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Gene: SBF2 |
Gene summary for SBF2 |
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Gene information | Species | Human | Gene symbol | SBF2 | Gene ID | 81846 |
Gene name | SET binding factor 2 | |
Gene Alias | CMT4B2 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q86WG5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81846 | SBF2 | CCI_1 | Human | Cervix | CC | 3.34e-07 | 7.85e-01 | 0.528 |
81846 | SBF2 | CCI_2 | Human | Cervix | CC | 2.86e-06 | 9.66e-01 | 0.5249 |
81846 | SBF2 | CCI_3 | Human | Cervix | CC | 8.80e-27 | 1.34e+00 | 0.516 |
81846 | SBF2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.15e-40 | -8.60e-01 | 0.0155 |
81846 | SBF2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.33e-09 | -6.60e-01 | -0.1808 |
81846 | SBF2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.68e-06 | -9.36e-01 | 0.0216 |
81846 | SBF2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.29e-12 | -7.96e-01 | -0.1207 |
81846 | SBF2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.39e-05 | -5.16e-01 | -0.1526 |
81846 | SBF2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.19e-22 | -6.00e-01 | -0.1464 |
81846 | SBF2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.83e-04 | -3.72e-01 | -0.1001 |
81846 | SBF2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.20e-04 | -6.45e-01 | -0.1706 |
81846 | SBF2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.83e-06 | -8.26e-01 | -0.2061 |
81846 | SBF2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.06e-07 | -9.11e-01 | -0.1462 |
81846 | SBF2 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.54e-05 | -6.08e-01 | -0.0842 |
81846 | SBF2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 6.28e-05 | -9.38e-01 | -0.00410000000000005 |
81846 | SBF2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.99e-04 | -6.56e-01 | -0.0179 |
81846 | SBF2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.13e-19 | -6.79e-01 | 0.096 |
81846 | SBF2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.52e-05 | -5.02e-01 | 0.0446 |
81846 | SBF2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.63e-03 | -9.09e-01 | 0.0451 |
81846 | SBF2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.92e-05 | -7.35e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430875 | Liver | NAFLD | regulation of GTPase activity | 62/1882 | 348/18723 | 5.65e-06 | 2.03e-04 | 62 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00430876 | Lung | IAC | regulation of GTPase activity | 67/2061 | 348/18723 | 3.43e-06 | 1.44e-04 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SBF2 | SNV | Missense_Mutation | novel | c.2780T>C | p.Phe927Ser | p.F927S | Q86WG5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SBF2 | SNV | Missense_Mutation | novel | c.2861A>T | p.Lys954Met | p.K954M | Q86WG5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SBF2 | SNV | Missense_Mutation | c.3553T>C | p.Trp1185Arg | p.W1185R | Q86WG5 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SBF2 | SNV | Missense_Mutation | novel | c.4099N>G | p.Thr1367Ala | p.T1367A | Q86WG5 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-44-6775-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SBF2 | SNV | Missense_Mutation | c.2014N>T | p.Thr672Ser | p.T672S | Q86WG5 | protein_coding | tolerated(0.69) | benign(0.05) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SBF2 | SNV | Missense_Mutation | c.3616N>T | p.Val1206Phe | p.V1206F | Q86WG5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
SBF2 | SNV | Missense_Mutation | c.1588G>T | p.Gly530Cys | p.G530C | Q86WG5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8092-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SBF2 | SNV | Missense_Mutation | c.5507N>G | p.Gln1836Arg | p.Q1836R | Q86WG5 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SBF2 | SNV | Missense_Mutation | c.921C>A | p.His307Gln | p.H307Q | Q86WG5 | protein_coding | tolerated(0.08) | benign(0.141) | TCGA-62-A46U-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SBF2 | SNV | Missense_Mutation | c.3721G>T | p.Ala1241Ser | p.A1241S | Q86WG5 | protein_coding | tolerated(1) | benign(0.003) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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