.79e-05 | 181 |
GO:005138421 | Liver | HCC | response to glucocorticoid | 90/7958 | 148/18723 | 5.18e-06 | 6.47e-05 | 90 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:003196021 | Liver | HCC | response to corticosteroid | 98/7958 | 167/18723 | 1.73e-05 | 1.87e-04 | 98 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:01200092 | Liver | HCC | intermembrane lipid transfer | 33/7958 | 48/18723 | 2.12e-04 | 1.63e-03 | 33 |
GO:00468902 | Liver | HCC | regulation of lipid biosynthetic process | 96/7958 | 171/18723 | 2.14e-04 | 1.63e-03 | 96 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
GO:00303012 | Liver | HCC | cholesterol transport | 65/7958 | 117/18723 | 2.95e-03 | 1.38e-02 | 65 |
GO:00159182 | Liver | HCC | sterol transport | 71/7958 | 130/18723 | 3.49e-03 | 1.58e-02 | 71 |
GO:003032311 | Liver | HCC | respiratory tube development | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:003032411 | Liver | HCC | lung development | 91/7958 | 177/18723 | 1.01e-02 | 3.80e-02 | 91 |
GO:0048875 | Lung | IAC | chemical homeostasis within a tissue | 11/2061 | 14/18723 | 7.44e-09 | 1.05e-06 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCA3 | SNV | Missense_Mutation | c.2993N>A | p.Arg998His | p.R998H | Q99758 | protein_coding | tolerated(0.44) | benign(0.022) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD | |
ABCA3 | SNV | Missense_Mutation | rs145251229 | c.4085C>T | p.Ala1362Val | p.A1362V | Q99758 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-KK-A8IA-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | lupron | SD |
ABCA3 | SNV | Missense_Mutation | novel | c.3250N>A | p.Leu1084Met | p.L1084M | Q99758 | protein_coding | tolerated(0.29) | benign(0.015) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ABCA3 | SNV | Missense_Mutation | rs187784898 | c.2141G>A | p.Arg714His | p.R714H | Q99758 | protein_coding | deleterious(0.05) | possibly_damaging(0.812) | TCGA-BR-4357-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ABCA3 | SNV | Missense_Mutation | rs762699052 | c.3902C>T | p.Pro1301Leu | p.P1301L | Q99758 | protein_coding | tolerated(0.53) | benign(0.036) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCA3 | SNV | Missense_Mutation | rs769313907 | c.74C>T | p.Thr25Met | p.T25M | Q99758 | protein_coding | deleterious(0.04) | probably_damaging(0.966) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABCA3 | SNV | Missense_Mutation | c.826C>T | p.Leu276Phe | p.L276F | Q99758 | protein_coding | tolerated(0.09) | possibly_damaging(0.78) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ABCA3 | SNV | Missense_Mutation | rs776453529 | c.4261G>A | p.Gly1421Arg | p.G1421R | Q99758 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-A4IZ-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ABCA3 | SNV | Missense_Mutation | rs781422468 | c.4648C>T | p.Arg1550Trp | p.R1550W | Q99758 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
ABCA3 | SNV | Missense_Mutation | rs374908506 | c.1672N>A | p.Glu558Lys | p.E558K | Q99758 | protein_coding | tolerated(0.1) | benign(0.234) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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