![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TLE4 |
Gene summary for TLE4 |
![]() |
Gene information | Species | Human | Gene symbol | TLE4 | Gene ID | 7091 |
Gene name | TLE family member 4, transcriptional corepressor | |
Gene Alias | BCE-1 | |
Cytomap | 9q21.31 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q04727 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7091 | TLE4 | N_HPV_2 | Human | Cervix | N_HPV | 2.09e-02 | 1.64e-01 | -0.0131 |
7091 | TLE4 | CCI_1 | Human | Cervix | CC | 4.57e-02 | 6.40e-01 | 0.528 |
7091 | TLE4 | CCI_2 | Human | Cervix | CC | 1.04e-02 | 1.14e+00 | 0.5249 |
7091 | TLE4 | CCI_3 | Human | Cervix | CC | 2.15e-14 | 1.01e+00 | 0.516 |
7091 | TLE4 | sample1 | Human | Cervix | CC | 1.50e-05 | 5.61e-01 | 0.0959 |
7091 | TLE4 | T1 | Human | Cervix | CC | 1.12e-21 | 7.36e-01 | 0.0918 |
7091 | TLE4 | LZE4T | Human | Esophagus | ESCC | 1.11e-07 | 4.34e-01 | 0.0811 |
7091 | TLE4 | LZE8T | Human | Esophagus | ESCC | 2.84e-02 | 6.77e-02 | 0.067 |
7091 | TLE4 | LZE20T | Human | Esophagus | ESCC | 3.68e-06 | 1.98e-01 | 0.0662 |
7091 | TLE4 | LZE24T | Human | Esophagus | ESCC | 1.22e-12 | 4.80e-01 | 0.0596 |
7091 | TLE4 | P1T-E | Human | Esophagus | ESCC | 7.64e-07 | 2.71e-01 | 0.0875 |
7091 | TLE4 | P2T-E | Human | Esophagus | ESCC | 4.21e-27 | 5.87e-01 | 0.1177 |
7091 | TLE4 | P4T-E | Human | Esophagus | ESCC | 2.19e-12 | 3.05e-01 | 0.1323 |
7091 | TLE4 | P5T-E | Human | Esophagus | ESCC | 1.24e-08 | 3.86e-01 | 0.1327 |
7091 | TLE4 | P8T-E | Human | Esophagus | ESCC | 7.89e-12 | 2.74e-01 | 0.0889 |
7091 | TLE4 | P9T-E | Human | Esophagus | ESCC | 7.58e-18 | 4.78e-01 | 0.1131 |
7091 | TLE4 | P10T-E | Human | Esophagus | ESCC | 1.14e-18 | 3.11e-01 | 0.116 |
7091 | TLE4 | P11T-E | Human | Esophagus | ESCC | 4.27e-08 | 4.18e-01 | 0.1426 |
7091 | TLE4 | P12T-E | Human | Esophagus | ESCC | 8.89e-21 | 3.91e-01 | 0.1122 |
7091 | TLE4 | P15T-E | Human | Esophagus | ESCC | 1.22e-17 | 6.35e-01 | 0.1149 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00301784 | Cervix | CC | negative regulation of Wnt signaling pathway | 35/2311 | 170/18723 | 1.52e-03 | 1.17e-02 | 35 |
GO:00900901 | Cervix | CC | negative regulation of canonical Wnt signaling pathway | 29/2311 | 137/18723 | 2.40e-03 | 1.70e-02 | 29 |
GO:19908234 | Cervix | CC | response to leukemia inhibitory factor | 22/2311 | 95/18723 | 2.40e-03 | 1.70e-02 | 22 |
GO:19908304 | Cervix | CC | cellular response to leukemia inhibitory factor | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
GO:199082312 | Cervix | N_HPV | response to leukemia inhibitory factor | 9/534 | 95/18723 | 1.56e-03 | 1.63e-02 | 9 |
GO:199083011 | Cervix | N_HPV | cellular response to leukemia inhibitory factor | 8/534 | 94/18723 | 5.41e-03 | 3.87e-02 | 8 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:199082316 | Esophagus | ESCC | response to leukemia inhibitory factor | 60/8552 | 95/18723 | 4.41e-04 | 2.48e-03 | 60 |
GO:199083015 | Esophagus | ESCC | cellular response to leukemia inhibitory factor | 59/8552 | 94/18723 | 6.19e-04 | 3.32e-03 | 59 |
GO:00301788 | Esophagus | ESCC | negative regulation of Wnt signaling pathway | 97/8552 | 170/18723 | 1.81e-03 | 8.31e-03 | 97 |
GO:00900905 | Esophagus | ESCC | negative regulation of canonical Wnt signaling pathway | 78/8552 | 137/18723 | 5.17e-03 | 1.95e-02 | 78 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa04330 | Cervix | CC | Notch signaling pathway | 17/1267 | 62/8465 | 7.99e-03 | 2.56e-02 | 1.51e-02 | 17 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa043301 | Cervix | CC | Notch signaling pathway | 17/1267 | 62/8465 | 7.99e-03 | 2.56e-02 | 1.51e-02 | 17 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa043108 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431011 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431021 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431031 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431041 | Lung | MIAC | Wnt signaling pathway | 21/507 | 171/8465 | 1.30e-03 | 1.40e-02 | 1.01e-02 | 21 |
hsa0431051 | Lung | MIAC | Wnt signaling pathway | 21/507 | 171/8465 | 1.30e-03 | 1.40e-02 | 1.01e-02 | 21 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0431016 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0431017 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0433021 | Oral cavity | NEOLP | Notch signaling pathway | 21/1112 | 62/8465 | 2.23e-05 | 1.87e-04 | 1.18e-04 | 21 |
hsa0431024 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
hsa0433031 | Oral cavity | NEOLP | Notch signaling pathway | 21/1112 | 62/8465 | 2.23e-05 | 1.87e-04 | 1.18e-04 | 21 |
hsa0431034 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLE4 | SNV | Missense_Mutation | c.2050C>T | p.Arg684Trp | p.R684W | Q04727 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TLE4 | SNV | Missense_Mutation | c.1181N>T | p.Thr394Ile | p.T394I | Q04727 | protein_coding | deleterious(0.05) | possibly_damaging(0.454) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
TLE4 | SNV | Missense_Mutation | c.521N>C | p.Ser174Thr | p.S174T | Q04727 | protein_coding | tolerated(0.22) | benign(0.082) | TCGA-CG-5720-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TLE4 | SNV | Missense_Mutation | rs140356709 | c.1732N>T | p.Arg578Cys | p.R578C | Q04727 | protein_coding | tolerated(0.09) | benign(0.099) | TCGA-D7-6817-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5 fluorouracilum+leucovorin | SD |
TLE4 | SNV | Missense_Mutation | c.1495N>A | p.Asp499Asn | p.D499N | Q04727 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
TLE4 | SNV | Missense_Mutation | novel | c.1798C>T | p.Arg600Cys | p.R600C | Q04727 | protein_coding | deleterious(0.04) | possibly_damaging(0.51) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
TLE4 | SNV | Missense_Mutation | c.193N>T | p.Arg65Trp | p.R65W | Q04727 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
TLE4 | SNV | Missense_Mutation | novel | c.2320N>G | p.Ser774Ala | p.S774A | Q04727 | protein_coding | deleterious(0) | possibly_damaging(0.668) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
TLE4 | SNV | Missense_Mutation | novel | c.1109N>G | p.Asn370Ser | p.N370S | Q04727 | protein_coding | tolerated(1) | benign(0.001) | TCGA-VQ-A8P3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
TLE4 | SNV | Missense_Mutation | c.74A>C | p.Lys25Thr | p.K25T | Q04727 | protein_coding | deleterious(0) | benign(0.407) | TCGA-VQ-A8PK-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |