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Gene: TRPM2 |
Gene summary for TRPM2 |
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Gene information | Species | Human | Gene symbol | TRPM2 | Gene ID | 7226 |
Gene name | transient receptor potential cation channel subfamily M member 2 | |
Gene Alias | EREG1 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DVI8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7226 | TRPM2 | P4T-E | Human | Esophagus | ESCC | 4.90e-05 | 1.77e-01 | 0.1323 |
7226 | TRPM2 | P5T-E | Human | Esophagus | ESCC | 1.47e-14 | 3.00e-01 | 0.1327 |
7226 | TRPM2 | P9T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.35e-01 | 0.1131 |
7226 | TRPM2 | P10T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.47e-01 | 0.116 |
7226 | TRPM2 | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.78e-01 | 0.1426 |
7226 | TRPM2 | P16T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.76e-02 | 0.1153 |
7226 | TRPM2 | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 1.90e-01 | 0.1278 |
7226 | TRPM2 | P21T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.76e-01 | 0.1617 |
7226 | TRPM2 | P24T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.33e-01 | 0.1287 |
7226 | TRPM2 | P26T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.19e-01 | 0.1276 |
7226 | TRPM2 | P27T-E | Human | Esophagus | ESCC | 3.75e-03 | 8.70e-02 | 0.1055 |
7226 | TRPM2 | P28T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.64e-01 | 0.1149 |
7226 | TRPM2 | P31T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.73e-02 | 0.1251 |
7226 | TRPM2 | P32T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.73e-01 | 0.1666 |
7226 | TRPM2 | P37T-E | Human | Esophagus | ESCC | 4.28e-02 | 9.24e-02 | 0.1371 |
7226 | TRPM2 | P39T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.09e-01 | 0.0894 |
7226 | TRPM2 | P49T-E | Human | Esophagus | ESCC | 2.95e-08 | 5.18e-01 | 0.1768 |
7226 | TRPM2 | P62T-E | Human | Esophagus | ESCC | 5.02e-08 | 1.95e-01 | 0.1302 |
7226 | TRPM2 | P74T-E | Human | Esophagus | ESCC | 1.21e-21 | 5.70e-01 | 0.1479 |
7226 | TRPM2 | P76T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.10e-01 | 0.1207 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:0009408110 | Esophagus | ESCC | response to heat | 77/8552 | 110/18723 | 2.01e-07 | 3.11e-06 | 77 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:00703018 | Esophagus | ESCC | cellular response to hydrogen peroxide | 68/8552 | 98/18723 | 1.70e-06 | 2.03e-05 | 68 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:003153218 | Esophagus | ESCC | actin cytoskeleton reorganization | 72/8552 | 107/18723 | 5.03e-06 | 5.31e-05 | 72 |
GO:1901216111 | Esophagus | ESCC | positive regulation of neuron death | 65/8552 | 97/18723 | 1.76e-05 | 1.56e-04 | 65 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:000926619 | Esophagus | ESCC | response to temperature stimulus | 106/8552 | 178/18723 | 1.30e-04 | 8.84e-04 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462121 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa0462131 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa046214 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
hsa049219 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
hsa046215 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
hsa0492112 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRPM2 | insertion | Nonsense_Mutation | novel | c.950_951insTGTGTTCTG | p.Gly317_Gly318insValPheTer | p.G317_G318insVF* | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TRPM2 | insertion | Frame_Shift_Ins | novel | c.422dupA | p.Tyr142ValfsTer127 | p.Y142Vfs*127 | protein_coding | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |||
TRPM2 | SNV | Missense_Mutation | c.2258N>A | p.Leu753Gln | p.L753Q | protein_coding | deleterious(0.03) | possibly_damaging(0.653) | TCGA-CC-A7II-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
TRPM2 | SNV | Missense_Mutation | c.1359N>G | p.Asp453Glu | p.D453E | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-DD-A4NA-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TRPM2 | SNV | Missense_Mutation | c.2989N>T | p.Ser997Cys | p.S997C | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-G3-A3CI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TRPM2 | SNV | Missense_Mutation | novel | c.2185T>C | p.Phe729Leu | p.F729L | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-WJ-A86L-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRPM2 | SNV | Missense_Mutation | novel | c.1817N>A | p.Ser606Tyr | p.S606Y | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-05-4390-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
TRPM2 | SNV | Missense_Mutation | rs774031744 | c.3265N>A | p.His1089Asn | p.H1089N | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TRPM2 | SNV | Missense_Mutation | novel | c.1276C>G | p.Gln426Glu | p.Q426E | protein_coding | deleterious(0.03) | benign(0.2) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TRPM2 | SNV | Missense_Mutation | c.3034N>T | p.Asp1012Tyr | p.D1012Y | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650269 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 135651442 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178102951 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 53801022 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650220 | ECONAZOLE | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 135652736 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135652738 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178101017 | ||
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650114 | CLOTRIMAZOLE | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 53801024 | MICONAZOLE |
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