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Gene: USP40 |
Gene summary for USP40 |
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Gene information | Species | Human | Gene symbol | USP40 | Gene ID | 55230 |
Gene name | ubiquitin specific peptidase 40 | |
Gene Alias | USP40 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9NVE5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55230 | USP40 | LZE4T | Human | Esophagus | ESCC | 2.56e-05 | 1.67e-01 | 0.0811 |
55230 | USP40 | LZE24T | Human | Esophagus | ESCC | 5.10e-12 | 2.66e-01 | 0.0596 |
55230 | USP40 | LZE21T | Human | Esophagus | ESCC | 1.27e-03 | 2.99e-01 | 0.0655 |
55230 | USP40 | P2T-E | Human | Esophagus | ESCC | 5.86e-09 | 1.80e-01 | 0.1177 |
55230 | USP40 | P4T-E | Human | Esophagus | ESCC | 1.16e-10 | 2.58e-01 | 0.1323 |
55230 | USP40 | P5T-E | Human | Esophagus | ESCC | 4.61e-06 | 1.23e-01 | 0.1327 |
55230 | USP40 | P8T-E | Human | Esophagus | ESCC | 5.56e-17 | 2.72e-01 | 0.0889 |
55230 | USP40 | P9T-E | Human | Esophagus | ESCC | 1.13e-05 | 1.50e-01 | 0.1131 |
55230 | USP40 | P10T-E | Human | Esophagus | ESCC | 9.67e-18 | 2.69e-01 | 0.116 |
55230 | USP40 | P12T-E | Human | Esophagus | ESCC | 5.15e-15 | 2.92e-01 | 0.1122 |
55230 | USP40 | P15T-E | Human | Esophagus | ESCC | 1.46e-17 | 4.12e-01 | 0.1149 |
55230 | USP40 | P16T-E | Human | Esophagus | ESCC | 2.24e-14 | 2.78e-01 | 0.1153 |
55230 | USP40 | P20T-E | Human | Esophagus | ESCC | 8.14e-06 | 1.75e-01 | 0.1124 |
55230 | USP40 | P21T-E | Human | Esophagus | ESCC | 2.56e-09 | 1.88e-01 | 0.1617 |
55230 | USP40 | P22T-E | Human | Esophagus | ESCC | 1.13e-09 | 1.72e-01 | 0.1236 |
55230 | USP40 | P23T-E | Human | Esophagus | ESCC | 6.25e-05 | 1.03e-01 | 0.108 |
55230 | USP40 | P24T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.06e-01 | 0.1287 |
55230 | USP40 | P26T-E | Human | Esophagus | ESCC | 2.80e-08 | 1.30e-01 | 0.1276 |
55230 | USP40 | P27T-E | Human | Esophagus | ESCC | 1.38e-11 | 1.79e-01 | 0.1055 |
55230 | USP40 | P28T-E | Human | Esophagus | ESCC | 1.66e-12 | 2.82e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00316477 | Liver | NAFLD | regulation of protein stability | 61/1882 | 298/18723 | 5.00e-08 | 4.71e-06 | 61 |
GO:0070646 | Liver | NAFLD | protein modification by small protein removal | 29/1882 | 157/18723 | 9.11e-04 | 1.09e-02 | 29 |
GO:0016579 | Liver | NAFLD | protein deubiquitination | 26/1882 | 139/18723 | 1.35e-03 | 1.52e-02 | 26 |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
GO:00316478 | Lung | IAC | regulation of protein stability | 62/2061 | 298/18723 | 5.37e-07 | 3.32e-05 | 62 |
GO:003164713 | Lung | AIS | regulation of protein stability | 62/1849 | 298/18723 | 1.06e-08 | 1.63e-06 | 62 |
GO:0031647113 | Thyroid | PTC | regulation of protein stability | 174/5968 | 298/18723 | 2.05e-21 | 4.05e-19 | 174 |
GO:00706465 | Thyroid | PTC | protein modification by small protein removal | 71/5968 | 157/18723 | 3.03e-04 | 2.12e-03 | 71 |
GO:00165794 | Thyroid | PTC | protein deubiquitination | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:003164734 | Thyroid | ATC | regulation of protein stability | 177/6293 | 298/18723 | 4.08e-20 | 6.46e-18 | 177 |
GO:007064613 | Thyroid | ATC | protein modification by small protein removal | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP40 | deletion | Frame_Shift_Del | rs766340074 | c.3477delA | p.Lys1159AsnfsTer12 | p.K1159Nfs*12 | Q9NVE5 | protein_coding | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
USP40 | deletion | Frame_Shift_Del | rs766340074 | c.3477delA | p.Lys1159AsnfsTer12 | p.K1159Nfs*12 | Q9NVE5 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | ||
USP40 | deletion | Frame_Shift_Del | rs766340074 | c.3477delA | p.Lys1159AsnfsTer12 | p.K1159Nfs*12 | Q9NVE5 | protein_coding | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
USP40 | deletion | Frame_Shift_Del | rs766340074 | c.3477delN | p.Lys1159AsnfsTer12 | p.K1159Nfs*12 | Q9NVE5 | protein_coding | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
USP40 | deletion | Frame_Shift_Del | rs766340074 | c.3477delN | p.Lys1159AsnfsTer12 | p.K1159Nfs*12 | Q9NVE5 | protein_coding | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
USP40 | SNV | Missense_Mutation | rs368386083 | c.3611G>A | p.Arg1204Gln | p.R1204Q | Q9NVE5 | protein_coding | tolerated(0.65) | benign(0) | TCGA-BJ-A0Z3-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP40 | insertion | Frame_Shift_Ins | novel | c.777_778insT | p.Arg260Ter | p.R260* | Q9NVE5 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
USP40 | insertion | Frame_Shift_Ins | novel | c.776_777insCACAATAAACCAACTGAAAATCGGGTCAATA | p.Arg260ThrfsTer13 | p.R260Tfs*13 | Q9NVE5 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
USP40 | insertion | In_Frame_Ins | novel | c.584_585insTCCTCG | p.Glu195delinsAspProArg | p.E195delinsDPR | Q9NVE5 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
USP40 | insertion | Frame_Shift_Ins | novel | c.1258_1259insAGGGG | p.Arg420GlnfsTer5 | p.R420Qfs*5 | Q9NVE5 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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