Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430876 | Lung | IAC | regulation of GTPase activity | 67/2061 | 348/18723 | 3.43e-06 | 1.44e-04 | 67 |
GO:004308711 | Lung | AIS | regulation of GTPase activity | 65/1849 | 348/18723 | 3.35e-07 | 2.83e-05 | 65 |
GO:004308721 | Lung | MIAC | regulation of GTPase activity | 41/967 | 348/18723 | 7.39e-07 | 1.08e-04 | 41 |
GO:00430879 | Prostate | BPH | regulation of GTPase activity | 88/3107 | 348/18723 | 2.04e-05 | 2.49e-04 | 88 |
GO:004308713 | Prostate | Tumor | regulation of GTPase activity | 88/3246 | 348/18723 | 1.04e-04 | 1.00e-03 | 88 |
GO:004308716 | Skin | AK | regulation of GTPase activity | 54/1910 | 348/18723 | 1.17e-03 | 8.98e-03 | 54 |
GO:004308717 | Skin | SCCIS | regulation of GTPase activity | 39/919 | 348/18723 | 1.38e-06 | 8.71e-05 | 39 |
GO:004308718 | Thyroid | PTC | regulation of GTPase activity | 148/5968 | 348/18723 | 1.63e-05 | 1.71e-04 | 148 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASAL2 | SNV | Missense_Mutation | novel | c.337N>T | p.Val113Leu | p.V113L | Q9UJF2 | protein_coding | tolerated(0.77) | benign(0) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RASAL2 | SNV | Missense_Mutation | | c.3256N>G | p.Gln1086Glu | p.Q1086E | Q9UJF2 | protein_coding | tolerated(0.96) | benign(0.036) | TCGA-39-5024-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
RASAL2 | SNV | Missense_Mutation | novel | c.3035N>A | p.Arg1012Gln | p.R1012Q | Q9UJF2 | protein_coding | tolerated(0.13) | benign(0.08) | TCGA-46-6026-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
RASAL2 | SNV | Missense_Mutation | rs768397267 | c.3748N>T | p.Arg1250Trp | p.R1250W | Q9UJF2 | protein_coding | deleterious(0) | benign(0.27) | TCGA-56-1622-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RASAL2 | SNV | Missense_Mutation | | c.2467N>G | p.Gln823Glu | p.Q823E | Q9UJF2 | protein_coding | tolerated(0.11) | possibly_damaging(0.554) | TCGA-56-5897-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RASAL2 | SNV | Missense_Mutation | novel | c.2066G>T | p.Trp689Leu | p.W689L | Q9UJF2 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-56-7223-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
RASAL2 | SNV | Missense_Mutation | novel | c.3817N>A | p.Gly1273Ser | p.G1273S | Q9UJF2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RASAL2 | SNV | Missense_Mutation | novel | c.1160N>G | p.Lys387Arg | p.K387R | Q9UJF2 | protein_coding | tolerated(0.57) | benign(0.018) | TCGA-63-A5MI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | vinorelbine | SD |
RASAL2 | SNV | Missense_Mutation | rs761936330 | c.2243G>A | p.Arg748His | p.R748H | Q9UJF2 | protein_coding | deleterious(0.01) | benign(0.368) | TCGA-66-2792-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
RASAL2 | SNV | Missense_Mutation | novel | c.3282G>A | p.Met1094Ile | p.M1094I | Q9UJF2 | protein_coding | deleterious(0.03) | benign(0.39) | TCGA-85-A4QR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |