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Gene: TLN2 |
Gene summary for TLN2 |
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Gene information | Species | Human | Gene symbol | TLN2 | Gene ID | 83660 |
Gene name | talin 2 | |
Gene Alias | ILWEQ | |
Cytomap | 15q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9Y4G6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83660 | TLN2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.60e-22 | -6.43e-01 | 0.0155 |
83660 | TLN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.13e-09 | 6.41e-01 | -0.1954 |
83660 | TLN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.19e-03 | -3.13e-01 | -0.1464 |
83660 | TLN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.34e-16 | -7.11e-01 | 0.096 |
83660 | TLN2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.06e-04 | -8.71e-01 | 0.0451 |
83660 | TLN2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.82e-07 | -6.66e-01 | 0.0528 |
83660 | TLN2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.27e-09 | -4.52e-01 | 0.0674 |
83660 | TLN2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.06e-04 | -4.27e-01 | 0.0112 |
83660 | TLN2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.63e-12 | -6.49e-01 | 0.0588 |
83660 | TLN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.01e-39 | -8.26e-01 | 0.294 |
83660 | TLN2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.50e-55 | -1.06e+00 | 0.3859 |
83660 | TLN2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.07e-17 | -1.02e+00 | 0.2585 |
83660 | TLN2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.28e-51 | -9.32e-01 | 0.3005 |
83660 | TLN2 | F007 | Human | Colorectum | FAP | 8.09e-05 | -3.94e-01 | 0.1176 |
83660 | TLN2 | A002-C-010 | Human | Colorectum | FAP | 3.77e-04 | -3.49e-01 | 0.242 |
83660 | TLN2 | A001-C-207 | Human | Colorectum | FAP | 1.18e-06 | -3.72e-01 | 0.1278 |
83660 | TLN2 | A015-C-203 | Human | Colorectum | FAP | 3.71e-38 | -6.70e-01 | -0.1294 |
83660 | TLN2 | A015-C-204 | Human | Colorectum | FAP | 7.06e-13 | -5.73e-01 | -0.0228 |
83660 | TLN2 | A014-C-040 | Human | Colorectum | FAP | 2.23e-11 | -7.55e-01 | -0.1184 |
83660 | TLN2 | A002-C-201 | Human | Colorectum | FAP | 1.54e-23 | -6.07e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0007043 | Colorectum | AD | cell-cell junction assembly | 57/3918 | 146/18723 | 4.18e-07 | 1.61e-05 | 57 |
GO:00452161 | Colorectum | SER | cell-cell junction organization | 63/2897 | 200/18723 | 9.15e-09 | 7.80e-07 | 63 |
GO:00070431 | Colorectum | SER | cell-cell junction assembly | 45/2897 | 146/18723 | 2.23e-06 | 9.31e-05 | 45 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00452162 | Colorectum | MSS | cell-cell junction organization | 69/3467 | 200/18723 | 5.07e-08 | 2.70e-06 | 69 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00070432 | Colorectum | MSS | cell-cell junction assembly | 50/3467 | 146/18723 | 4.24e-06 | 1.21e-04 | 50 |
GO:00343293 | Colorectum | FAP | cell junction assembly | 105/2622 | 420/18723 | 1.03e-09 | 2.18e-07 | 105 |
GO:00452164 | Colorectum | FAP | cell-cell junction organization | 58/2622 | 200/18723 | 2.51e-08 | 2.36e-06 | 58 |
GO:00070434 | Colorectum | FAP | cell-cell junction assembly | 39/2622 | 146/18723 | 3.74e-05 | 8.09e-04 | 39 |
GO:00343294 | Colorectum | CRC | cell junction assembly | 83/2078 | 420/18723 | 1.08e-07 | 1.29e-05 | 83 |
GO:00452165 | Colorectum | CRC | cell-cell junction organization | 48/2078 | 200/18723 | 1.67e-07 | 1.72e-05 | 48 |
GO:00070435 | Colorectum | CRC | cell-cell junction assembly | 31/2078 | 146/18723 | 2.75e-04 | 4.40e-03 | 31 |
GO:00343299 | Endometrium | AEH | cell junction assembly | 78/2100 | 420/18723 | 4.80e-06 | 1.24e-04 | 78 |
GO:004521610 | Endometrium | AEH | cell-cell junction organization | 42/2100 | 200/18723 | 4.26e-05 | 7.20e-04 | 42 |
GO:000704310 | Endometrium | AEH | cell-cell junction assembly | 30/2100 | 146/18723 | 7.29e-04 | 6.98e-03 | 30 |
GO:003432914 | Endometrium | EEC | cell junction assembly | 79/2168 | 420/18723 | 8.37e-06 | 1.85e-04 | 79 |
GO:004521615 | Endometrium | EEC | cell-cell junction organization | 42/2168 | 200/18723 | 8.84e-05 | 1.25e-03 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa051661 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa040154 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa051662 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa051315 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa051663 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa045102 | Colorectum | FAP | Focal adhesion | 61/1404 | 203/8465 | 1.03e-06 | 2.15e-05 | 1.31e-05 | 61 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLN2 | SNV | Missense_Mutation | novel | c.4517N>T | p.Ala1506Val | p.A1506V | Q9Y4G6 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLN2 | SNV | Missense_Mutation | novel | c.4213C>A | p.Leu1405Met | p.L1405M | Q9Y4G6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
TLN2 | SNV | Missense_Mutation | novel | c.7218C>A | p.Ser2406Arg | p.S2406R | Q9Y4G6 | protein_coding | tolerated(0.06) | possibly_damaging(0.593) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
TLN2 | SNV | Missense_Mutation | rs758650990 | c.3686C>T | p.Ser1229Leu | p.S1229L | Q9Y4G6 | protein_coding | tolerated(0.12) | benign(0.028) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TLN2 | SNV | Missense_Mutation | rs142261304 | c.5117C>T | p.Ser1706Leu | p.S1706L | Q9Y4G6 | protein_coding | tolerated(0.22) | benign(0.154) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TLN2 | SNV | Missense_Mutation | novel | c.6050N>T | p.Arg2017Met | p.R2017M | Q9Y4G6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLN2 | SNV | Missense_Mutation | novel | c.5416N>A | p.Glu1806Lys | p.E1806K | Q9Y4G6 | protein_coding | deleterious(0.01) | possibly_damaging(0.701) | TCGA-EY-A2OM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
TLN2 | SNV | Missense_Mutation | novel | c.4709N>T | p.Ala1570Val | p.A1570V | Q9Y4G6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLN2 | SNV | Missense_Mutation | novel | c.5032N>A | p.Glu1678Lys | p.E1678K | Q9Y4G6 | protein_coding | deleterious(0) | benign(0.205) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLN2 | SNV | Missense_Mutation | novel | c.126N>C | p.Gln42His | p.Q42H | Q9Y4G6 | protein_coding | tolerated(0.19) | possibly_damaging(0.781) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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